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The purpose of this article is to review current empirical research on the effectiveness of drug treatment programs, particularly those for prisoners, parolees, and probationers. The authors reviewed empirical research published after the year 2000 that they classified as Level 3 or higher on the Maryland Scale. Participants in cognitive-behavioral therapy (CBT), therapeutic communities, and drug courts had lower rates of drug use and crime than comparable individuals who did not receive treatment. Several different types of pharmacological treatments were associated with a reduced frequency of drug use. Those who received contingency management tended to use drugs less frequently, particularly if they also received cognitive-behavioral therapy. Finally, researchers reported that drug use and crime were lower among individuals whose treatment was followed by an aftercare program. Effective treatment programs tend to (a) focus on high-risk offenders, (b) provide strong inducements to receive treatment, (c) include several different types of interventions simultaneously, (d) provide intensive treatment, and (e) include an aftercare component.