Can environmental protection tax aggravate illegal pollution discharge of heavy polluting enterprises?
In: Environmental science and pollution research: ESPR, Band 29, Heft 22, S. 33796-33808
ISSN: 1614-7499
18 Ergebnisse
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In: Environmental science and pollution research: ESPR, Band 29, Heft 22, S. 33796-33808
ISSN: 1614-7499
In: Environmental science and pollution research: ESPR, Band 28, Heft 8, S. 10207-10223
ISSN: 1614-7499
In: Socio-economic planning sciences: the international journal of public sector decision-making, Band 86, S. 101451
ISSN: 0038-0121
In: Environmental science and pollution research: ESPR, Band 29, Heft 32, S. 48477-48490
ISSN: 1614-7499
In: Socio-economic planning sciences: the international journal of public sector decision-making, Band 78, S. 101055
ISSN: 0038-0121
In: Environmental science and pollution research: ESPR, Band 27, Heft 22, S. 28288-28305
ISSN: 1614-7499
In: Technological forecasting and social change: an international journal, Band 203, S. 123404
ISSN: 0040-1625
In: Socio-economic planning sciences: the international journal of public sector decision-making, Band 92, S. 101830
ISSN: 0038-0121
SSRN
In: Reproductive sciences: RS : the official journal of the Society for Reproductive Investigation, Band 27, Heft 12, S. 2232-2241
ISSN: 1933-7205
AbstractReports in recent years have suggested that adiponectin (APN) improves insulin resistance and inhibits apoptosis by activating the AMP-activated protein kinase (AMPK) pathway and the PI3K/Akt signaling pathway after binding to its receptor. This study aims to explore the mechanism by which APN reduces embryo loss rate and trophoblast apoptosis in early pregnancy of mice with polycystic ovary syndrome (PCOS). PCOS mice were subcutaneously injected with APN (10 μg mg kg−1 day−1) on 11 consecutive days from the 3rd day of pregnancy onwards to observe the change of the embryo loss rate of PCOS mice induced by APN. Quantitative real-time PCR and Western blot were used to determine the relative expressions of mRNA and the proteins AMPK, PI3K, and Akt in mouse uterine tissue. At the same time, primary cultured mouse villous trophoblast cells were used to further explore the underlying mechanisms in vitro. APN significantly reduces the pregnancy loss rate of PCOS mice. At the same time, APN increases phosphorylation and mRNA expression levels of AMPK, PI3K, and Akt in PCOS mouse uterine tissue. In addition, trophoblast cells of model mice were treated with APN and inhibitors, and APN was found to reduce trophoblast cell apoptosis by affecting the phosphorylation levels of AMPK, PI3K, Akt, and FoxO3a proteins. APN reduces the embryo loss rate and ameliorates trophoblast apoptosis in PCOS mice by affecting the AMPK/PI3K/AKT/FoxO3a signaling pathway.
In: Environmental science and pollution research: ESPR, Band 30, Heft 29, S. 74372-74385
ISSN: 1614-7499
In: Environmental science and pollution research: ESPR, Band 29, Heft 21, S. 31578-31596
ISSN: 1614-7499
In: Environmental science and pollution research: ESPR, Band 27, Heft 22, S. 28222-28246
ISSN: 1614-7499