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CIB Publication 382: Selected papers presented at the CIB World Building Congres Construction and Society, Brisbane 5-9 May 2013 ; Papers from the Designated Session TG66 - Energy and the Built Environment ; There is an emerging consensus amongst governments, business sectors and civil societies regarding the urgent need to address the multiple challenges of climate change, environmental pollution, resource depletion and economic instability. The building and construction sector has been identified with the most opportunities for cost-effectively reducing carbon emissions. However, although business opportunities have been identified for low or zero carbon building (L/ZCB), L/ZCBs are generally perceived as more expensive and challenging than conventional buildings. Also, L/ZCBs are often addressed solely from their technological and environmental perspectives, while important economic and sociocultural aspects have been overlooked or examined implicitly. This paper aims to contribute to the knowledge of the challenges and opportunities of L/ZCB in a systems manner, and to explore how business models can help construction organisations address the former and maximise the latter. The research was carried out through the combination of a comprehensive literature review and case study with a large construction organisation which played a significant role in the UK and internationally. The examination of the challenges and opportunities employed the PESTEL analysis framework (Political, Economic, Sociocultural, Technological, Environmental and Legal). The case study included a desk study, observations, meetings and personal interviews with senior business and sustainability managers of the company. The results suggest the imperative role of business models for L/ZCB developments. Establishing and innovating business models were considered to present an opportunity for the company to sharpen their competitive edge in the market. A wide take-up of business models of L/ZCBs among construction firms was perceived to fit well the building industry's socio-technical system in addressing the multiple challenges. ; published_or_final_version

CIB Publication 382: Selected papers presented at the CIB World Building Congres Construction and Society, Brisbane 5-9 May 2013 ; Papers from the Designated Session TG66 - Energy and the Built Environment ; The implementation of sustainable technologies can improve the energy and carbon efficiency of existing retail buildings. However, the selection of an appropriate sustainable technology is a complex task due to the large number of technological alternatives and decision criteria that need to be considered. Also, there exist series of uncertainties that are associated with the use of sustainable technologies, but have to be evaluated to achieve realistic and transparent results. The selection of sustainable technology is therefore most challenging. An earlier study was conducted with UK experienced practitioners including clients/developers, engineers, contractors and suppliers to identify the drivers and barriers for the use of sustainable technologies in UK retail construction. One major barrier identified from the study was the lack of a decision making tool, highlighted by both construction professionals and stakeholders in the retail industry. The large number of alternatives and potential solutions require a decision support method to be implemented. Information data on the economic variables, energy performance and impact on the environment of these systems is presently affected by vagueness and lack of knowledge. To deal with this high level of complexity and uncertainty an evaluation support approach is needed. This paper aims to develop a decision making framework to assist both retailers and construction professionals to define and evaluate the selection of sustainable technological options for delivering retail buildings. The research was carried out through a combination of a critical literature review and a survey-based study using expert opinions of retailers and contractors. The developed framework of decision criteria should provide a sustainable technology model to assist both construction professionals and stakeholders in the retail industry to systematically and effectively select the most appropriate technology. This approach should make the decision progression more transparent and facilitate sustainable development of retail buildings in achieving the carbon targets set by the UK and other governments. ; published_or_final_version

