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Juvenile idiopathic arthritis (JIA) differs markedly from adult rheumatoid arthritis. It is not a single disease, but an exclusion diagnosis that gather together all forms of arthritis that begin before the age of 16 years, persist for more than 6 weeks, and are of unknown origin. The advent of the new biological treatments has dramatically changed both the observed responses to treatment and the expectations of therapies. The implementation of an adequate legislation as well as the presence of international research networks of pediatric rheumatology have contributed to foster the conduct of controlled clinical trials and the development of validated outcome measures. This review will currently describe the methodological approach for performing clinical trials in JIA as well as the current available drug treatment.

AbstractWe estimate the impact of a matched savings account program on high school students' college enrollment and persistence through a randomized controlled trial carried out in Italy. The tested program (Percorsi) provided low‐income high school students with a 4:1 match rate for savings dedicated to higher education expenditures and required that they attended financial education classes. The program increased rates of enrollment and persistence in university by about nine percentage points. Effects were even larger for vocational school students, who have poorer social backgrounds and lower academic preparation. Incentivized savings programs have potential to reduce social disparities in higher education participation, though the lower saving capacity of poorer households can generate regressivity in program design.

Mental disease is increasing worldwide and people who suffer from it show lower employment rates and lower earnings. Various approaches have been tried to increase the employment rate of people with mental disease. In the US, empirical studies show that individual placement and support(IPS)—a rapid transition to the job market, with some external assistance—is effective in increasing the employment rate of the mentally ill. Europe lacks such evidence. The study assesses the impact of an IPS-like program undertaken in Italy on the employment rate of people with severe mental illness. The analysis is based on a RCT that tests whether offering people with severe mental illness the support of a "job coach" increases their chances of being employed. Moreover, using a battery of tests—one of which is made available by the RCT itself—we show that the large non-compliance with the protocol showed by the RCT is ignorable. This motivates estimating the impact of carrying out a traineeship during the experimental period on employment using non-experimental methods. The study finds that the availability of a coach boosts the patients' chances of finding a traineeship during the experimental period; moreover, undertaking a traineeship almost doubles the likelihood of being at work one year later. JEL CODES: J78, J48, J38