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Energy efficiency has been widely recognised as a powerful tool for improving the energy situation across the globe. Whether by increasing energy security, reducing carbon emissions or alleviating grid strain, proven methods of energyefficiency management can bring about significant savings at a multitude of levels. Although energy-efficiency practices are gaining traction globally, their uptake is still less than optimal, and this is especially true of South Africa. The country is currently facing an energy crisis that brings with it a variety of complex challenges, all which can be assuaged through energy efficiency, if applied to the energy-intensive economy. It is important to understand the South Africa-specific barriers that hinder implementation of energy efficiency. While government has made strong commitments to supporting the uptake of energy-efficiency initiatives, there have been several interruptions and a lack of execution. An abundant amount of topdown research has been conducted to identify the various barriers to implementation; far less research, however, identifies barriers from within these energy-intensive economies. If these barriers could be identified from a more qualitative and participant-centred perspective, the key role-players in the sector might be able to better address energy-efficiency implementation, leading to more widespread benefits and results. To this end, the researcher performed an explanatory investigation, analysing seven energy-intensive companies that had recently participated in a fully funded local incentive scheme called the Private Sector Energy Efficiency Programme (PSEE). The PSEE performed an energy audit on each company, followed up by a report on its findings. The report clearly outlined the company's key energy-savings opportunities, in kilowatt-hours (kWh), Rand and CO2 emissions. It also estimated the costs and payback periods of the projects. Despite these reports indicating significant savings potentials and reasonable payback periods, a lack of uptake still remained. The researcher extracted and analysed the relevant quantitative data from the PSEE reports and conducted one-on-one, semi-structured interviews with the participants to identify and understand the participant-specific barriers to the recommended energy-efficient measures. The researcher also interviewed three coordinators of the PSEE programme, in the hope of identifying any PSEEspecific barriers. The other main party involved in this research was PSEE energy-efficiency ESCO which has been given an alias name ESCO E, who delivered the reports to the participants. The research found that the barriers in place in South Africa resemble those that have been identified at the global level. However, the mixed-methods approach and data sample employed in this study create a very interesting picture about the barriers that exist at the company level. The research found that there were significant saving opportunities available to companies but that, mainly due to a lack of financial support, human-resource capacity and time, there has been little to no implementation of the recommended projects. The available literature and provided global experience, coupled with participants' responses and suggestions, allow the researcher to make relevant recommendations that pertain to the study: • Lower payback periods through further incentives • Accessible funding and subsidies • Ensured continuation, longevity and growth of incentive programmes • Client-specific cost alternatives • Extensive and supported detail around each recommendation • Human resource capacity support to ensure energy management • Required energy seminars and skills training to programme participants • Increased government support and energy efficiency resources; namely an Energy Hub, which will provide a stable platform for energy efficiency • Participant-specific report alignment to encourage uptake and increased trust between incentive host and participant • More stringent government regulated technological standards.

AbstractThere is no relationship more vital than the one a child shares with their primary caregivers early in development. Yet many children worldwide are raised in settings that lack the warmth, connection, and stimulation provided by a responsive primary caregiver. In this study, we used data from the Bucharest Early Intervention Project (BEIP), a longitudinal study of institutionally‐reared and family‐reared children, to test how caregiving quality during infancy is associated with average EEG power over the first 3.5 years of life in alpha, beta, and theta frequency bands, and associations with later executive function (EF) at age 8 years. The sample comprised 189 children (129 institutionally‐reared; 60 family‐reared) who contributed data on observed caregiving quality during infancy (baseline; average age of 22 months), resting EEG power at baseline, 30, and 42 months, and performance‐based data on a series of EF tasks at 8 years. Using Bayesian estimation, observed caregiving quality at baseline was marginally linked with higher average alpha and beta power, and lower theta power, from baseline to 42 months. In turn, higher average beta power and lower average theta power were marginally associated with higher EF at 8 years. In indirect effects models, higher caregiving quality at baseline was associated with higher EF at 8 years, with a marginal indirect effect through average theta power from baseline to 42 months. Variation in the quality of the early caregiving environment may be associated with later executive function, which is partially underpinned by individual differences in brain activity during early childhood.Research Highlights
Examined associations between caregiving quality during infancy, brain activity during early childhood, and executive function during mid‐childhood in sample of never‐institutionalized and institutionally‐reared children.
Significant associations between higher quality caregiving during infancy and higher executive function during middle childhood.
Marginal associations between caregiving quality during infancy and brain activity during early childhood.
Marginal associations between brain activity during early childhood and executive function during mid‐childhood.

Isolated macrodactyly (OMIM 155500) belongs to a heterogeneous group of overgrowth syndromes. It is a congenital anomaly resulting in enlargement of all tissues localized to the terminal portions of a limb and caused by somatic mutations in the phosphatidylinositol 3-kinase catalytic alpha (PIK3CA, OMIM 171834) gene. Here we report a Hungarian girl with macrodactyly and syndactyly. Genetic screening at hotspots in the PIK3CA gene identified a mosaic mutation (c.1624G > A, p.Glu542Lys) in the affected tissue, but not in the peripheral blood. To date, this somatic mutation has been reported in eight patients affected by different forms of segmental overgrowth syndromes. Detailed analysis of the Hungarian child and previously reported cases suggests high phenotypic diversity associated with the p.Glu542Lys somatic mutation. The identification of the mutation provides a novel therapeutic modality for the affected patients: those who carry somatic mutations in the PIK3CA gene are potential recipients of a novel "repurposing" approach of rapamycin treatment. ; This research was supported by the European Union and the State of Hungary, co-financed by the European Social Fund in the framework of TÁMOP-4.2.4.A/ 2-11/1-2012-0001 "National Excellence Program." Nikoletta Nagy was also supported by the Hungarian Scientific Research Fund (OTKA) PD104782 grant. ; This is the author accepted manuscript. The final version is available from Elsevier via http://dx.doi.org/10.1016/j.ejmg.2016.02.002