Suchergebnisse

For some years now, two intersex associations, Brújula Intersex and Stop Intersex Genital Mutilation, have been coordinating the participation in evaluation processes of the rights of intersex people convened by the United Nations. This article will try to analyse the legal strategies of these two associations to obtain the condemnation of several states by the United Nations. The ultimate goal is to draw a common thread of life stories, functioning of medical devices, silencing by governmental authorities, and possibilities for intersex people's agency.

For some years now, two intersex associations, Brújula Intersex and Stop Intersex Genital Mutilation, have been coordinating the participation in evaluation processes of the rights of intersex people convened by the United Nations. This article will try to analyse the legal strategies of these two associations to obtain the condemnation of several states by the United Nations. The ultimate goal is to draw a common thread of life stories, functioning of medical devices, silencing by governmental authorities, and possibilities for intersex people's agency.

Resumo Neste artigo analisamos a composição da força de trabalho na Europa e sua evolução, centrando-nos na relação entre precariedade, desemprego e segurança social, desde a crise de 1970 aos nossos dias, com particular atenção para as mudanças ocorridas depois da crise de 1970, da crise 1981-1984 e da crise de 2008. Centrar-nos-emos na composição da força de trabalho interna e externa (migrações) bem como nos efeitos a curto e médio prazo dos programas sociais focalizados e seu impacto na restruturação da força de trabalho, que veio colocar em causa o pacto social erguido na Europa do Norte e centro no pós guerra e na Europa do sul depois da revolução portuguesa e da transição espanhola nos anos 70 do século XX. As fontes deste trabalho são quantitativas (estatísticas da Comissão Europeia, análise de balanços sociais de empresa, Eurostat e INE) e qualitativas (pesquisa da evolução das políticas sindicais, entrevistas, entre outras).

It is important that academic research comes out into the open and communicates more and more with the outside world. Greater dissemination actions are increasingly urged by the European Union guidelines and university governance policies. This also in terms of the so-called "third mission", which joins the traditional purposes of teaching and research. The instrument of the testing laboratory, not so common in the architectural sector, can become a highly effective tool in this sense, if understood as an "open-lab" and therefore a "laboratory to be lived in". Even more if addressed to investigations for the enhancement of the historic assets, heritage of the community of citizens. The European HeLLo project (Horizon 2020, Marie Skłodowska-Curie IF programme) has moved into this direction, "opening the doors", in different ways, to public and private institutions, to the professional, to companies, as well as to the community in general. An in situ laboratory, in contact with "historic matter" and not in a distant and "aseptic" environment, analyses the real behaviour of insulating technologies for the efficiency of the building envelope. ; L'Ufficio Tecnico è una rivista scientifica dell'Area 08 (ANVUR - GEV 08), con Comitato scientifico. Testi in italiano con abtract in lingua inglese. L'articolo documenta alcuni risultati parziali del progetto europeo HeLLo (Horizon 2020, programma Marie Skłodowska-Curie IF), GA No 796712 (https://bit.ly/2ADCxks), nello specifico le azioni di disseminazione.

Genome-wide studies of African populations have the potential to reveal powerful insights into the evolution of our species, as these diverse populations have been exposed to intense selective pressures imposed by infectious diseases, diet, and environmental factors. Within Africa, the Sahel Belt extensively overlaps the geographical center of several endemic infections such as malaria, trypanosomiasis, meningitis, and hemorrhagic fevers. We screened 2.5 million single nucleotide polymorphisms in 161 individuals from 13 Sahelian populations, which together with published data cover Western, Central, and Eastern Sahel, and include both nomadic and sedentary groups. We confirmed the role of this Belt as a main corridor for human migrations across the continent. Strong admixture was observed in both Central and Eastern Sahelian populations, with North Africans and Near Eastern/Arabians, respectively, but it was inexistent in Western Sahelian populations. Genome-wide local ancestry inference in admixed Sahelian populations revealed several candidate regions that were significantly enriched for non-autochthonous haplotypes, and many showed to be under positive selection. The DARC gene region in Arabs and Nubians was enriched for African ancestry, whereas the RAB3GAP1/LCT/MCM6 region in Oromo, the TAS2R gene family in Fulani, and the ALMS1/NAT8 in Turkana and Samburu were enriched for non-African ancestry. Signals of positive selection varied in terms of geographic amplitude. Some genomic regions were selected across the Belt, the most striking example being the malaria-related DARC gene. Others were Western-specific (oxytocin, calcium, and heart pathways), Eastern-specific (lipid pathways), or even population-restricted (TAS2R genes in Fulani, which may reflect sexual selection). ; People Programme (Marie Curie Actions) of the European Union's Seventh Framework Programme FP7/2007-2013/ under REA grant agreement no. 290344 (EUROTAST). This project was also supported by the Grant Agency of the Czech Republic ...

