Suchergebnisse

Abstract
Background
Perfluoroalkyl and polyfluoroalkyl substances (PFAS) represent a category of pervasive and enduring environmental pollutants that present a risk to human health. Although growing evidence suggests that probiotics can potentially alleviate the adverse effects of PFAS, large cross-sectional studies on the relationship between probiotic consumption and PFAS remain lacking.

Objective
The objective of this study is to assess the association between the exposure of probiotics and serum levels of PFAS.

Methods
This analysis included individuals aged 20 and above who took part in the National Health and Nutrition Examination Survey (NHANES) between 2003 and 2018. Probiotic consumption was considered when a participant reported consuming yogurt during the two 24-h dietary recall or using a probiotic supplement in dietary supplement questionnaires over the past 30 days.

Results
This study involved 9469 adults, out of which 1333 had been exposed to probiotics. We found negative associations between probiotic consumption and serum concentrations of perfluorooctanoic acid (PFOA) (β: − 0.19, 95% CI − 0.35 to − 0.02; P = 0.027), and perfluorooctane sulfonic acid (PFOS) (β: − 0.1.27, 95% CI − 2.23 to − 0.32; P = 0.010). The consumption of probiotic supplements alone was associated with reduced perfluorononanoic acid (PFNA) (β: − 0.19, 95% CI − 0.28 to − 0.10; P < 0.001). No statistically significant association was identified between probiotic consumption and perfluorohexane sulphonic acid (PFHxS).

Conclusion
In this cross-sectional, nationally representative study, probiotic ingestion was negatively associated with several serum PFAS compounds. These findings carry substantial implications for designing interventions that target the reduction of accumulated PFAS levels in the body and mitigating the resulting adverse health effects.