A Landmark-based cognition strength grid model for indoor guidance
In: Survey review, Band 50, Heft 361, S. 336-346
ISSN: 1752-2706
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In: Survey review, Band 50, Heft 361, S. 336-346
ISSN: 1752-2706
In: HELIYON-D-22-09664
SSRN
In: Environmental science and pollution research: ESPR, Band 20, Heft 3, S. 1431-1440
ISSN: 1614-7499
Haiyun Zhang,1,* Yujie Liu,2,* Kehan Xu,2,* Kai Mao,1 Weidong Han,1 Feifan Xu,1 Wei Wan,2 Yajun Sun3 1Department of Laboratory Medicine, The Sixth People's Hospital of Nantong, Jiangsu 226000, People's Republic of China; 2Department of Orthopedic Oncology, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, People's Republic of China; 3Department of Laboratory Medicine, The Fourth People's Hospital of Nantong, Jiangsu 226000, People's Republic of China*These authors contributed equally to this workCorrespondence: Yajun Sun; Wei WanDepartment of Laboratory Medicine, The Fourth People's Hospital of Nantong, Chenggang Road, Jiangsu 226000, People's Republic of ChinaEmail yajun_sun1@163.com; wei_wan66@163.comIntroduction: Amphiphysin 1 (AMPH-1) is involved in endocytosis, and its expression is upregulated in osteosarcoma compared with osteofibrous dysplasia.Methods: We investigated the role of AMPH-1 in osteosarcoma cells via both gain-of-function and loss-of-function experiments.Results: Knockdown of AMPH-1 in osteosarcoma cells promoted cell cycle progression and cell proliferation and attenuated apoptosis. Notably, silencing AMPH-1 increased osteosarcoma progression in a mouse tumor model. The results obtained upon AMPH-1 knockdown and AMPH-1 overexpression indicates that AMPH-1 is involved in regulating MEK/ERK signaling.Conclusion: These data suggest that AMPH-1 plays an important role in osteosarcoma and may represent a novel therapeutic target for osteosarcoma treatment.Keywords: AMPH-1, osteosarcoma, ERK signaling pathway
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