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"This series has now established itself as the leading publication on the multi-disciplinary subject of tissue banking. The high quality of the contributors and the broad coverage of the subject have continued in Volume 4. The material given in this volume is not presented anywhere else as systematically or as authoritatively.The essential feature in establishing confidence in the quality and safety of allografts is the manufacturing quality system utilised. This volume describes the most recent approach to good manufacturing control.Throughout the world, the old cottage approach to tissue banking is being abandoned, mainly due to the insistence by regulatory authorities that the procedures should be standardised and rigorous infection control applied. The experience in a number of countries is described in this volume, giving the reader quick access to developments in Argentina, Finland, Indonesia, Scotland and France. These represent a geographical and cultural spread of the developments.A balance needs to be struck between the use of allografts and of bone substitutes, depending on the clinical condition and the availability of grafts in a particular situation. The subject areas — such as mandibular reconstruction, spinal surgery, surgery and reconstruction of bone tumours and acetabular revision — covered in this volume demonstrate the universality of this technique. The use of allografts for the repair of knee ligaments has been and remains a controversial subject. The contributions on this subject will surely be an important and positive addition to this debate."

Advances in Tissue Banking is the first authoritative publication to encompass this interdisciplinary field, which is now providing hundreds of thousands of tissue grafts for transplant surgery every year worldwide (400,000 grafts in the USA alone annually). There is no text book which can be consulted about the subject, since the field has moved so rapidly over the past few years. The scientific and medical publications are scattered throughout specialised literature and are not readily accessible to all the diverse practitioners. This book, volume 1 of the new series, is written by experts on the subject. It is designed to fill the gap and provide a vehicle of communication for those participating in various aspects of the subject. Regulators are still in the process of coming to grips with the requirements to ensure safety and find a suitable definition within the legislative system for a "transplant tissue". The various transplant donation systems in various countries differ. Allografts are used extensively in orthopaedic surgery, burns and wound healing. Heart valve banking has now established itself. Central to the subject is the prevention of the transmission of infection, with great emphasis being placed on the screening of donors, preservation and sterilisation of the tissues using the best and safest procedures. Nobody connected with regulating, producing, or using tissues can afford to be without the concentrated information so readily provided in this book, which is not available elsewhere. It will also be of great value to scientists and doctors who wish to learn about the subject and to introduce it into general scientific and medical education

Advances in Tissue Banking is the only series of publications where producers and clinical users of tissues can learn in one place about developments in this interdisciplinary field. This important volume concentrates on the new leading topics, and bridges the tissue banking technology and the scientific developments, which fuel this rapidly growing field. It presents the regulatory controls being introduced in the USA, Europe and Japan, as well as the relationship among technical orthopaedics, in vitro tissue engineering, and osteoinduction. New subject areas in the volume include cell processing and preservation, particularly for islet and stem cells; preservation, processing and viability of vascular grafts; and gland transplantation. Collagen biochemistry is reviewed and linked to skin substitutes and skin banking. The volume fully reflects present global developments, with contributions from Spain, Japan, Russia, Poland, Estonia and the USA, among other countries

List of contributors -- Preface -- Section I. The contribution of the International Atomic Energy Agency (IAEA) to tissue banking. ch. 1. The International Atomic Energy Agency (IAEA) Programme in Radiation and Tissue Banking: past and present. ch. 2. IAEA public awareness strategies for tissue banks -- Section II. Safety of tissue allografts. ch. 3. Infectious disease transmission through tissue transplantation. ch. 4. Bacterial contamination of bone allografts in the Netherlands. ch. 5. Microbiological screening of cadaver donors and tissues for transplantation. ch. 6. Safety of virus inactivation methods for allogeneic avital bone tissue transplants. ch. 7. Methods of culturing, problems associated with bacteriostasis, and radiation sterilisation options. ch. 8. IAEA Code of Practice for the radiation sterilisation of tissue allografts: requirements for validation and routine control. ch. 9. IAEA international standards for tissue banks. ch. 10. In Vivo assessment of gamma irradiated bone: osteoconductivity and osteoinductivity. ch. 11. Disinfection of femoral heads for bone grafting using the Marburg bone bank system (Lobator Sd 1) - a retrospective evaluation of quality control in the Endo-Klinik Bone Bank -- Section III. Ethical and social aspects of tissue banking. ch. 12. Tissue banking and transplantation: the ethical challenges. ch. 13. The Volendam burn disaster and the importance of international collaboration in tissue banking. ch. 14. The need for a tissue bank in a disaster: experience in Arzobispo Loayza National Hospital after the tragedy in "Mesa Redonda", Lima, Peru -- Section IV. Tissue grafts in orthopaedics. ch. 15. Major limb reconstruction using massive cadaveric allografts. ch. 16. Revision arthroplasty using fresh frozen allograft with cemented cup for acetabular bone deficiency. ch. 17. Present ways of treating chondral and osteochondral knee defects. ch. 18. Knee joint ligament alloplasty with tendon grafts sterilised with gaseous ethylene oxide. ch. 19. New approaches to comparative evaluation of allogenic and autologous bone transplants procured in various ways.