One-Step Chemo-, Regio- and Stereoselective Reduction of Ketosteroids to Hydroxysteroids over Zr-Containing MOF-808 Metal-Organic Frameworks
[EN] Zr-containing MOF-808 is a very promising heterogeneous catalyst for the selective reduction of ketosteroids to the corresponding hydroxysteroids through a Meerwein-Ponndorf-Verley (MPV) reaction. Interestingly, the process leads to the diastereoselective synthesis of elusive 17 alpha-hydroxy derivatives in one step, whereas most chemical and biological transformations produce the 17 beta-OH compounds, or they require several additional steps to convert 17 beta-OH into 17 alpha-OH by inverting the configuration of the 17 center. Moreover, MOF-808 is found to be stable and reusable; it is also chemoselective (only keto groups are reduced, even in the presence of other reducible groups such as C=C bonds) and regioselective (in 3,17-diketosteroids only the keto group in position 17 is reduced, while the 3-keto group remains almost intact). The kinetic rate constant and thermodynamic parameters of estrone reduction to estradiol have been obtained by a detailed temperature-dependent kinetic analysis. The results evidence a major contribution of the entropic term, thus suggesting that the diastereoselectivity of the process is controlled by the confinement of the reaction inside the MOF cavities, where the Zr4+ active sites are located. ; Financial support by the Spanish Government is acknowledged through projects MAT2017-82288-C2-1-P and the Severo Ochoa program (SEV-2016-0683). The Microscopy Service of the Universitat Politecnica de Valencia is gratefully acknowledged for the electron microscopy images. ; Mautschke, H.; Llabrés I Xamena, FX. (2021). One-Step Chemo-, Regio- and Stereoselective Reduction of Ketosteroids to Hydroxysteroids over Zr-Containing MOF-808 Metal-Organic Frameworks. Chemistry - A European Journal. 27(41):10766-10775. https://doi.org/10.1002/chem.202100967 ; S ; 10766 ; 10775 ; 27 ; 41