AIMS/OBJECTIVES: The aim of this study was to evaluate the hemostatic consequences of whole blood leukoreduction (LR). BACKGROUND: Whole blood is being used for trauma resuscitation in the military, and an increasing number of civilian trauma centres across the nation. The benefits of LR, such as decreased infectious and transfusion-related complications, are well established, but the effects on hemostatic parameters remain a concern. METHODS: Twenty-four units of whole blood were assigned to one of the four groups: non-leukoreduced (NLR), leukoreduced at 1 h and a height of 33 in. (LR-1), leukoreduced at 4 h and a height of 33 in. (LR-4(33)), or leukoreduced at 4 h and a height of 28 in. (LR-4(28)). Viscoelastic parameters, platelet aggregation, cell counts, physiological parameters and thrombin potential were evaluated immediately before and after LR, and on days 1, 7, 14 and 21 following LR. RESULTS: The viscoelastic parameters and thrombin generation potential were unchanged between the groups. Platelet aggregation was reduced in the LR-1 group compared with NLR after 7 days. The LR-4(28) group also showed a trend of reduced platelet aggregation compared with NLR. Aggregation in LR-4(33) was similar to NLR throughout the storage time. Physiological and electrolyte changes over the whole blood storage period were not affected by LR. CONCLUSION: Our study shows that whole blood can be LR at 4 h after collection and a height of 33 in. while maintaining platelet count and without altering platelet function and hemostatic performance.
Phase IV of BEMUSE Program is a necessary step for a subsequent uncertainty analysis. It includes the simulation of the reference scenario and a sensitivity study. The scenario is a LBLOCA and the reference plant is Zion 1 NPP, a 4 loop PWR unit. Thirteen participants coming from ten different countries have taken part in the exercise. The BEMUSE (Best Estimate Methods plus Uncertainty and Sensitivity Evaluation) Program has been promoted by the Working Group on Accident Management and Analysis (WGAMA) and endorsed by the Committee on the Safety of Nuclear Installations (CSNI). The paper presents the results of the calculations performed by participants and emphasizes its usefulness for future uncertainty evaluation, to be performed in next phase. The objectives of the activity are basically to simulate the LBLOCA reproducing the phenomena associated to the scenario and also to build a common, well-known, basis for the future comparison of uncertainty evaluation results among different methodologies and codes. The sensitivity calculations performed by participants are also presented. They allow studying the influence of different parameters such as material properties or initial and boundary conditions, upon the behaviour of the most relevant parameters related to the scenario.
Austrian Federal Ministry of Science, Research and Economy ; Austrian Science Fund ; Belgian Fonds de la Recherche Scientifique ; Fonds voor Wetenschappelijk Onderzoek ; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) ; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) ; Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) ; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) ; Bulgarian Ministry of Education and Science ; CERN ; Chinese Academy of Sciences ; Ministry of Science and Technology ; National Natural Science Foundation of China ; Colombian Funding Agency (COLCIENCIAS) ; Croatian Ministry of Science, Education and Sport ; Croatian Science Foundation ; Research Promotion Foundation, Cyprus ; Ministry of Education and Research, Estonia ; Estonian Research Council, Estonia ; European Regional Development Fund, Estonia ; Academy of Finland ; Finnish Ministry of Education and Culture ; Helsinki Institute of Physics ; Institut National de Physique Nucleaire et de Physique des Particules/CNRS, France ; Commissariat a l'Energie Atomique et aux Energies Alternatives/CEA, France ; Bundesministerium fur Bildung und Forschung, Germany ; Deutsche Forschungsgemeinschaft, Germany ; Helmholtz-Gemeinschaft Deutscher Forschungszentren, Germany ; General Secretariat for Research and Technology, Greece ; National Scientific Research Foundation, Hungary ; National Innovation Office, Hungary ; Department of Atomic Energy, India ; Department of Science and Technology, India ; Institute for Studies in Theoretical Physics and Mathematics, Iran ; Science Foundation, Ireland ; Istituto Nazionale di Fisica Nucleare, Italy ; Ministry of Science, ICT and Future Planning, Republic of Korea ; National Research Foundation (NRF), Republic of Korea ; Lithuanian Academy of Sciences ; Ministry of Education (Malaysia) ; University of Malaya (Malaysia) ; Mexican Funding Agency (CINVESTAV) ; Mexican Funding Agency (CONACYT) ; Mexican Funding Agency (SEP) ; Mexican Funding Agency (UASLP-FAI) ; Ministry of Business, Innovation and Employment, New Zealand ; Pakistan Atomic Energy Commission ; Ministry of Science and Higher Education, Poland ; National Science Centre, Poland ; Fundacao para a Ciencia e a Tecnologia, Portugal ; JINR, Dubna ; Ministry of Education and Science of the Russian Federation ; Federal Agency of Atomic Energy of the Russian Federation ; Russian Academy of Sciences ; Russian Foundation for Basic Research ; Ministry of Education, Science and Technological Development of Serbia ; Secretaria