This study was supported by the Fundação para a Ciência e a Tecnologia (PTDC/BEXBID/1411/ 2014 research grant). S.S. Lopes was funded by FCT Investigator IF/00951/2012, by NOVA Medical School and by FCT CEEC-IND 2018. P. Sampaio was funded by the PhD fellowship FCT: SFRH/BD/111611/2015. M. Roxo-Rosa was funded by the UID/Multi/04462/2013-LISBOA-01-0145-FEDER-007344 grant (iNOVA4Health). C.M. Quintão was funded by Fundação para a Ciência e Tecnologia (UID/FIS/04559/2013). S.S. Lopes participates in and acknowledge financial support from the COST Action BEAT-PCD (BM1407). S.S. Lopes received funding from project LysoCil funded by the European Union Horizon 2020 research and innovation under grant agreement No 811087. Funding information for this article has been deposited with the Crossref Funder Registry. ; Evaluation of ciliary beat frequency (CBF) performed by high-speed videomicroscopy analysis (HVMA) is one of the techniques required for the correct diagnosis of primary ciliary dyskinesia (PCD). Currently, due to lack of open-source software, this technique is widely performed by visually counting the ciliary beatings per a given time-window. Our aim was to generate open-source, fast and intuitive software for evaluating CBF, validated in Portuguese PCD patients and healthy volunteers. Nasal brushings collected from 17 adult healthy volunteers and 34 PCD-referred subjects were recorded using HVMA. Evaluation of CBF was compared by two different methodologies: the new semi-automated computer software CiliarMove and the manual observation method using slow-motion movies. Clinical history, nasal nitric oxide and transmission electron microscopy were performed for diagnosis of PCD in the patient group. Genetic analysis was performed in a subset (n=8) of suspected PCD patients. The correlation coefficient between the two methods was R-2=0.9895. The interval of CBF values obtained from the healthy control group (n=17) was 6.18-9.17 Hz at 25 degrees C. In the PCD-excluded group (n=16), CBF ranged from 6.84 to 10.93 ...

[EN] Background: Patients with cystic fibrosis (CF) and pancreatic insufficiency need pancreatic enzyme replacement therapy (PERT) for dietary lipids digestion. There is limited evidence for recommending the adequate PERT dose for every meal, and controlling steatorrhea remains a challenge. This study aimed to evaluate a new PERT dosing method supported by a self-management mobile-app. Methods: Children with CF recruited from 6 European centres were instructed to use the app, including an algorithm for optimal PERT dosing based on in vitro digestion studies for every type of food. At base-line, a 24h self-selected diet was registered in the app, and usual PERT doses were taken by the patient. After 1 month, the same diet was followed, but PERT doses were indicated by the app. Change in faecal fat and coefficient of fat absorption (CFA) were determined. Results: 58 patients (median age 8.1 years) participated. Baseline fat absorption was high: median CFA 96.9%, median 2.4g faecal fat). After intervention CFA did not significantly change, but range of PERT doses was reduced: interquartile ranges narrowing from 1447-3070 at baseline to 1783-2495 LU/g fat when using the app. Patients with a low baseline fat absorption (CFA 90%, n= 12) experienced significant improvement in CFA after adhering to the recommended PERT dose (from 86.3 to 94.0%, p=0.031). Conclusion: the use of a novel evidence-based PERT dosing method, based on in vitro fat digestion studies incorporating food characteristics, was effective in increasing CFA in patients with poor baseline fat absorption and could safely be implemented in clinical practice. ; We acknowledge the support of the MyCyFAPP Project consortium. We especially thank the participation and the effort of the patients involved in the study and their families. This work was fully funded by the European Union and the Horizon 2020 Research and Innovation Framework Programme (PHC-26-2014 call Self management of health and disease: citizen engagement and mHealth) under grant number ...

