Suchergebnisse

Since 2007 Kiluanji Kia Henda's artworks have been shown extensively on the international art circuit and included in exhibitions from Guangzhou to São Paulo, from Luanda to Venice. By considering some notable art projects and exhibition experiences that have occurred in this compressed time span and these different locations, this essay addresses the young Angolan artist's engagement with the perils and possibilities of art practice as it transverses multiple art worlds. Kia Henda's artworks engage with the potential of mis-seeing, the visual equivalent of mistranslation, in cultural exchanges between Angola and the larger world.

At the Edge of Ruin: Seeing Art Under Perpetual Conflict engages four different art practices that are embedded in current political conflicts and struggles over abuses of power: the seemingly endless warfare in Palestine, the worsening refugee crisis in Europe, the racial injustices of the U.S. criminal court system, and the ongoing environmental catastrophe in the Democratic Republic of the Congo (DRC). Focusing on artworks by Emily Jacir, Kader Attia, collaborators Keith Calhoun and Chandra McCormick, and Sammy Baloji, the project considers what insights these art practices can give into the current global conditions of both art and of social and political unrest.At the Edge of Ruin offers a response to the recent thematic emphasis of global art discourse. Artworks shown at recent large-scale global art exhibitions such as the Venice Biennale or dOCUMENTA, and through museum initiatives like the new global art programs at the Tate Modern and the Guggenheim, have increasingly focused on the disasters and conflicts that roil the 21st Century. Yet contemporary art scholarship has largely failed to consider how global art is being linked to conflict and crises and to grapple with the challenges and possibilities this poses for art interpretation. Instead, artworks tackling different geopolitical issues, for instance, the racialized politics of the mass incarceration of African Americans or the economic and labor issues within immigration struggles in France, are being shown alongside each other in international art venues with little attention paid to how these practices are producing and circulating knowledge about such disparate practices and crises. This project utilizes the conflicted space of global art to better understand worldwide unrest and turmoil. It develops a model of interpretation that investigates unfolding current events and the histories from which they spring through the responses being made in art practices.

This is a moving story of the experiences of 2 brave little girls during the days of the Selma civil rights movement. Now as adult women, they recall their involvement as children in the stirring church meetings and marches, and their relationship with Martin Luther King Jr., and the murders of 2 white Northern clergyman.

Monitoring the spread of SARS-CoV-2 and reconstructing transmission chains has become a major public health focus for many governments around the world. The modest mutation rate and rapid transmission of SARS-CoV-2 prevents the reconstruction of transmission chains from consensus genome sequences, but within-host genetic diversity could theoretically help identify close contacts. Here we describe the patterns of within-host diversity in 1181 SARS-CoV-2 samples sequenced to high depth in duplicate. 95.1% of samples show within-host mutations at detectable allele frequencies. Analyses of the mutational spectra revealed strong strand asymmetries suggestive of damage or RNA editing of the plus strand, rather than replication errors, dominating the accumulation of mutations during the SARS-CoV-2 pandemic. Within- and between-host diversity show strong purifying selection, particularly against nonsense mutations. Recurrent within-host mutations, many of which coincide with known phylogenetic homoplasies, display a spectrum and patterns of purifying selection more suggestive of mutational hotspots than recombination or convergent evolution. While allele frequencies suggest that most samples result from infection by a single lineage, we identify multiple putative examples of co-infection. Integrating these results into an epidemiological inference framework, we find that while sharing of within-host variants between samples could help the reconstruction of transmission chains, mutational hotspots and rare cases of superinfection can confound these analyses.

Monitoring the spread of SARS-CoV-2 and reconstructing transmission chains has become a major public health focus for many governments around the world. The modest mutation rate and rapid transmission of SARS-CoV-2 prevents the reconstruction of transmission chains from consensus genome sequences, but within-host genetic diversity could theoretically help identify close contacts. Here we describe the patterns of within-host diversity in 1181 SARS-CoV-2 samples sequenced to high depth in duplicate. 95.1% of samples show within-host mutations at detectable allele frequencies. Analyses of the mutational spectra revealed strong strand asymmetries suggestive of damage or RNA editing of the plus strand, rather than replication errors, dominating the accumulation of mutations during the SARS-CoV-2 pandemic. Within- and between-host diversity show strong purifying selection, particularly against nonsense mutations. Recurrent within-host mutations, many of which coincide with known phylogenetic homoplasies, display a spectrum and patterns of purifying selection more suggestive of mutational hotspots than recombination or convergent evolution. While allele frequencies suggest that most samples result from infection by a single lineage, we identify multiple putative examples of co-infection. Integrating these results into an epidemiological inference framework, we find that while sharing of within-host variants between samples could help the reconstruction of transmission chains, mutational hotspots and rare cases of superinfection can confound these analyses. ; This work was funded by COG-UK, supported by funding from the Medical Research Council (MRC) part of UK Research & Innovation (UKRI), the National Institute of Health Research (NIHR) and Genome Research Limited, operating as the Wellcome Sanger Institute;

Monitoring the spread of SARS-CoV-2 and reconstructing transmission chains has become a major public health focus for many governments around the world. The modest mutation rate and rapid transmission of SARS-CoV-2 prevents the reconstruction of transmission chains from consensus genome sequences, but within-host genetic diversity could theoretically help identify close contacts. Here we describe the patterns of within-host diversity in 1181 SARS-CoV-2 samples sequenced to high depth in duplicate. 95.1% of samples show within-host mutations at detectable allele frequencies. Analyses of the mutational spectra revealed strong strand asymmetries suggestive of damage or RNA editing of the plus strand, rather than replication errors, dominating the accumulation of mutations during the SARS-CoV-2 pandemic. Within- and between-host diversity show strong purifying selection, particularly against nonsense mutations. Recurrent within-host mutations, many of which coincide with known phylogenetic homoplasies, display a spectrum and patterns of purifying selection more suggestive of mutational hotspots than recombination or convergent evolution. While allele frequencies suggest that most samples result from infection by a single lineage, we identify multiple putative examples of co-infection. Integrating these results into an epidemiological inference framework, we find that while sharing of within-host variants between samples could help the reconstruction of transmission chains, mutational hotspots and rare cases of superinfection can confound these analyses.