Suchergebnisse

As soon as the works of Gustave Flaubert were translated into Chinese, Chinese readers immediately paid great attention to them. His philosophical thoughts, objectivity and accuracy in writing caused a resonance in Chinese literary circles of the time and profoundly influenced their writings. Chinese translator and novelist, Li Jieren, who was the first translator of Madame Bovary, admitted he was much inspired by the style of Flaubert in this novel. In 1935, ten years after the first translation of Madame Bovary, he began writing his masterpiece Ripples across stagnant water which has been considered by Chinese critics as the Chinese Madame Bovary. Astonishing similarities can be noticed between the two main characters from various aspects. Despite these similarities, Li Jieren's novel is not just a simple rewriting of the French novel, for there are also many differences in the perspectives of the two women and especially in their fate. This thesis is focusing on the reasons that can explain the major differences in the outcome of each heroine's story. First within the content of both novels, reasons based on elements differentiating the two women and on their social class. Then, studying at the author's level, we will look at reasons from a cross-cultural perspective, such as the writing objectives, literary choices and living concepts of Gustave Flaubert and Li Jieren. ; Aussitôt après que les œuvres de Gustave Flaubert ont été traduites en chinois, elles ont tout de suite suscité une grande attention de la part des lecteurs chinois. Ses pensées philosophiques, son objectivité et son exactitude dans l'écriture ont provoqué une résonance dans les milieux lettrés chinois d'alors et ont influencé profondément leurs écrits. Le traducteur-romancier chinois, Li Jieren, qui fut le premier traducteur du roman Madame Bovary, avoue qu'il s'est beaucoup inspiré du style de Flaubert présent dans ce roman. En 1935, dix ans après sa première traduction de Madame Bovary, il a commencé la rédaction de son chef-d'œuvre Rides ...

As soon as the works of Gustave Flaubert were translated into Chinese, Chinese readers immediately paid great attention to them. His philosophical thoughts, objectivity and accuracy in writing caused a resonance in Chinese literary circles of the time and profoundly influenced their writings. Chinese translator and novelist, Li Jieren, who was the first translator of Madame Bovary, admitted he was much inspired by the style of Flaubert in this novel. In 1935, ten years after the first translation of Madame Bovary, he began writing his masterpiece Ripples across stagnant water which has been considered by Chinese critics as the Chinese Madame Bovary. Astonishing similarities can be noticed between the two main characters from various aspects. Despite these similarities, Li Jieren's novel is not just a simple rewriting of the French novel, for there are also many differences in the perspectives of the two women and especially in their fate. This thesis is focusing on the reasons that can explain the major differences in the outcome of each heroine's story. First within the content of both novels, reasons based on elements differentiating the two women and on their social class. Then, studying at the author's level, we will look at reasons from a cross-cultural perspective, such as the writing objectives, literary choices and living concepts of Gustave Flaubert and Li Jieren. ; Aussitôt après que les œuvres de Gustave Flaubert ont été traduites en chinois, elles ont tout de suite suscité une grande attention de la part des lecteurs chinois. Ses pensées philosophiques, son objectivité et son exactitude dans l'écriture ont provoqué une résonance dans les milieux lettrés chinois d'alors et ont influencé profondément leurs écrits. Le traducteur-romancier chinois, Li Jieren, qui fut le premier traducteur du roman Madame Bovary, avoue qu'il s'est beaucoup inspiré du style de Flaubert présent dans ce roman. En 1935, dix ans après sa première traduction de Madame Bovary, il a commencé la rédaction de son chef-d'œuvre Rides ...

As soon as the works of Gustave Flaubert were translated into Chinese, Chinese readers immediately paid great attention to them. His philosophical thoughts, objectivity and accuracy in writing caused a resonance in Chinese literary circles of the time and profoundly influenced their writings. Chinese translator and novelist, Li Jieren, who was the first translator of Madame Bovary, admitted he was much inspired by the style of Flaubert in this novel. In 1935, ten years after the first translation of Madame Bovary, he began writing his masterpiece Ripples across stagnant water which has been considered by Chinese critics as the Chinese Madame Bovary. Astonishing similarities can be noticed between the two main characters from various aspects. Despite these similarities, Li Jieren's novel is not just a simple rewriting of the French novel, for there are also many differences in the perspectives of the two women and especially in their fate. This thesis is focusing on the reasons that can explain the major differences in the outcome of each heroine's story. First within the content of both novels, reasons based on elements differentiating the two women and on their social class. Then, studying at the author's level, we will look at reasons from a cross-cultural perspective, such as the writing objectives, literary choices and living concepts of Gustave Flaubert and Li Jieren. ; Aussitôt après que les œuvres de Gustave Flaubert ont été traduites en chinois, elles ont tout de suite suscité une grande attention de la part des lecteurs chinois. Ses pensées philosophiques, son objectivité et son exactitude dans l'écriture ont provoqué une résonance dans les milieux lettrés chinois d'alors et ont influencé profondément leurs écrits. Le traducteur-romancier chinois, Li Jieren, qui fut le premier traducteur du roman Madame Bovary, avoue qu'il s'est beaucoup inspiré du style de Flaubert présent dans ce roman. En 1935, dix ans après sa première traduction de Madame Bovary, il a commencé la rédaction de son chef-d'œuvre Rides ...

Deregulated protein and Ca2+ homeostasis underlie synaptic dysfunction and neurodegeneration in Huntington disease (HD); however, the factors that disrupt homeostasis are not fully understood. Here, we determined that expression of downstream regulatory element antagonist modulator (DREAM), a multifunctional Ca2+-binding protein, is reduced in murine in vivo and in vitro HD models and in HD patients. DREAM downregulation was observed early after birth and was associated with endogenous neuroprotection. In the R6/2 mouse HD model, induced DREAM haplodeficiency or blockade of DREAM activity by chronic administration of the drug repaglinide delayed onset of motor dysfunction, reduced striatal atrophy, and prolonged life span. DREAM-related neuroprotection was linked to an interaction between DREAM and the unfolded protein response (UPR) sensor activating transcription factor 6 (ATF6). Repaglinide blocked this interaction and enhanced ATF6 processing and nuclear accumulation of transcriptionally active ATF6, improving prosurvival UPR function in striatal neurons. Together, our results identify a role for DREAM silencing in the activation of ATF6 signaling, which promotes early neuroprotection in HD ; This work was funded by the Instituto de Salud Carlos III/CIBERNED (to J.R. Naranjo, B. Mellström, and A. Rábano), FISS-RIC RD12/0042/0019 (to C. Valenzuela), Madrid regional government/Neurodegmodels (to J.R. Naranjo), MINECO grants SAF2010-21784 and SAF2014-53412-R (to J.R. Naranjo), SAF2012-32209 (to M. Gutierrez-Rodriguez), SAF2010-14916 and SAF2013-45800-R (to C. Valenzuela), and a grant from the Swedish Research Council (J.Y. Li)