Suchergebnisse

Retinal arteriolar narrowing increases with age and predict adverse cardiovascular outcomes. Telomere length keeps track of the division of somatic cells and is a biomarker of biological age. We investigated to what extent retinal arteriolar diameters are associated with biological age, as captured by leukocyte telomere length (LTL). In 168 randomly selected Flemish participants from the family-based population study FLEMENGHO (mean age, 46.2 years) at baseline, of whom 85 underwent a follow-up examination (median, 4.1 years), we post-processed nonmydriatic retinal photographs and measured LTL. In men only, central retinal arteriolar equivalents (CRAE) and arteriole-to-venule ratio (AVR) were associated with LTL with stronger associations at higher age and body mass index. In men aged 57.6 years (75th percentile) a 20% shorter LTL was associated with a decrease in CRAE of 4.57µm. A 20% shorter LTL was associated with a decrease of 5.88µm in CRAE at a BMI of 29.9kg/m2 (75th percentile). Similar associations were observed between AVR and LTL. In women, no retinal microvascular traits were associated with LTL. Retinal arteriolar narrowing in men but not in women is associated with biological age. Our fndings support the idea that avoiding overweight contributes to maintaining a healthier microcirculation. ; The European Union [HEALTH-F7-305507 HOMAGE] and the European Research Council, Advanced Researcher Grant [2011-294713-EPLORE] and Proof-of-Concept Grant [713601-uPROPHET] and the Fonds voor Wetenschappelijk Onderzoek Vlaanderen, Ministry of the Flemish Community, Brussels, Belgium [G.0881.13 and G.088013] currently support the Studies Coordinating Centre in Leuven. Telomere measurements were funded by the European Research Council [ERC-2012-StG.310898] and by the Fonds voor Wetenschappelijk Onderzoek Vlaanderen, Ministry of the Flemish Community, Brussels, Belgium [G073315N and G073409N]. Dr Cox is a postdoctoral fellow of the Fonds voor Wetenschappelijk Onderzoek Vlaanderen, Ministry of the Flemish Community, Brussels, Belgium supported by grant 12Q0517N. The authors gratefully acknowledge the contribution of the nurses working at the examination center (Linda Custers, Marie-Jeanne Jehoul, Daisy Thijs, and Hanne Truyens) and the clerical staff at the Studies Coordinating Centre (Vera De Leebeeck, Yvette Piccart, and Renilde Wolfs).