Sdvigi: Uzory prozy Nabokova by Zhuzha Kheteni
In: The Slavonic and East European review: SEER, Band 100, Heft 3, S. 543-544
ISSN: 2222-4327
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In: The Slavonic and East European review: SEER, Band 100, Heft 3, S. 543-544
ISSN: 2222-4327
In: The Slavonic and East European review: SEER, Band 99, Heft 1, S. 165-167
ISSN: 2222-4327
У статті розглянуто основні проблеми та причини міграційних процесів в Україні, наведено статистику основних показників міграції робочої сили в Україні. Автором зазначено основні напрями трудової міграції з України та охарактеризовано взаємозв`язок економічних та політичних процесів з міграцією робочої сили в Україні. Особливу увагу в статті приділено визначенню позитивних та негативних сторін міграції робочої сили та виокремлено вплив відтоку «інтелектуального» потенціалу. На основі проведеного дослідження визначено основні економічні наслідки міграційних процесів в Україні та зазначено їх вплив на соціально-економічні процеси в Україні. У статті запропоновані заходи щодо використання позитивних наслідків міграції на користь держави, що мають бути направлені на зміни в нормативно-правовому та мотивування громадян до інвестування коштів в національну економіку. ; The article deals with the main problems and causes of migration processes in Ukraine, provides statistics on the main indicators of labor migration in Ukraine. The author outlines the main directions of labor migration from Ukraine and describes the interconnection of economic and political processes with labor migration in Ukraine. Particular attention has paid in the article to determining the positive and negative aspects of the labor migration, and the influence of the outflow of "intellectual" potential has identified. Based on the conducted research, the main economic consequences of migration processes in Ukraine been outlined and their impact on socioeconomic processes in Ukraine is indicated. The article proposes measures on the use of positive effects of migration in favor of the state, which should been directed to changes in the normative and legal motivation of citizens to invest in the national economy.
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Актуальность данной статьи не вызывает сомнения, поскольку государственно-правовое регулирование производства и продажи алкоголя в современной России является непоследовательным, бессистемным, фрагментарным и неэффективным. Автор рассматривает исторический аспект с целью объяснения этой проблемы и высказывает свои суждения о необходимости преобразования государственно-правового регулирования в сфере производства и продажи алкоголя в России. В статье рассматривается четыре этапа государственно-правового регулирования производства и продажи алкоголя в России. Каждый этап отличается от другого формой государственного регулирования и нормативно-правовым содержанием. Спецификой государственно-правового регулирования в сфере производства и продажи алкоголя в России является отсутствие преемственности единого курса в этой области. Реформирование отрасли производства и продажи алкоголя всегда зависело от интереса узкого круга людей и не учитывало интересов личности, общества и государства. При смене власти менялся прежде выбранный курс государственно-правового регулирования производства и продажи алкоголя. Цикличность реформирования и порождаемая ею нестабильность отрасли производства и продажи алкоголя приводили к коррупции и пьянству. В статье подчеркивается необходимость комплексного, преемственного, согласованного и последовательного государственно-правового регулирования производства и продажи алкоголя в России. ; The importance of the issue under consideration is beyond doubt today, because in modern Russia the public legal control of alcohol production and sale is inconsistent, irregular, fragmentary and inefficient. The author considers the historical aspect to explain the problem and presents some ideas on necessity of reforming the public legal control of alcohol production and sale in Russia. The article focuses on four stages of public legal control of alcohol production and sale in Russia. Each stage differs in form of the government control and regulatory content. One of the specific features of public legal control of alcohol production and sale in Russia is the lack of continuity of uniform social and political course in this area. Reforms of alcohol production and sale always depended on the interests of a narrow circle of people and did not take into account the interests of individuals, society and the state. When the political regime changed, the course of public legal control of alcohol production and sale changed also. Cyclical nature of reforms and instability in the industry and sales of alcohol resulting from it led to corruption and heavy drinking. The article underlines the necessity of comprehensive, successive, coherent and consistent state-legal control of alcohol production and sale in Russia.
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In: Bulletin of Taras Shevchenko National University of Kyiv. Series: Biology, Band 80, Heft 1, S. 50-56
ISSN: 2308-8036
Overweight and obesity often cause some comorbidity like insulin resistance, diabetes type 2, cancer, cardio-vascular pathology etc. Pancreas is the important organ in carbohydrate metabolism and insulin signaling, that under obesity conditions undergo pathologic changes. For diminish adverse effects of obesity in the role of therapeutic agent is considered melatonin – pineal gland pleiotropic multifunctional molecule. In view of development precision medicine, which include processing personalized data of whole genome sequencing, microbiome, individual day/night regime etc., time selection of drug administration for maximize efficacy and minimize side effects to each patient in according of private organism circadian rhythm is the main goal of chronotherapy approach. The aim of our study was to determine morpho-functional state (morphology characteristic of exocrine and endocrine part; morphometric parameters: areas of pancreatic islets, acini and acinar cell nucleus) of pancreas in rats with high-calorie (high fat) diet-induced obesity after melatonin administration in determined time of the day (evening and morning). Melatonin was administered daily by gavage for 7 weeks in dose 30 mg/kg 1 h before lights-off (ZT11, evening) or 1 h after lights-on (ZT01, morning) rats with high-calorie diet (HCD). Rats with HCD had morbid changes in pancreas cells morphology of exocrine and endocrine part, which manifested in presence of macrophage and leukocyte infiltration of islets, vacuolization and lipid droplets in acinocytes cytoplasm, while areas of islets, acini and acinar cell nucleus decreased. Obese rats with melatonin administration demonstrate amelioration of HCD-associated changes in pancreas. Namely, in rats with development obesity melatonin administrations increased area of pancreatic islets in comparison to HCD group, moreover pancreas acini area reach control values. Also were observed difference between time-of-day interventions of melatonin on acinar cell nucleus area parameters: evening administration showed more strong action in increased to control level direction. Together, is suggesting about melatonin ameliorative role on morpho-functional state of pancreas exocrine and endocrine part under HCD-induced obesity conditions, additionally evening administration 1 h before light-off displayed more beneficial influence compared to morning.
For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types.
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