Suchergebnisse

Abstract

Background and purpose: This research aims to investigate which benefits one may expect using Maturity Models in Configuration Management (CM) domain. CM is a support process that helps organizations have better management of their infrastructure. Its importance, in the Information Technology (IT) domain, has increased in recent years, despite this process not being technologically new, and the fact that many organizations implement this process in a haphazard way, which results in it not producing the benefits that it should produce. With the intention of assessing and improving the organizations' IT processes practices and capabilities, MMs have been developed and implemented. However, the application of MM in the CM domain is yet to be explored.

Design/Methodology/Approach: Two Systematic Literature Reviews (SLRs) and a Critical Analysis were performed. In sum, 80 scientific articles of the most rated conferences and scientific journals were analyzed and conclusions were drawn.

Results: This research concludes that despite the CM process being badly implemented, using a MM this process could decrease operational costs and increase the quality management of the infrastructure.

Conclusion: However, no MM has been developed so far for the CM process practices. This MM would be a viable support tool for the IT organizations providers since this would help organizations have a mature CM process and better control of their IT infrastructure. Therefore, the existence of a MM for the CM domain would be a welcome advancement that should be developed in the future.

SIMPLE SUMMARY: Three-dimensional (3D) cell culture models have been proposed as alternatives for initial drug screening to increase drug development efficiency. In addition to their ability to reproduce key aspects of the tumor architecture and microenvironment, 3D cell culture models may help decrease the use of laboratory animals in drug testing, in accordance with the 3R principles (Replacement, Reduction, Refinement). This review aims to help researchers making a transition from two-dimensional (2D) to 3D cell culture models for drug screening, by discussing the impact of 3D models on cancer research, their advantages, limitations, and compatibility with high-throughput screenings. It also outlines the relevance of available readouts provided by such models as well as the importance of incorporating key microenvironmental cues towards improving the predictive value of drug efficacy and safety. ABSTRACT: Today, innovative three-dimensional (3D) cell culture models have been proposed as viable and biomimetic alternatives for initial drug screening, allowing the improvement of the efficiency of drug development. These models are gaining popularity, given their ability to reproduce key aspects of the tumor microenvironment, concerning the 3D tumor architecture as well as the interactions of tumor cells with the extracellular matrix and surrounding non-tumor cells. The development of accurate 3D models may become beneficial to decrease the use of laboratory animals in scientific research, in accordance with the European Union's regulation on the 3R rule (Replacement, Reduction, Refinement). This review focuses on the impact of 3D cell culture models on cancer research, discussing their advantages, limitations, and compatibility with high-throughput screenings and automated systems. An insight is also given on the adequacy of the available readouts for the interpretation of the data obtained from the 3D cell culture models. Importantly, we also emphasize the need for the incorporation of additional and ...