Suchergebnisse

The water–energy–food (WEF) nexus has emerged as a leading tool for assessing integrated resource management strategies and for monitoring progress towards the WEF-related Sustainable Development Goals. A notable outcome of WEF nexus research has been the calculation of the global WEF Nexus Index, which provides a quantitative ranking of country-level WEF security for 170 nations. As valuable as this ranking is, the aggregation of country-level WEF data obscures regional differences, particularly in remote regions that are sparsely populated and differ in geography, economy, and climate. This has proven to be the case for northern Canada, which despite representing 40% of Canada's total land area, accounts for less than 1% of the Canadian population, most of whom are Indigenous. Whereas Canada ranks 5th globally in their WEF security, northern Canada, if treated independently, would rank 67th on the global WEF Nexus Index rankings. Evaluating each WEF sector independently, northern Canada would rank 22nd in water security, 90th in energy security, and 113th in food security. Our results further reveal that considerable inter-regional variability exists between northern territories and provinces, where Nunavik would rank 54th, Northwest Territories 67th, Yukon 69th, Labrador 80th, and Nunavut 107th on the global index. By highlighting these differences, we hope that this research can aid decision-makers in developing informed, regionally specific, and integrative resource policy responses that remedy rather than amplify existing WEF-related inequalities.

Abstract. Landslides threaten the safety of vehicles on highways. When
analyzing the risk of a landslide hitting moving vehicles, the spacing
between vehicles and the types of vehicles on the highway can be highly
uncertain and have often been omitted in previous studies. Using a highway slope in Hong Kong as a case study, this paper presents a method
for assessing the risk of moving vehicles being hit by a rainfall-induced landslide; this method also allows for the possible number of different types of vehicles hit by the
landslide to be investigated. In this case study, the annual failure
probability of the slope is analyzed based on historical slope failure data
from Hong Kong. The spatial impact of the landslide is evaluated based on an
empirical run-out prediction model. The consequences of the landslide are assessed using
probabilistic modeling of the traffic, which can consider uncertainties in the
vehicle spacing, vehicle types and slope failure time. Using the suggested
method, the expected annual number of vehicles and people hit by the
landslide can be conveniently calculated. This method can also be used to derive the
cumulative frequency–number of fatalities curve for societal risk
assessment. Using the suggested method, the effect of factors like the annual
failure probability of the slope and the density of vehicles on the risk level of
the slope can be conveniently assessed. The method described in this paper
can provide a new guideline for highway slope design in terms of managing
the risk of landslides hitting moving vehicles.

INTRODUCTION: Anlotinib hydrochloride is a multi-targeted receptor tyrosine kinase inhibitor that targets angiogenesis-related kinases and has already showed good safety and efficacy in some solid tumours. However, evidence on the safety and feasibility of anlotinib in patients with stage IV gastric cancer is scarce. METHODS AND ANALYSIS: This study is a single-armed and single-centred clinical study being designed to include 150 patients of stage IV gastric cancer. The patients' demographics, pathological characteristics, test results of blood, biochemistry and tumour markers before and after medication, disease-free survival and overall survival will be collected and analysed. The primary and main efficacy outcomes are objective response rate, progression-free survival, disease control rate and overall survival. The secondary efficacy outcome is safety indicator including the incidence of adverse drug reactions and adverse events after administration. ETHICS AND DISSEMINATION: Ethics approval has been obtained from the Ethics Committee at the First Affiliated Hospital (Xijing Hospital) of Fourth Military Medical University (KY20192111-F-1). The results of this study will be disseminated at several research conferences and as published articles in peer-reviewed journals. TRIAL REGISTRATION NUMBER: ChiCTR1900026291 (registration date: 29 September 2019).

A unique cluster of childhood leukemia has recently occurred around the city of Fallon in Churchill County, Nevada. From 1999 to 2001, 11 cases were diagnosed in this county of 23,982 people. Exposures related to a nearby naval air station such as jet fuel or an infectious agent carried by naval aviators have been hypothesized as potential causes. The possibility that the cluster could be attributed to chance was also considered. We used data from the Surveillance, Epidemiology, and End Results Program (SEER) to examine the likelihood that chance could explain this cluster. We also used SEER and California Cancer Registry data to evaluate rates of childhood leukemia in other U.S. counties with military aviation facilities. The age-standardized rate ratio (RR) in Churchill County was 12.0 [95% confidence interval (CI), 6.0-21.4; p = 4.3 times symbol 10(-9)]. A cluster of this magnitude would be expected to occur in the United States by chance about once every 22,000 years. The age-standardized RR for the five cases diagnosed after the cluster was first reported was 11.2 (95% CI, 3.6-26.3). In contrast, the incidence rate was not increased in all other U.S. counties with military aviation bases (RR = 1.04; 95% CI, 0.97-1.12) or in the subset of rural counties with military aviation bases (RR = 0.72; 95% CI, 0.48-1.08). These findings suggest that the Churchill County cluster was unlikely due to chance, but no general increase in childhood leukemia was found in other U.S. counties with military aviation bases.

A unique cluster of childhood leukemia has recently occurred around the city of Fallon in Churchill County, Nevada. From 1999 to 2001, 11 cases were diagnosed in this county of 23,982 people. Exposures related to a nearby naval air station such as jet fuel or an infectious agent carried by naval aviators have been hypothesized as potential causes. The possibility that the cluster could be attributed to chance was also considered. We used data from the Surveillance, Epidemiology, and End Results Program (SEER) to examine the likelihood that chance could explain this cluster. We also used SEER and California Cancer Registry data to evaluate rates of childhood leukemia in other U.S. counties with military aviation facilities. The age-standardized rate ratio (RR) in Churchill County was 12.0 [95% confidence interval (CI), 6.0-21.4; p = 4.3 times symbol 10(-9)]. A cluster of this magnitude would be expected to occur in the United States by chance about once every 22,000 years. The age-standardized RR for the five cases diagnosed after the cluster was first reported was 11.2 (95% CI, 3.6-26.3). In contrast, the incidence rate was not increased in all other U.S. counties with military aviation bases (RR = 1.04; 95% CI, 0.97-1.12) or in the subset of rural counties with military aviation bases (RR = 0.72; 95% CI, 0.48-1.08). These findings suggest that the Churchill County cluster was unlikely due to chance, but no general increase in childhood leukemia was found in other U.S. counties with military aviation bases.