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Night as Frontier: Colonizing the World After Dark.Murray Melbin
In: The American journal of sociology, Band 95, Heft 4, S. 1089-1091
ISSN: 1537-5390
City Trenches: Urban Politics and the Patterning of Class in the United States.Ira Katznelson
In: The American journal of sociology, Band 88, Heft 4, S. 808-810
ISSN: 1537-5390
Administration reform in the operation of land registries [New Zealand]
In: The New Zealand journal of public administration, Band 26, S. 20-33
ISSN: 0028-8357, 0110-5000
Parent-Child Psychotherapy: A Follow-Up Study Comparing Two Techniques
In: The journal of psychology: interdisciplinary and applied, Band 49, Heft 2, S. 195-202
ISSN: 1940-1019
Contributions to a Learning Theory Account of Childhood Autism
In: The journal of psychology: interdisciplinary and applied, Band 43, Heft 1, S. 117-124
ISSN: 1940-1019
American participation in belligerent commercial controls, 1914-1917
In: American journal of international law, Band 27, S. 675-693
ISSN: 0002-9300
Abacavir and the altered peptide repertoire model: clinical implications
In: Journal of the International AIDS Society, Band 15, Heft S4, S. 1-1
ISSN: 1758-2652
Structural and biochemical studies showing that abacavir binds non‐covalently to the floor of the peptide binding groove of HLA‐B*5701 with exquisite specificity to alter the self‐peptides that load on the molecule to be presented to the immune system have recently been published 1–4. This precise mechanistic explanation of why abacavir binds to HLA‐B*5701 and no other allele accounts for the 100% negative predictive value of HLA‐B*5701 testing for hypersensitivity which underpins its utility as a screening test. The specificity of the interaction between abacavir, peptide and HLA‐B*5701 provides strong evidence that abacavir will not cause any off‐target, HLA restricted immune‐mediated side effects in HLA‐B*5701 negative individuals. The rapid and direct non‐covalent binding of abacavir to HLA‐B*5701 without the requirement for metabolism of the drug explain the clinical symptoms of hypersensitivity including dose‐related escalation of symptoms and rapid offset of symptoms following drug cessation. Importantly, if abacavir were being developed today its propensity to bind HLA‐B*5701, alter the peptide repertoire presented, and the functional consequences of this interaction between HLA‐B*5701 and abacavir could be determined in vitro and before use in man. This provides an important pre‐clinical screening strategy to identify compounds in development that bind HLA and alter peptide presentation which could then be structurally modified to abrogate this property to avert hypersensitivity while retaining on‐target effects.
Watch What We Say, Not What We Do?
In: Public administration review: PAR, Band 34, Heft 5, S. 517
ISSN: 1540-6210
The Mongols
In: Man: the journal of the Royal Anthropological Institute of Great Britain and Ireland, Band 4, Heft 3, S. 483
Interference vs Extinction as Learning Models for Psychotherapy
In: The journal of psychology: interdisciplinary and applied, Band 51, Heft 2, S. 399-403
ISSN: 1940-1019
The Modern History of Mongolia
In: Pacific affairs: an international review of Asia and the Pacific, Band 42, Heft 4, S. 521
ISSN: 1715-3379