Este trabajo se basa en la aplicación de métodos de enseñanza a una programación didáctica pensada para un curso de 4º de la E.S.O de la asignatura Matemáticas orientadas a las enseñanzas académicas. Para llevarla acabo he extraído información de documentos legislativos (ORDEN EDU/362/2015 y Real Decreto 1105/2014), sobre todo en cuanto a objetivos y contenido se refiere. Sin embargo el desarrollo de la Metodología en la cual se fundamenta el trabajo, así como la evaluación y el resto de los puntos que se desarrollan en la unidad didáctica son obra de la autora . ; Departamento de Matemática Aplicada ; Máster en Profesor de Educación Secundaria Obligatoria y Bachillerato, Formación Profesional y Enseñanzas de Idiomas
O objeto desta investigação é desenvolver uma lista de recomendações e boas práticas que permita a governos, investidores privados e partes interessadas ferroviárias que tomem melhores decisões e mais eficientes na implementação de novas linhas ferroviárias de alta velocidade contratadas através de parceiras público-privadas. A metodologia de investigação baseia-se em estudos de caso exploratórios e coletivos e na identificação de fatores críticos de sucesso. Assim, esta investigação analisou a linha de alta velocidade que liga Amesterdão à fronteira com a Bélgica e o troço Lisboa-Poceirão-Caia. Este artigo permitiu desenvolver a seguinte lista de recomendações e boas práticas. Cooperação transfronteiriça para os troços internacionais, um único contrato para a subestrutura e para a superestrutura, um contrato independente para os sistemas de sinalização e comunicações.
The Colombian Government has made significant progress in the implementation of effective processes, practices, and methodologies for public investment management (PIM). A 2011 IMF-published report ranked Colombia among the top 5 countries with best PIM practices out of a sample of 71 low- and middle-income countries (Dabla-Norris and others, 2011). The report assessed the following 4 key features: (a) strategic guidance and project review, (b) project selection and budgeting, (c) project implementation, and (d) project evaluation and auditing. Colombia was deemed to have achieved a good performance on 3 out of the 4 key features. Nevertheless, the country's PIM system still faces the need for areas of improvement identified by the World Bank's PIM framework. This framework allows for identification of not only the presence of must-have features in PIM systems that are key to promoting effective and efficient public investment but also if those features are implemented in the field and if they have achieved their intended purpose. In the case of Colombia, the main challenges identified were related to the broad implementation of tools designed, particularly for management of public investment projects as well as with the fractioning of standards and practices, and the overemphasis placed on formal controls during the formulation and project implementation stages. In addition, the country PIM processes had weaknesses in terms of the review and ex post project evaluation. This document summarizes the main findings of a PIM study carried out in Colombia in 2015. The document includes an analytical framework for assessing public investment management and presents the assessment results as well as improvement recommendations to strengthen the institutional set-up to increase the effectiveness and efficiency of public investment in Colombia.
7 páginas, 1 figura, 7 esquemas, 1 tabla.-- El PDF es la versión post-print. ; The concept of molecular simplification as a drug design strategy to shorten synthetic routes, while keeping or enhancing the biological activity of the lead drug, has been applied to (+)-muconin, an acetogenin with remarkable cytotoxicity. A novel approach that enables the stereoselective synthesis of such a natural compound or its enantiomer from a common precursor is described. An additional advantage of the method is complete stereochemical control and the decrease in the number of chemical steps required, thus providing an enhancement of the overall yield. Antiproliferative studies against the human solid tumor cell lines showed that the aliphatic chain-THF/THP fragment of (+)-muconin has modest cytotoxic activity. The strategy opens the way to preparing novel bioactive acetogenin analogues by shorter synthetic routes. ; The authors thank the MYCT (PPQ2002- 04361-C04-02) of Spain and the Canary Islands Government for supporting this research. F.R.P.C. thanks CajaCanarias for a FPI fellowship. R.C. thanks the Spanish MEC for a FPU fellowship. J.M.P. thanks ICIC for a postdoctoral fellowship. ; Peer reviewed
