Suchergebnisse

AbstractGanoderma lucidum (GL) is a prominent medicinal mushroom in traditional Chinese medicine, known for its potent antitumor properties. This study aimed to illustrate the efficacy of GL extracts (GLE) on treating endometrial cancer (EC) and explore the underlying mechanisms via network pharmacology and experimental validation. Network pharmacological analysis was conducted to explore the therapeutic efficacy and mechanisms of GL on EC. In vitro experimental validation was performed on human endometrial cancer cell lines HEC-1-A and KLE. Network pharmacology revealed that key targets of GL against EC were primarily associated with the Rap1 signaling pathway. In in vitro experiments, GLE or GGTI-298 (a GTPase inhibitor) treatment inhibited cell proliferation and migration, promoted cell apoptosis, increased caspase-3 level, and arrested cell cycle in G1 phase in HEC-1-A and KLE cells. GLE increased the protein expression of Rap1-GTP, p-AKT, and p-ERK2 in HEC-1-A and KLE cells. Moreover, GGTI-298 enhanced the effects of GLE on suppressing the malignant progression of EC cells and on activating Rap1 signaling pathway. GLE inhibited the malignant progression of EC cells probably via activating the Rap1 signaling pathway.

We drew on affective events theory to investigate the ways in which workplace fun motivates employees and improves their job performance. Analyzing the data collected from supervisor–knowledge worker subordinate dyads in high-tech organizations in mainland China and Taiwan, we
found that employees' perceived person–organization value congruence moderated the relation between workplace fun and employees' job performance, and this effect was mediated through their experienced fun. We discuss the theoretical and managerial implications of this mediated moderation
mechanism.

This research explores the linking mechanisms and conditional processes underlying the relationship between psychological voice climate and individual change readiness. In accordance with the social identity theory, we argued that normative commitment would mediate the relationship between psychological voice climate and individual change readiness; furthermore, work engagement would moderate the proposed indirect effect. Two-wave survey data were collected from 187 full-time employees in a government-owned institute of research and development and were adopted for moderated mediation analysis. The results showed that normative commitment mediates the relationship between psychological voice climate and individual change readiness. Furthermore, work engagement strengthens the effect of psychological voice climate on individual change readiness in an indirect manner via normative commitment. Based on the findings, the theoretical implications and practical suggestions were discussed.

This thesis talks about Chinese harmonious culture in three aspects. The first aspect is the contents, characteristics and functions of Chinese harmonious culture. The second aspect is to discuss two basic theory recourse of Chinese harmonious culture, one is its traditional culture theory, and another is the western culture theory. The third aspect is to analyze the method which China government should pay more attention to their progress of promote culture development.

Purpose
– The purpose of this paper is to review a sample of the literature relating to the financial impacts of supply chain management (SCM) and suggest future research directions.


Design/methodology/approach
– 49 research articles between 1990 and 2011 are collected from various academic databases and online sources. By conducting content analysis, empirical findings on the relationship between SCM and firm-level financial performance are summarized and classified. Performance drivers are identified from the literature to guide future SC practices.


Findings
– Both accounting- and market-based financial performances are closely related to the effectiveness of SCM. As important performance drivers, sourcing strategy, information technology (IT), SC integration, and external relationships play critical roles to improve firm-level financial performance. In particular, optimal levels of outsourceability, SC alignment and integration with IT infrastructure, and SC relationship management are essential to realize full financial advantages of effective SCM.


Practical implications
– A better understanding and demonstration on how SCM makes positive contributions to financial performance help SCM managers to better communicate with top management and substantiate their roles in the organization.


Originality/value
– To the authors' best knowledge, this paper is the first and the most comprehensive literature review in a much-needed research area. A number of performance drivers are identified to provide practical guidance. Some promising research areas are suggested for further investigation.

Rubber farming, land rental market, land use choice, intercropping, ecosystem protection. - Kautschuk, Landmietmarkt, Landnutzung, Zwischenfruchtbau, Ökosystem-Schutz