Hilal Ahmed, Muslim Political Discourse in Postcolonial India: Monuments, Memory, Contestation
In: History and sociology of South Asia, Band 11, Heft 2, S. 226-229
ISSN: 2249-5312
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In: History and sociology of South Asia, Band 11, Heft 2, S. 226-229
ISSN: 2249-5312
In: Contemporary voice of Dalit, Band 9, Heft 1, S. 63-72
ISSN: 2456-0502
This article seeks to prepare an account of political activism of Dalits in Bihar during the years between 1913, when Dalits started to raise their voice through caste associations, and 1952, when the first election took place in Independent India. In between these years, there were various social campaigns, like the anti-untouchability campaign by a determined Congress under Gandhi, which faced stiff challenges from the orthodox sections of the caste-Hindu society. In the absence of a Dalit ideological campaign which was the case in some other parts of India under the inspiring leadership of Ambedkar, these efforts had a crucial role in raising Dalit issues, campaigning for the social rights of them and resisting the orthodox voices that were unwilling to respond favourably to these campaigns. The resistances of orthodox sections, however, failed to stop Dalit issues from being raised. This article argues that the Dalits of Bihar remained with Congress with high hopes till 1952. During this period, Dalit leaders from Bihar such as Jagjivan Ram and Jaglal Chaudhary had been trying to put pressure on the Congress leadership with (what they considered) legitimate and reasonable demands of Dalits. They believed that Congress represented the mainstream political space and that any development of Dalits could be possible only if along with attempts to raise the sense of unity among different Dalit castes, the efforts were made to impress upon the well-intentioned great national leaders of the country.
Phenformin's recently demonstrated efficacy in melanoma and Gleevec's demonstrated anti-proliferative action in chronic myeloid leukemia may lie within these drugs' significant pharmacokinetics, pharmacodynamics and structural homologies, which are reviewed herein. Gleevec's success in turning a fatal leukemia into a manageable chronic disease has been trumpeted in medical, economic, political and social circles because it is considered the first successful targeted therapy. Investments have been immense in omics analyses and while in some cases they greatly helped the management of patients, in others targeted therapies failed to achieve clinically stable recurrence-free disease course or to substantially extend survival. Nevertheless protein kinase controlling approaches have persisted despite early warnings that the targeted genomics narrative is overblown. Experimental and clinical observations with Phenformin suggest an alternative explanation for Gleevec's mode of action. Using 13C-guided precise flux measurements, a comparative multiple cell line study demonstrated the drug's downstream impact on submolecular fatty acid processing metabolic events that occurred independent of Gleevec's molecular target. Clinical observations that hyperlipidemia and diabetes are both reversed in mice and in patients taking Gleevec support the drugs' primary metabolic targets by biguanides and statins. This is evident by structural data demonstrating that Gleevec shows pyridine- and phenyl-guanidine homology with Phenformin and identical phenylcarbamoyl structural and ligand binding homology with Lipitor. The misunderstood mechanism of action of Gleevec is emblematic of the pervasive flawed reasoning that genomic analysis will lead to targeted, personalized diagnosis and therapy. The alternative perspective for Gleevec's mode of action may turn oncotargets towards metabolic channel reaction architectures in leukemia and melanoma, as well as in other cancers.
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