Suchergebnisse

Due to the particularities of SARS-CoV-2, public health policies have played a crucial role in the control of the COVID-19 pandemic. Epidemiological parameters for assessing the stage of the outbreak, such as the Effective Reproduction Number (R_t), are not always straightforward to calculate, raising barriers between the scientific community and non-scientific decision-making actors. The combination of estimators of R_t with elaborated Machine Learning-based forecasting techniques provides a way to support decision-making when assessing governmental plans of action. In this work, we develop forecast models applying logistic growth strategies and auto-regression techniques based on Auto-Regressive Integrated Moving Average (ARIMA) models for each country that records information about the COVID-19 outbreak. Using the forecast for the main variables of the outbreak, namely the number of infected (I), recovered (R), and dead (D) individuals, we provide a real-time estimation of R_t and its temporal evolution within a timeframe. With such models, we evaluate R_t trends at the continental and country levels, providing a clear picture of the effect governmental actions have had on the spread. We expect this methodology of combining forecast models for raw data to calculate R_t to serve as valuable input to support decision-making related to controlling the spread of SARS-CoV-2.

Due to the particularities of SARS-CoV-2, public health policies have played a crucial role in the control of the COVID-19 pandemic. Epidemiological parameters for assessing the stage of the outbreak, such as the Effective Reproduction Number (R-t), are not always straightforward to calculate, raising barriers between the scientific community and non-scientific decision-making actors. The combination of estimators ofR(t)with elaborated Machine Learning-based forecasting techniques provides a way to support decision-making when assessing governmental plans of action. In this work, we develop forecast models applying logistic growth strategies and auto-regression techniques based on Auto-Regressive Integrated Moving Average (ARIMA) models for each country that records information about the COVID-19 outbreak. Using the forecast for the main variables of the outbreak, namely the number of infected (I), recovered (R), and dead (D) individuals, we provide a real-time estimation ofR(t)and its temporal evolution within a timeframe. With such models, we evaluateR(t)trends at the continental and country levels, providing a clear picture of the effect governmental actions have had on the spread. We expect this methodology of combining forecast models for raw data to calculateR(t)to serve as valuable input to support decision-making related to controlling the spread of SARS-CoV-2. ; Centre for Biotechnology and Bioengineering-CeBiB (PIA project, Conicyt, Chile) FB0001 Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) 21181435

COVID-19 pandemic has reshaped our world in a timescale much shorter than what we can understand. Particularities of SARS-CoV-2, such as its persistence in surfaces and the lack of a curative treatment or vaccine against COVID-19, have pushed authorities to apply restrictive policies to control its spreading. As data drove most of the decisions made in this global contingency, their quality is a critical variable for decision-making actors, and therefore should be carefully curated. In this work, we analyze the sources of error in typically reported epidemiological variables and usual tests used for diagnosis, and their impact on our understanding of COVID-19 spreading dynamics. We address the existence of different delays in the report of new cases, induced by the incubation time of the virus and testing-diagnosis time gaps, and other error sources related to the sensitivity/specificity of the tests used to diagnose COVID-19. Using a statistically-based algorithm, we perform a temporal reclassification of cases to avoid delay-induced errors, building up new epidemiologic curves centered in the day where the contagion effectively occurred. We also statistically enhance the robustness behind the discharge/recovery clinical criteria in the absence of a direct test, which is typically the case of non-first world countries, where the limited testing capabilities are fully dedicated to the evaluation of new cases. Finally, we applied our methodology to assess the evolution of the pandemic in Chile through the Effective Reproduction Number R-t, identifying different moments in which data was misleading governmental actions. In doing so, we aim to raise public awareness of the need for proper data reporting and processing protocols for epidemiological modelling and predictions. ; Chilean National Agency for Research and development through ANID PIA Grant AFB180004 Centre for Biotechnology and Bioengineering - CeBiB (PIA project, Conicyt, Chile) FB0001 Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) 21181435