WOS: 000398562100001 ; PubMed ID: 28387361 ; Human mitochondrial DNA haplogroup U is among the initial maternal founders in Southwest Asia and Europe and one that best indicates matrilineal genetic continuity between late Pleistocene huntergatherer groups and present-day populations of Europe. While most haplogroup U subclades are older than 30 thousand years, the comparatively recent coalescence time of the extant variation of haplogroup U7 (-16-19 thousand years ago) suggests that its current distribution is the consequence of more recent dispersal events, despite its wide geographical range across Europe, the Near East and South Asia. Here we report 267 new U7 mitogenomes that -analysed alongside 100 published ones -enable us to discern at least two distinct temporal phases of dispersal, both of which most likely emanated from the Near East. The earlier one began prior to the Holocene (-11.5 thousand years ago) towards South Asia, while the later dispersal took place more recently towards Mediterranean Europe during the Neolithic (-8 thousand years ago). These findings imply that the carriers of haplogroup U7 spread to South Asia and Europe before the suggested Bronze Age expansion of Indo-European languages from the Pontic-Caspian Steppe region. ; Estonian Institutional Research grant [IUT24-1]; ERC Starting Investigator grant [FP7-261213]; EU European Regional Development Fund through the Centre of Excellence in Genomics to Estonian Biocentre; Estonian Research Council grant [PUT1339, PUT1217, PUT766]; University of Pavia strategic theme "Towards a governance model for international migration: an interdisciplinary and diachronic perspective" (MIGRAT-IN-G); Italian Ministry of Education, University and Research: Futuro in Ricerca [RBFR126B8I]; Progetti Ricerca Interesse Nazionale; Council of Scientific and Industrial Research, Government of India (GENESIS) [BSC0121, BSC 0118]; National geographic Society through Genographic Project Research Grant [6-13]; European Social Fund's Doctoral Studies and Internationalisation Programme DoRa; Leverhulme Trust's Doctoral Scholarship programme; University of Huddersfield's University Research Fund and Research Excellent Staff Scheme; FCT Investigator Programme [IF/01641/2013] ; We thank all the DNA donors who participated in this study. This study was supported by Estonian Institutional Research grant IUT24-1 (to H.S., E.M., M.R., M.M., T.K., and R.V.); ERC Starting Investigator grant (FP7-261213) (to T.K.); EU European Regional Development Fund through the Centre of Excellence in Genomics to Estonian Biocentre; Estonian Research Council grant PUT1339 (to A.K.), PUT1217 (to Kr.T.) and PUT766 (to G.C.); the University of Pavia strategic theme "Towards a governance model for international migration: an interdisciplinary and diachronic perspective" (MIGRAT-IN-G); the Italian Ministry of Education, University and Research: Futuro in Ricerca 2012 (RBFR126B8I) (to A.A. and A.O.) and Progetti Ricerca Interesse Nazionale 2012 (to A.A., O.S., and A.T.); the Council of Scientific and Industrial Research, Government of India (GENESIS: BSC0121) and (BSC 0118) (to Ku.T.); S.S. and E.R. acknowledge the support of National geographic Society through Genographic Project Research Grant (6-13). R.T. and A.K.P. were supported by the European Social Fund's Doctoral Studies and Internationalisation Programme DoRa. M.B.R. received support from the Leverhulme Trust's Doctoral Scholarship programme, and F.G. from the University of Huddersfield's University Research Fund and Research Excellent Staff Scheme. P.S. was supported by the FCT Investigator Programme (IF/01641/2013).