Suchergebnisse

AbstractIntroductionAIDS‐related deaths in people living with HIV/AIDS have been decreasing in number since the introduction of combination antiretroviral treatment (cART). However, data on recent causes of death in the Asia‐Pacific region are limited. Hence, we analysed and compared AIDS‐related and non‐AIDS–related mortality in high‐ and low‐income settings in the region.MethodsPatients from the TREAT Asia HIV Observational Database (TAHOD) and Australian HIV Observational Database (AHOD) receiving cART between 1999 and 2017 were included. Causes of death verification were based on review of the standardized Cause of Death (CoDe) form designed by the D:A:D group. Cohorts were grouped as AHOD (all high‐income sites), TAHOD‐high (high/upper‐middle income countries) and TAHOD‐low (lower‐middle income countries). TAHOD sites were split into high/upper‐middle income and lower‐middle income country settings based on World Bank classifications. Competing risk regression was used to analyse factors associated with AIDS and non‐AIDS–related mortality.ResultsOf 10,386 patients, 522 died; 187 from AIDS‐related and 335 from non‐AIDS–related causes. The overall incidence rate of deaths during follow‐up was 0.28 per 100 person‐years (/100 PYS) for AIDS and 0.51/100 PYS for non‐AIDS. Analysis indicated that the incidence rate of non‐AIDS mortality decreased from 0.78/100 PYS to 0.37/100 PYS from year groups 2003 to 2007 to 2013 to 2017 (p < 0.001). Similarly, incidence rates of AIDS‐related deaths decreased from 0.51/100 PYS to 0.09/100 PYS from year groups 2003 to 2007 to 2013 to 2017 (p < 0.001). More recent years of follow‐up were associated with reduced hazard for non‐AIDS mortality (2008 to 2012: aSHR (adjusted sub‐hazard ratio) 0.72, 95% confidence interval (CI) 0.54 to 0.96, p = 0.027; 2013 to 2017: aSHR 0.64, 95% CI 0.47 to 0.87, p = 0.004) compared to years 2003 to 2007. The AHOD cohort had almost twice the hazard of non‐AIDS mortality compared to TAHOD‐low (lower‐middle income sites) (aSHR 1.72, 95% CI, 1.20 to 2.46, p = 0.003); there were no differences between cohorts for AIDS‐related mortality (p = 0.834).ConclusionAIDS and non‐AIDS–related mortality rates have decreased over the past years in the Asia‐Pacific region. There is a greater risk for non‐AIDS–associated deaths in the AHOD cohort compared to lower‐middle income settings in TAHOD.

In a time of energy transition, this article summarizes the most relevant conclusions obtained from the SENSIBLE project [3], which aimed to demonstrate that the 2030 EU energy policy targets are achievable, and that distributed energy storage has a crucial role enabling such ambitious targets. SENSIBLE developed innovative features and functionalities based on energy storage and energy management. It was elected as an EU flagship innovation project for its innovation, excellence and ambitious targets of applying several use cases to three real world domains: i) distribution grids; ii) customers and iii) buildings. Grid domain developments were demonstrated in Évora as well as new energy services provision to end users, whilst the Nottingham demonstrator addressed the energy community domain. In Nuremberg, storage applications in the building domain were demonstrated. SENSIBLE's results show that energy storage applications are a key tool to enable the flexibility required for the energy transition and can provide benefits to the grid as well as the end user. The project's conclusions from the three domains, which are underpinned by the KPI results, prove the impact of energy storage on the energy system of the future.

Despite control efforts, Mycobacterium bovis incidence among cattle remains high in parts of England, Wales, and Northern Ireland, attracting political and public health interest in potential spread from animals to humans. To determine incidence among humans and to identify associated factors, we conducted a retrospective cohort analysis of human M. bovis cases in England, Wales, and Northern Ireland during 2002-2014. We identified 357 cases and observed increased annual case numbers (from 17 to 35) and rates. Most patients were >65 years of age and born in the United Kingdom. The median age of UK-born patients decreased over time. For 74% of patients, exposure to risk factors accounting for M. bovis acquisition, most frequently consumption of unpasteurized milk, was known. Despite the small increase in case numbers and reduction in patient age, M. bovis infection of humans in England, Wales, and Northern Ireland remains rare.