Suchergebnisse

The World Heritage List was created as a result of the need to protect and conserve cultural and natural heritage. The Ohrid region is one of only 28 sites on UNESCO's World Heritage List that are both cultural and natural sites. Ohrid is one of the oldest human settlements in Europe, boasting exquisite medieval religious architecture, as well as urban architecture from the 18th and 19th centuries. The site of Plaošnik is a large archaeological and historic location in Ohrid's old town that witnessed all cultural eras from prehistory to Ottoman, but most importantly it was the location of the oldest Slavic monastery and the first Slavic University in the Balkans. In 2007, the Ministry of Culture of the Republic of Macedonia prepared a controversial plan of activities for the instauration of St. Clement's University at Plaošnik. The main interest of this study is the position of cultural heritage in the evolution of a town, and the treatment of heritage in this process, shown through the case of Plaošnik; it focuses on the influence of pressure for (re)development projects on the key elements of an area recognized by the World Heritage List, as well as the influence of the World Heritage List, as an international legal instrument, on the preservation of these features.

The important political and social changes in Serbia in the early 21st century started a process of democratisation, establishing closer ties with Europe, which contributed to intensified efforts for ratifying international conventions in the field of heritage protection and management from 2007 onwards.1 However, despite positive efforts, the protection and preservation of the cultural heritage in Serbia still show signs of a transitional phase with many of the general problems well-known in the former Eastern European countries, as well as specific conditions which are the result of recent political conflicts in the region, presenting a risk to the preservation of heritage. In addition, the cultural heritage in Serbia is also exposed to quite specific risks connected with an extremely acute economic crisis, which marked all activities of the heritage protection service during the 1990s. This is reflected in the problems of collaboration between official institutions and civil organisations. A crucial problem is non-compliance of the current Law on Cultural Properties from 19942 with international recommendations, and there is an urgent need to revise this act.

Hermann's tortoise (Testudo hermanni) is among the conservation priorities in the European Union. Consequently, it is included in Annexes II and IV of the EU Habitats Directive, Annex II of the Bern Convention, and Annex II of the CITES Convention. Hermann's tortoise conservation programs compile insights on the threats affecting population viability, along with factors shaping the species' distribution. Serbian populations of the eastern subspecies (Testudo hermanni boettgeri) seem numerous and therefore prosperous, but recent population viability analyses revealed that they are susceptible to rapid demographic changes and/or habitat destruction. This implies the need for effective population monitoring and protection, as well as mapping and preservation of suitable habitats. In this paper we summarized current knowledge about the geographic distribution of Hermann's tortoise in Serbia and modeled its ecological niche. Our results corroborate and uphold the known species' distribution in Serbia. Most suitable habitats are situated in the lowland areas of eastern, central and southern Serbia, under semi-open habitats, such as pastures and shrubs, broadleaf forests, and all successional stages in between. The results provided in this paper should be considered in the selection and shaping of NATURA 2000 sites in Serbia.

Insufficient alveolar gas exchange capacity is a major contributor to lung disease. During lung development, a population of distal epithelial progenitors first produce bronchiolar-fated and subsequently alveolar-fated progeny. The mechanisms controlling this bronchiolar-to-alveolar developmental transition remain largely unknown. We developed a novel grafting assay to test if lung epithelial progenitors are intrinsically programmed or if alveolar cell identity is determined by environmental factors. These experiments revealed that embryonic lung epithelial identity is extrinsically determined. We show that both glucocorticoid and STAT3 signalling can control the timing of alveolar initiation, but that neither pathway is absolutely required for alveolar fate specification; rather, glucocorticoid receptor and STAT3 work in parallel to promote alveolar differentiation. Thus, developmental acquisition of lung alveolar fate is a robust process controlled by at least two independent extrinsic signalling inputs. Further elucidation of these pathways might provide therapeutic opportunities for restoring alveolar capacity. ; Medical Research Council (G0900424, ER), the March of Dimes (5-FY11-119, ER), the Wellcome Trust (093029, ER), Newton Trust (14.07h, ER), Wellcome Trust PhD programme for Clinicians (MN), Postdoctoral Fellowship from the Government of the Basque Country (UL), MRC studentship (RVR), British Heart Foundation Studentship (EJB), COST BM1201. Core grants from the Wellcome Trust (092096) and Cancer Research UK (C6946/A14492). ; This is the final version of the article. It first appeared from the Company of Biologists at http://dx.doi.org/10.1242/dev.134023.