Suchergebnisse

AbstractObjectiveWe investigated the implications of Korean mothers' tendency to gain self‐worth from their children's achievements (i.e., child‐based self‐worth) for child outcomes.BackgroundWe tested the role of psychological control in mediating the link between mothers' child‐based self‐worth and child outcomes. The moderating roles of contextual (i.e., school levels) and child characteristics (i.e., perceived maternal sacrifice) in this process were examined.MethodMothers and their children in elementary (n = 162) and in middle and high school (n = 172) were recruited. Mothers reported on their child‐based self‐worth and psychological control, and children reported on their perception of maternal sacrifice and their depression and hyperactivity.ResultsMothers' child‐based self‐worth predicted psychological control, which in turn, related to children's depression and hyperactivity. The link between maternal child‐based self‐worth and psychological control was stronger in the middle and high school sample. Children's perceived sacrifice attenuated the effects of psychological control on child outcomes.ConclusionMiddle and high school (vs. elementary) mothers with high child‐based self‐worth may be more vulnerable to exhibiting controlling parenting. The relationship between maternal child‐based self‐worth and child outcomes may vary by contextual and child characteristics.ImplicationsFindings denote the implications of parenting behaviors derived from parents' self‐concerns in child outcomes, as well as the role of children in parenting processes.

The phase I trial is the first step in administering a drug to humans, but it has no therapeutic purpose. Under the absence of therapeutic purpose, healthy volunteers demonstrated different motivations, unlike the actual patients participating in trials. There were many reported motivations, such as financial motivation, contributing to the health science, accessing ancillary health care benefits, scientific interest or interest in the goals of the study, meeting people, and general curiosity. The aim of this study was to identify the motivation and characteristics of healthy volunteers participating in phase I trials in the Republic of Korea. We gave surveys to 121 healthy volunteers to study their demographic characteristics and the reasons of participation. We identified whether the decision to participate in the research was influenced by demographic factors and whether the perception and attitudes toward the research were influenced by the characteristics of the healthy volunteers. After completion of the first survey, 12 healthy volunteers who had participated in a phase I clinical trial were selected to answer the second interview. According to our survey, most healthy volunteers were unmarried men and economically dependent. Most of them participated in the study because of financial reward. The most important factor to measure financial reward was the research period. Also, 43% of the volunteers were university students, 42% answered "university graduation" and 55% were residing in family-owned houses. Many healthy volunteers were found to be living in family homes and to have a student status or lack of economic independence. Results of the survey showed that 64% of respondents indicated having more than one clinical trial participation. In-depth interviews showed that healthy volunteers had diverse motivation to participate in research and that healthy volunteer perceive the clinical trial positively. The main motivation for healthy volunteers' participation in research was "financial reward." Healthy volunteers also considered research schedules, processes, and safety, and had a positive perception of clinical trials, but they thought that the public has a negative perception.

Abstract
In the brain, environmental changes, such as neuroinflammation, can induce senescence, characterized by the decreased proliferation of neurons and dendrites and synaptic and vascular damage, resulting in cognitive decline. Senescence promotes neuroinflammatory disorders by senescence-associated secretory phenotypes and reactive oxygen species. In human brain microvascular endothelial cells (HBMVECs), we demonstrate that chronological aging and irradiation increase death-associated protein kinase 3 (DAPK3) expression. To confirm the role of DAPK3 in HBMVEC senescence, we disrupted DAPK3 activity using small interfering RNA (siRNA) or a dominant-negative mutant (DAPK3-P216S), which reduced cellular senescence phenotypes, as assessed by changes in tube formation, senescence-associated beta-galactosidase activity, and cell proliferation. In endothelial cells, DAPK3 promotes cellular senescence by regulating the phosphorylation and inactivation of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC1α) via the protein kinase B pathway, resulting in the decreased expression of mitochondrial metabolism-associated genes, such as ATP5G1, BDNF, and COX5A. Our studies show that DAPK3 is involved in cellular senescence and PGC1α regulation, suggesting that DAPK3 regulation may be important for treating aging-related brain diseases or the response to radiation therapy.