de Estado de Investigacion, Desarrollo e Innovacion, Spain ; Programa Consolider-Ingenio, Spain ; Swiss Funding Agency (ETH Board) ; Swiss Funding Agency (ETH Zurich) ; Swiss Funding Agency (PSI) ; Swiss Funding Agency (SNF) ; Swiss Funding Agency (UniZH) ; Swiss Funding Agency (Canton Zurich) ; Swiss Funding Agency (SER) ; Ministry of Science and Technology, Taipei ; Thailand Center of Excellence in Physics ; Institute for the Promotion of Teaching Science and Technology of Thailand ; Special Task Force for Activating Research ; National Science and Technology Development Agency of Thailand ; Scientific and Technical Research Council of Turkey ; Turkish Atomic Energy Authority ; National Academy of Sciences of Ukraine, Ukraine ; State Fund for Fundamental Researches, Ukraine ; Science and Technology Facilities Council, UK ; U.S. Department of Energy ; U.S. National Science Foundation ; Marie-Curie program ; European Research Council (European Union) ; EPLANET (European Union) ; Leventis Foundation ; A. P. Sloan Foundation ; Alexander von Humboldt Foundation ; Belgian Federal Science Policy Office ; Fonds pour la Formation a la Recherche dans l'Industrie et dans l'Agriculture (FRIA-Belgium) ; Agentschap voor Innovatie door Wetenschap en Technologie (IWT-Belgium) ; Ministry of Education, Youth and Sports (MEYS) of the Czech Republic ; Council of Science and Industrial Research, India ; HOMING PLUS program of the Foundation for Polish Science - European Union, Regional Development Fund ; OPUS program of the National Science Center (Poland) ; Compagnia di San Paolo (Torino) ; MIUR Project (Italy) ; Thalis program - EU-ESF ; Aristeia program - EU-ESF ; Greek NSRF ; National Priorities Research Program by Qatar National Research Fund ; Chulalongkorn University (Thailand) ; Chulalongkorn Academic into its 2nd Century Project Advancement Project (Thailand) ; Welch Foundation ; Science and Technology Facilities Council ; Estonian Research Council, Estonia: IUT23-4 ; Estonian Research Council, Estonia: IUT23-6 ; MIUR Project (Italy): 20108T4XTM ; Welch Foundation: C-1845 ; Science and Technology Facilities Council: ST/K003542/1 GRIDPP ; Science and Technology Facilities Council: ST/H000925/2 ; Science and Technology Facilities Council: ST/N001273/1 ; Science and Technology Facilities Council: ST/J005479/1 ; Science and Technology Facilities Council: ST/N000242/1 ; Science and Technology Facilities Council: ST/L005603/1 ; Science and Technology Facilities Council: ST/J004871/1 ; Science and Technology Facilities Council: GRIDPP ; Science and Technology Facilities Council: PP/E000479/1 ; Science and Technology Facilities Council: ST/K001639/1 CMS Upgrades ; Science and Technology Facilities Council: ST/H000925/1 ; Science and Technology Facilities Council: ST/J004901/1 ; Science and Technology Facilities Council: ST/I003622/1 ; Science and Technology Facilities Council: ST/M002020/1 ; Science and Technology Facilities Council: ST/L00609X/1 ; Science and Technology Facilities Council: ST/K001531/1 ; Science and Technology Facilities Council: ST/L00609X/1 GRIDPP ; Science and Technology Facilities Council: ST/I005912/1 ; Science and Technology Facilities Council: ST/I005912/1 GRIDPP ; Science and Technology Facilities Council: ST/K003844/1 GRIDPP ; Science and Technology Facilities Council: ST/J005665/1 ; Science and Technology Facilities Council: ST/K003224/1 CMS Upgrades ; Science and Technology Facilities Council: ST/M005356/1 ; Science and Technology Facilities Council: CMS ; Science and Technology Facilities Council: ST/K001256/1 ; Science and Technology Facilities Council: ST/K003542/1 GRID PP ; Science and Technology Facilities Council: ST/M005356/1 GRIDPP ; Science and Technology Facilities Council: PP/E002803/1 ; Science and Technology Facilities Council: ST/K003542/1 ; Science and Technology Facilities Council: ST/K001639/1 ; Science and Technology Facilities Council: ST/K003844/1 ; Science and Technology Facilities Council: ST/N000250/1 ; Science and Technology Facilities Council: ST/I000305/1 ; Science and Technology Facilities Council: ST/M004775/1 GRIDPP ; Science and Technology Facilities Council: ST/M004775/1 ; Science and Technology Facilities Council: ST/I003622/1 GRIDPP ; A search for supersymmetry in hadronic final states with highly boosted W bosons and b jets is presented, focusing on compressed scenarios. The search is performed using proton-proton collision data at a center-of-mass energy of 8 TeV, collected by the CMS experiment at the LHC, corresponding to an integrated luminosity of 19.7 fb(-1). Events containing candidates for hadronic decays of boosted W bosons are identified using jet substructure techniques, and are analyzed using the razor variables M-R and R-2, which characterize a possible signal as a peak on a smoothly falling background. The observed event yields in the signal regions are found to be consistent with the expected contributions from standard model processes, which are predicted using control samples in the data. The results are interpreted in terms of gluino-pair production followed by their exclusive decay into top squarks and top quarks. The analysis excludes gluino masses up to 1.1 TeV for light top squarks decaying solely to a charm quark and a neutralino, and up to 700 GeV for heavier top squarks decaying solely to a top quark and a neutralino.