Suchergebnisse

Lan Li,1 Zhenrong Ge,1 Dengke Zhang,1 Jun Kuang,2 Xiang Ma,3 Shubin Jiang1 1Coronary Care Unit, The Traditional Chinese Medicine Hospital, Xinjiang Medical University, 2Department of Cardiology, General Hospital of Xinjiang Military Command, 3Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, People's Republic of China Background: Although it has been shown to be superior to simple antithrombotic drug therapy, most patients are unable to receive timely percutaneous coronary intervention (PCI) and are treated with conventional triple antithrombotic therapy (aspirin, clopidogrel, low-molecular-weight heparin). Here, we evaluate the efficacy and safety of adding low-dose tirofiban to this regimen. Methods: A total of 1,783 patient records (unable to receive PCI) indicating non-ST-segment elevation acute coronary syndrome (NSTE-ACS) were included. A total of 882 received conventional triple antithrombotic therapy; 901 received quadruple antithrombotic therapy. Efficacy was evaluated in terms of major adverse cardiovascular event (MACE) parameters. Safety was evaluated based on the occurrence of bleeding events. Data were collected over a 6-month period post treatment. Results: The rate of occurrence of MACE was significantly lower in the quadruple antithrombotic group (10.5% versus 14.1% at 6 months, P=0.02). The log-rank test showed improved survival in the quadruple antithrombotic group. Total bleeding events were higher in the quadruple antithrombotic group (9.7%) than in the triple antithrombotic group (7.1%) (P=0.04); however, this may be attributed to increased clinically insignificant minor bleeding events. Conclusion: Quadruple antithrombotic therapy demonstrated a superior alternative for the treatment of high-risk NSTE-ACS patients failing to receive PCI. Keywords: low-dose tirofiban, non-ST-segment elevation acute coronary syndrome, quadruple drug therapy

The title alkaloids, 1 and 2, have been prepared using cross-coupling chemistries and together with various analogues they have been evaluated for their capacity to inhibit acetylcholinesterase. Contrary to an earlier report, it was found that biaryl 1 is not a significant inhibitor of this enzyme, and neither are any of its congeners, including alkaloid 2. ; We thank Jinan University, the Australian Research Council, and the Institute of Advanced Studies for financial support. H. S. K. and G. J. C. are the grateful recipients of scholarships provided by the Australian Government.

Xiang Li,1,2,* Shu-Jie An,3,* Xiao-Ling Liu,1,* Ai-Ling Ji,4 Yi Cao,5 Ying Xiang,1 Xiang-Yu Ma,1 Qin Hu,1 Zhi-Quan Yuan,1 Ya-Fei Li,1 Yuan-Gang Lu,2 Tong-Jian Cai1 1Department of Epidemiology, College of Preventive Medicine, Army Medical University (Third Military Medical University), Chongqing, People's Republic of China; 2Department of Plastic & Cosmetic Surgery, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, People's Republic of China; 3Medical Department, Xijing Hospital, Air Force Medical University (Fourth Military Medical University), Xi'an, People's Republic of China; 4Department of Preventive Medicine & Chongqing Engineering Research Center of Pharmaceutical Sciences, Chongqing Medical and Pharmaceutical College, Chongqing, People's Republic of China; 5Department of Health Economics Management, Xijing Hospital, Air Force Medical University (Fourth Military Medical University), Xi'an, People's Republic of China*These authors contributed equally to this workCorrespondence: Yuan-Gang LuDepartment of Plastic & Cosmetic Surgery, Daping Hospital, Army Medical University, 10 Changjiang Branch Road, Daping, Chongqing, 400042, People's Republic of ChinaTel +86-23-68757597Fax +86-23-68757596Email skin515@163.comTong-Jian Cai Email ctjcsl@fmmu.edu.cnBackground: Post-adolescent acne is a common skin disease faced by adults. However, whether air pollution (AP) serves as a risk factor for post-adolescent acne remains elusive.Aim: To determine the relationship between short-term AP exposure (within 7 days) and outpatient visits for post-adolescent acne.Methods: Daily outpatient visit data for post-adolescent acne and routinely AP data between 2010 and 2013 were collected from Xi'an, China. A generalized additive regression model was used to analyze the relationship between outpatient visits for post-adolescent acne and short-term ambient AP exposure. The gender-specific analyses were conducted as well.Results: Totally, 27,190 outpatient visits for post-adolescent acne were included. The results revealed that a 10 μg/m3 increase in PM10, SO2, and NO2 at lag 0– 7 day was associated with the increase of outpatient visits for post-adolescent acne at 0.84% (95% CI: 0.53%, 1.16%), 1.61% (95% CI: 0.12%, 3.10%), and 3.50% (95% CI: 1.60%, 5.40%), respectively. The significant positive associations of PM10, SO2, and NO2 were found at both single-lag models and moving average models. The gender-specific analyses showed that the effect estimates of PM10 was stronger for females than for males, while there was no observed gender difference in the effects of SO2 and NO2.Conclusion: Short-term exposure to AP was associated with increased outpatient visits for post-adolescent acne, especially for females in the effects of PM10.Keywords: short-term, air pollution, post-adolescent acne, adult acne, time-series analysis