Suchergebnisse

BACKGROUND: The human papillomavirus (hpv) is a common sexually transmitted infection and a primary cause of cervical cancer. The Government of Canada has set a target of reaching 90% hpv vaccine coverage among adolescents by 2025. Here, we examine hpv vaccine uptake in school-based immunization programs across Canada and explore how achieving the 90% target could affect the future incidence of cervical cancer, mortality, and health system expenditures in a cohort of Canadian women. METHODS: Data for hpv vaccine uptake in the most recent reported school year available in each jurisdiction were provided in 2017 by jurisdictional school-based immunization programs and were used to estimate a national weighted average of 67%. The OncoSim microsimulation model (version 2.5) was used to compare 3 different levels of hpv vaccine uptake (0%, 67%, 90%) on health and economic outcomes for a hypothetical cohort of all 5- to 10-year-old girls in Canada in 2015. RESULTS: Vaccine uptake for girls in school-based programs varied from 55.0% to 92.0% in the jurisdictions reviewed. The OncoSim model projects that increasing uptake to 90% from 67% would result in a 23% reduction in cervical cancer incidence rates (to 3.1 cases from 4.0 cases per 100,000, averaged across the lifetime of the cohort) and a 23% decline in the average annual mortality rate (to 1.0 deaths from 1.3 deaths per 100,000). Finally, the model projects that the health system will incur a cost of $9 million (1% increase) during the lifetime of the cohort if uptake is increased to 90% from 67%. Costs are discounted (1.5%) and expressed in 2016 Canadian dollars. Costs reflect the payer perspective. CONCLUSIONS: Our model shows that increasing hpv vaccine uptake to 90% from current levels for girls in school-based immunization programs could result in substantial reductions in the future incidence and mortality rates for cervical cancer in Canada.

With a goal of achieving net-zero emissions by developing Smart Cities (SCs) and industrial decarbonization, there is a growing desire to decarbonize the renewable energy sector by ac-celerating green buildings (GBs) construction, electric vehicles (EVs), and ensuring long-term sta-bility, with the expectation that emissions will need to be reduced by at least two thirds by 2035 and by at least 90% by 2050. Implementing GBs in urban areas and encouraging the use of EVs are cor-nerstones of transition towards SCs, and practical actions that governments can consider to help with improving the environment and develop SCs. This paper investigates different aspects of smart cities development and introduces new feasible indicators related to GBs and EVs in design-ing SCs, presenting existing barriers to smart cities development, and solutions to overcome them. The results demonstrate that feasible and achievable policies such as the development of the zero-energy, attention to design parameters, implementation of effective indicators for GBs and EVs, implementing strategies to reduce the cost of production of EVs whilst maintaining good quality standards, load management, and integrating EVs successfully into the electricity system, are important in smart cities development. Therefore, strategies to governments should consider the full dynamics and potential of socio-economic and climate change by implementing new energy policies on increasing investment in EVs, and GBs development by considering energy, energy, techno-economic, and environmental benefits.

With a goal of achieving net-zero emissions by developing Smart Cities (SCs) and industrial decarbonization, there is a growing desire to decarbonize the renewable energy sector by accelerating green buildings (GBs) construction, electric vehicles (EVs), and ensuring long-term stability, with the expectation that emissions will need to be reduced by at least two thirds by 2035 and by at least 90% by 2050. Implementing GBs in urban areas and encouraging the use of EVs are cornerstones of transition towards SCs, and practical actions that governments can consider to help with improving the environment and develop SCs. This paper investigates different aspects of smart cities development and introduces new feasible indicators related to GBs and EVs in designing SCs, presenting existing barriers to smart cities development, and solutions to overcome them. The results demonstrate that feasible and achievable policies such as the development of the zero-energy, attention to design parameters, implementation of effective indicators for GBs and EVs, implementing strategies to reduce the cost of production of EVs whilst maintaining good quality standards, load management, and integrating EVs successfully into the electricity system, are important in smart cities development. Therefore, strategies to governments should consider the full dynamics and potential of socio-economic and climate change by implementing new energy policies on increasing investment in EVs, and GBs development by considering energy, energy, techno-economic, and environmental benefits.

The Canadian Partnership Against Cancer was created in 2007 by the federal government to accelerate cancer control across Canada. Its OncoSim microsimulation model platform, which consists of a suite of specific cancer models, was conceived as a tool to augment conventional resources for population-level policy- and decision-making. The Canadian Partnership Against Cancer manages the OncoSim program, with funding from Health Canada and model development by Statistics Canada.