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[EN] The Mediterranean agro-food systems need to be properly managed. A promising pathway is the transition towards more sustainable food systems through agroecology, which represents the ecology of food systems. In this paper, the state-of-the-art of agroecology is described for three representative euro-Mediterranean countries: Italy, Greece, and Spain. The analysis has been partly based on results of a dedicated literature search and partly on grey literature and expert knowledge. After an overview of the history of agroecology, targeted research and education, collective action (political and social), and some agroecological practices in the three countries are presented. These countries share a rather similar use of the term "agroecology", but they differ regarding (i) the existence/extent of strong civil and social movements; (ii) the type of study/educational programmes, and the relative importance of different scientific disciplines and their evolution; (iii) the development of political support and legal frameworks; and (iv) the elaboration of concepts to rediscover traditional practices and apply new ones, often taken from the organic agriculture sector. Agroecology is an emerging concept for the Mediterranean agricultural sector, with huge potential due to the peculiar socio-cultural, bio-physical, and political-economic features of the region. To boost agroecology in Mediterranean Europe, better networking and engagement of different actors within a coherent institutional framework supporting the transition is strongly needed. ; Migliorini, P.; Gkisakis, V.; Gonzálvez, V.; Raigón Jiménez, MD.; Bàrberi, P. (2018). Agroecology in Mediterranean Europe: Genesis, State and Perspectives. Sustainability. 10(8). https://doi.org/10.3390/su10082724 ; S ; 2724 ; 10 ; 8

In rheumatoid arthritis (RA), a key event is infiltration of inflammatory immune cells into the synovial lining, possibly aggravated by dysregulation of cellular adhesion molecules. Therefore, single nucleotide polymorphisms of 14 genes involved in cellular adhesion processes (CAST, ITGA4, ITGB1, ITGB2, PECAM1, PTEN, PTPN11, PTPRC, PXN, SELE, SELP, SRC, TYK2, and VCAM1) were analyzed for association with RA. Association analysis was performed consecutively in three European RA family sample groups (Nfamilies = 407). Additionally, we investigated differential allelic expression, a possible functional consequence of genetic variants. SELP (selectin P, CD62P) SNP-allele rs6136-T was associated with risk for RA in two RA family sample groups as well as in global analysis of all three groups (ptotal = 0.003). This allele was also expressed preferentially (p<10-6) with a two- fold average increase in regulated samples. Differential expression is supported by data from Genevar MuTHER (p1 = 0.004; p2 = 0.0177). Evidence for influence of rs6136 on transcription factor binding was also found in silico and in public datasets reporting in vitro data. In summary, we found SELP rs6136-T to be associated with RA and with increased expression of SELP mRNA. SELP is located on the surface of endothelial cells and crucial for recruitment, adhesion, and migration of inflammatory cells into the joint. Genetically determined increased SELP expression levels might thus be a novel additional risk factor for RA. ; The work presented in this paper was made possible by funding from the German Federal Ministry of Education and Research (BMBF, PtJ-Bio, 1315883, www.bmbf.de). This project was also supported by grant no. 7692/1187 from the Sa¨chsische Aufbaubank–Fo¨rderbank (www.sab.sachsen.de), by grant no. 4212/ 04-04 from the European Fund for Regional Development (EFRE, ec.europa.eu), by the German Federal Ministry for Education and Research (Hochschul- und Wissenschaftsprogramm; ''Kompetenznetz Rheuma'' 01GI9949 to IM), by the Rosa-Luxemburg-Stiftung (www.rosalux.de) and by the Foundation for Science and Technology, Portugal (grant SFRH/BD/23304/2005, www.fct.pt). PA, MS and HK were also supported by LIFE – Leipzig Research Center for Civilization Diseases (life.uni-leipzig.de), Universita¨t Leipzig. LIFE is funded by means of the European Union, by the European Regional Development Fund (ERDF) and by means of the Free State of Saxony within the framework of the excellence initiative.