Suchergebnisse

El Acuerdo sobre materias concretas para la mejora de la economíay el empleo de la Comunitat Valenciana 2021-2022 firmado por los sindicatosy la asociación empresarial más representativos en la comunidad autónoma imponela subrogación en todas las contratas públicas realizadas en el ámbito autonómico.El objeto de este artículo es comentar algunos puntos problemáticos delinteresante experimento negocial introducido en la Comunidad Valenciana, asícomo la experiencia de un año de su aplicación. Y es que el acuerdo puede servirde banco de pruebas de cara a posibles acuerdos similares en otros territorios,por lo que su análisis puede ser de provecho para juristas foráneos de la ComunidadValenciana. Sin embargo, la aplicación de este acuerdo está encontrando algunosobstáculos.
Valentziako Erkidegoko ekonomia eta enplegua hobetzeko gaizehatzei buruzko 2021-2022 Akordioak subrogazioa ezartzen du autonomia-eremuanegindako kontrata publiko guztietan. Autonomia-erkidegoan ordezkaritza handienaduten sindikatuek eta enpresa-elkarteak sinatu zuten akordioa. Artikulu honenxedea da Valentziako Erkidegoan egindako negozio-esperimentu interesgarri horrenalderdi gatazkatsu batzuk komentatzea, baita aplikatu eta urte beteko esperientziaere. Izan ere, akordioa proba-banku gisa erabil daiteke beste lurralde batzuetan ereantzeko akordioak lortzeko. Beraz, azterketa hori egitea probetxuzkoa izan daitekeValentziako Erkidegotik kanpoko juristentzat. Dena den, akordio horren aplikazioakbaditu oztopoak.
The Agreement on specific matters for the improvement of theeconomy and employment of the Valencian Community 2021-2022 signed bythe most representative unions and business association in the autonomous community imposes subrogation in all public contracts carried out in autonomousterritory. The purpose of this article is to comment on some problematic points ofthe interesting business experiment introduced in the Valencian community, aswell as the experience of one year of its application. And it is that the agreementcan serve as a test bed for possible similar agreements in other territories, soits analysis may be of interest to foreign jurists from the Valencian Community.However, the application of this agreement is encountering some obstacles.

Intro -- Preface -- Contents -- About the Editors -- PhyFire: An Online GIS-Integrated Wildfire Spread Simulation Tool Based on a Semiphysical Model -- 1 Introduction -- 2 PhyFire Model -- 2.1 Current PhyFire Model Equations -- 2.2 Numerical Method -- 2.3 Fire-Spotting Term -- 3 Online GIS Interface -- 3.1 Sinumcc Web Platform -- 3.2 Sinumcc GIS Server -- 4 Real Example -- 5 Conclusions -- References -- Physical Parametrisation of Fire-Spotting for Operational Wildfire Simulators -- 1 Introduction -- 2 Flame Geometry and Fire Intensity Interdependence -- 2.1 The Energy Conservation Principle for the Estimation of the Flame Height -- 2.2 Entrainment Estimation -- 2.3 Flame Geometry in the Unsteady Case -- 3 Application to the Firebrand Landing Distribution -- 4 Results and Discussions -- 5 Conclusions -- References -- Wind Shear Forecast in GCLP and GCTS Airports -- 1 Introduction -- 2 Data and Methods -- 2.1 Study Area -- 2.2 LLWS Conceptual Model -- 2.3 Data -- 2.4 Experimental Warning Systems -- 2.4.1 Headwind System -- 2.4.2 Percentile System -- 2.5 Systems Evaluation -- 3 Results -- 3.1 Verification -- 3.1.1 Discrete Verification -- 3.1.2 Continuous Verification -- 3.2 Study Case -- 4 Conclusions -- References -- One-Phase and Two-Phase Flow Simulation Using High-Order HDG and High-Order Diagonally Implicit Time Integration Schemes -- 1 Introduction -- 2 Numerical Model for One-Phase Flow -- 2.1 Continuous Model -- 2.2 HDG Spatial Discretization -- 2.3 Temporal Discretization -- 2.4 Non-linear Solver -- 2.5 Local Post-processing -- 3 Numerical Model for Two-Phase Flow -- 3.1 Continuous Model -- 3.2 HDG Spatial Discretization -- 3.3 Temporal Discretization -- 3.4 Non-linear Solver -- 3.5 Local Post-processing -- 4 Numerical Results -- 4.1 One-Phase Flow Through Homogeneous Material with an Obstacle.

The characterisation of the aerodynamic roughness length (z0) and the displacement height (d) is critical when modelling the wind field using the log vertical profile. It is known that the values of these parameters depend on land coverage and weather conditions. Thus, many authors have studied their relationship, providing typical values for each land cover. In this paper, we have performed a comprehensive literature review to collect the intervals of z0 and d values for each land coverage. Using these intervals, we estimate their values using an optimisation technique that improves the results of a downscaling wind model. The downscaling model is a 3D adaptive, mass-consistent finite element model (Wind3D) that takes values from the HARMONIE-AROME or ECMWF mesoscale numerical weather prediction models. The optimisation is carried out by a memetic algorithm that combines the Differential Evolution method, a rebirth operator and the L-BFGS-B algorithm. The fitness function to be minimised is the root mean square error (RMSE) against observed wind data. This fast procedure allows updating the aerodynamic parameters for any weather condition. Numerical experiments have been carried out to show the performance of the methodology. ; This work has been supported by the Spanish Government, "Secretaría de Estado de Investigación, Desarrollo e Innovación", "Ministerio de Economía y Competitividad", and FEDER, grant contract: CTM2014-55014-C3-1-R.

Triple-negative breast cancer (TNBC) lacks prognostic and predictive markers. Here, we use high-throughput phosphoproteomics to build a functional TNBC taxonomy. A cluster of 159 phosphosites is upregulated in relapsed cases of a training set (n = 34 patients), with 11 hyperactive kinases accounting for this phosphoprofile. A mass-spectrometry-to-immunohistochemistry translation step, assessing 2 independent validation sets, reveals 6 kinases with preserved independent prognostic value. The kinases split the validation set into two patterns: one without hyperactive kinases being associated with a >90% relapse-free rate, and the other one showing ≥1 hyperactive kinase and being associated with an up to 9.5-fold higher relapse risk. Each kinase pattern encompasses different mutational patterns, simplifying mutation-based taxonomy. Drug regimens designed based on these 6 kinases show promising antitumour activity in TNBC cell lines and patient-derived xenografts. In summary, the present study elucidates phosphosites and kinases implicated in TNBC and suggests a target-based clinical classification system for TNBC. ; We are grateful to the Spanish Biobanks integrated within the Spanish Network of National Biobanks for the tumor samples used in our investigations and to the Breast Cancer Group at VHIO for providing study materials. The present study was funded by FIS PI10/00288, FIS PI13/00430, and AECC Scientific Foundation "Beca de Retorno 2010"awarded to MQF; FIS PI11-00832, FIS PI14-00726, and ISCIII PIE15/00068 awarded to RC. I.Z. is a recipient of a La Caixa PhD Fellowship, 2011. S.F. is a recipient of a FPI grant (SEV-2015-0510-16-6). V.S. is supported by the Miguel Servet Program (CP14/00228). This work was also supported by the PRIME-XS project, Grant Agree- ment Number 262067, funded by the European Union Seventh Framework Program and the project Proteins At Work (project 184.032.201), a program of the Netherlands Proteomics Centre financed by the Netherlands Organisation for Scientific Research (NWO). ...