Primary central nervous system phaeohyphomycosis is a fatal fungal infection due mainly to the neurotropic melanized fungiCladophialophora bantiana,Rhinocladiella mackenziei, andExophiala dermatitidis.Despite the combination of surgery with antifungal treatment, the prognosis continues to be poor, with mortality rates ranging from 50 to 70%. Therefore, a search for a more-appropriate therapeutic approach is urgently needed. Ourin vitrostudies showed that with the combination of amphotericin B and flucytosine against these species, the median fractional inhibitory concentration (FIC) indices for strains ranged from 0.25 to 0.38, indicating synergy. By use of Bliss independence analysis, a significant degree of synergy was confirmed for all strains, with the sum ΔE ranging from 90.2 to 698.61%. No antagonism was observed. These results indicate that amphotericin B, in combination with flucytosine, may have a role in the treatment of primary cerebral infections caused by melanized fungi belonging to the orderChaetothyriales Furtherin vivostudies and clinical investigations to elucidate and confirm these observations are warranted. ; Fil: Deng, S. First Hospital of Xinjiang Medical University; China. Second Military Medical University. Shanghai Institute of Medical Mycology; China ; Fil: Pan, W. Second Military Medical University. Shanghai Institute of Medical Mycology; China ; Fil: Liao, W. Second Military Medical University. Shanghai Institute of Medical Mycology; China ; Fil: de Hoog, G. S. CBS-KNAW Fungal Biodiversity Centre; Países Bajos. University of Amsterdam; Países Bajos. King Abdulaziz University; Arabia Saudita ; Fil: Gerrits van den Ende, A. H. G. CBS-KNAW Fungal Biodiversity Centre; Países Bajos. University of Amsterdam; Países Bajos ; Fil: Vitale, Roxana Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina ; Fil: Rafati, H. Erasmus University Medical Center; Países Bajos ; Fil: Ilkit, M. University of Çukurova; Turquía ; Fil: Van der Lee, A. H. Radboud University Medical Center; Países Bajos ; Fil: Rijs, A. J. M. M. Radboud University Medical Center; Países Bajos ; Fil: Verweij, P. E. Radboud University Medical Center; Países Bajos ; Fil: Seyedmousavi, S. Radboud University Medical Center; Países Bajos. Erasmus University Medical Center; Países Bajos. Mazandaran University of Medical Sciences; Irán

The airborne fungus Aspergillus fumigatus poses a serious health threat to humans by causing numerous invasive infections and a notable mortality in humans, especially in immunocompromised patients. Mould-active azoles are the frontline therapeutics employed to treat aspergillosis. The global emergence of azole-resistant A. fumigatus isolates in clinic and environment, however, notoriously limits the therapeutic options of mould-active antifungals and potentially can be attributed to a mortality rate reaching up to 100 %. Although specific mutations in CYP51A are the main cause of azole resistance, there is a new wave of azole-resistant isolates with wild-type CYP51A genotype challenging the efficacy of the current diagnostic tools. Therefore, applications of whole-genome sequencing are increasingly gaining popularity to overcome such challenges. Prominent echinocandin tolerance, as well as liver and kidney toxicity posed by amphotericin B, necessitate a continuous quest for novel antifungal drugs to combat emerging azole-resistant A. fumigatus isolates. Animal models and the tools used for genetic engineering require further refinement to facilitate a better understanding about the resistance mechanisms, virulence, and immune reactions orchestrated against A. fumigatus. This review paper comprehensively discusses the current clinical challenges caused by A. fumigatus and provides insights on how to address them. ; AA, RGR, and DSP were supported by NIH AI 109025. MH was supported by NIH UL1TR001442. AC was supported by the Fundação para a Ciência e a Tecnologia (FCT) (CEECIND/03628/2017 and PTDC/MED GEN/28778/2017). Additional support was provided by FCT (UIDB/50026/2020 and UIDP/50026/2020), the Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (ERDF) (NORTE-01-0145-FEDER-000013 and NORTE-01-0145-FEDER-000023), the European Union's Horizon 2020 Research and Innovation programme under grant agreement no. ...

A cable-driven parallel robot (CDPR) was developed for the installation of curtain wall modules (CWM). The research addressed the question of whether the CDPR was capable installing CWMs with sufficient accuracy while being competitive compared to conventional manual methods. In order to develop and test such a system, a conceptual framework that consisted of three sub-systems was defined. The tests, carried out in two close-to-real demonstration buildings, revealed an absolute accuracy of the CWM installation of 4 to 23 mm. The working time for installing a CWM was reduced to 0.51 h. The results also show that the system is competitive for a workspace greater than 96 m2 compared to conventional manual methods. However, improvements such as reducing the hours for setting up the CDPR on the one hand and achieving a faster and more robust MEE on the other hand will be still necessary in the future. ; This project has received funding from the European Union's Horizon 2020 research and innovation program under grant agreement No. 732513