Suchergebnisse

Examines the impact of the Scottish legacy on North American cultures and heritage. During the past four decades, growing interest in North Americans' cultural and ancestral ties to Scotland has produced hundreds of new Scottish clan and heritage societies. Well over 300 Scottish Highland games and gatherings annually take place across the U.S. and Canada. Transatlantic Scots is a multidisciplinary collection that studies the regional organization and varied expressions of the Scottish Heritage movement in the Canadian Maritimes, the Great Lakes, New England, and the American South. From diverse perspectives, authorities in their fields consider the modeling of a Scottish identity that distances heritage celebrants from prevalent visions of whiteness. Considering both hyphenated Scots who celebrate centuries-old transmission of Scottish traditions and those for whom claiming or re-claiming a Scottish identity is recent and voluntary, this book also examines how diaspora themes and Highland imagery repeatedly surface in regional public celebrations and how traditions are continually reinvented through the accumulation of myths. The underlying theoretical message is that ethnicity and heritage survive because of the flexibility of history and tradition. This work is a lasting contribution to the study of ethnicity and identity, the renegotiation of history and cultural memory into heritage, and the public performance and creation of tradition.

AbstractPrevious genetic association studies have failed to identify loci robustly associated with sepsis, and there have been no published genetic association studies or polygenic risk score analyses of patients with septic shock, despite evidence suggesting genetic factors may be involved. We systematically collected genotype and clinical outcome data in the context of a randomized controlled trial from patients with septic shock to enrich the presence of disease-associated genetic variants. We performed genomewide association studies of susceptibility and mortality in septic shock using 493 patients with septic shock and 2442 population controls, and polygenic risk score analysis to assess genetic overlap between septic shock risk/mortality with clinically relevant traits. One variant, rs9489328, located in AL589740.1 noncoding RNA, was significantly associated with septic shock (p = 1.05 × 10–10); however, it is likely a false-positive. We were unable to replicate variants previously reported to be associated (p < 1.00 × 10–6 in previous scans) with susceptibility to and mortality from sepsis. Polygenic risk scores for hematocrit and granulocyte count were negatively associated with 28-day mortality (p = 3.04 × 10–3; p = 2.29 × 10–3), and scores for C-reactive protein levels were positively associated with susceptibility to septic shock (p = 1.44 × 10–3). Results suggest that common variants of large effect do not influence septic shock susceptibility, mortality and resolution; however, genetic predispositions to clinically relevant traits are significantly associated with increased susceptibility and mortality in septic individuals.