Suchergebnisse

ObjectiveValidating objective, brain-based indices of consciousness in behaviorally unresponsive patients represents a challenge due to the impossibility of obtaining independent evidence through subjective reports. Here we address this problem by first validating a promising metric of consciousnessthe Perturbational Complexity Index (PCI)in a benchmark population who could confirm the presence or absence of consciousness through subjective reports, and then applying the same index to patients with disorders of consciousness (DOCs). MethodsThe benchmark population encompassed 150 healthy controls and communicative brain-injured subjects in various states of conscious wakefulness, disconnected consciousness, and unconsciousness. Receiver operating characteristic curve analysis was performed to define an optimal cutoff for discriminating between the conscious and unconscious conditions. This cutoff was then applied to a cohort of noncommunicative DOC patients (38 in a minimally conscious state [MCS] and 43 in a vegetative state [VS]). ResultsWe found an empirical cutoff that discriminated with 100% sensitivity and specificity between the conscious and the unconscious conditions in the benchmark population. This cutoff resulted in a sensitivity of 94.7% in detecting MCS and allowed the identification of a number of unresponsive VS patients (9 of 43) with high values of PCI, overlapping with the distribution of the benchmark conscious condition. InterpretationGiven its high sensitivity and specificity in the benchmark and MCS population, PCI offers a reliable, independently validated stratification of unresponsive patients that has important physiopathological and therapeutic implications. In particular, the high-PCI subgroup of VS patients may retain a capacity for consciousness that is not expressed in behavior. Ann Neurol 2016;80:718-729 ; Prin "Connage" (Italian Government) ; European Union (EU) ; James S. McDonnell Foundation Scholar Award ; Belgian National Fund for Scientific Research ; Templeton World Charity Foundation ; McDonnell Foundation ; Distinguished Chair in Consciousness Science at the University of Wisconsin ; Univ Milan, Dept Biomed & Clin Sci L Sacco, Via GB Grassi 74, I-20157 Milan, Italy ; Fdn Europea Ric Biomed, Milan, Italy ; Univ Milano Bicocca, Sch Med & Surg, Dept Hlth Sci, Monza, Italy ; Univ Fed Sao Paulo, Inst Sci & Technol, Sao Jose Dos Campos, Brazil ; Fdn Don Gnocchi Onlus, Ist Ricovero & Cura Carattere Sci, Milan, Italy ; Univ Wisconsin, Dept Psychiat, Madison, WI 53706 USA ; Univ Wisconsin, Dept Neurol, Madison, WI 53706 USA ; Univ Liege, Coma Sci Grp, GIGA, Liege, Belgium ; Univ Liege, Dept Neurol, Liege, Belgium ; Univ Hosp Liege, Liege, Belgium ; Grande Osped Metropolitano Niguarda Ca Granda, Neurocrit Care Unit, Azienda Sociosanit Terr, Dept Neurosci, Milan, Italy ; Institute of Science and Technology, Universidade Federal de São Paulo (UNIFESP), São José dos Campos, Brazil ; EU: 600806 ; EU: 686764 ; EU: 720270 ; Web of Science