In: The European journal of development research: journal of the European Association of Development Research and Training Institutes (EADI), Band 12, Heft 2, S. 72-92
This study examines changing expressions of masculinity and gender relations of power in Colombian women-headed households in which men are working, and women have access to micro credit linked to the financial NGO Women's World Banking. The study describes the labour market context within which the dynamics of gender relations between couples have taken place. (DSE/DÜI)
A sound suppressor is an internal or external device coupled to the barrel of a firearm. Its development has been historically related to the negative effects produced by the noise. This article presents the numerical and experimental analysis of a sound suppressor for a 5.56 mm caliber rifle. It was designed, manufactured, and tested inside a shooting tunnel for 911 m/s and 344 m/s velocities. Three geometric configurations with curved deflectors, conical deflectors, and finally with a reactive spiral capable of dissipating the acoustic wave were compared considering reactive and dissipative systems. The attenuation of the sound inside the silencer depends directly on the reduction of the projectile wave velocity and the deflagration of the gases at the instant of firing. Then the MIL-STD-1474E standard was used to carry out the experiments. The results in the computational numerical simulation show an average value of 143 dB for the considered three models, the Sound Pressure Level in the reactive core model decreased by 25% with respect to other proposals, which have an average value of 141 dB. These results can be useful to improve in the design of sound suppressors based on the needs of the users and under the specific characteristics of each weapon ballistic.
There is little evidence assessing compliance with clinical practice guidelines for antiretroviral treatment and its impact on clinical outcomes. The Spanish national guidelines for antiretroviral treatment are published by the Spanish AIDS Study Group (GeSIDA). The aim of this study was to assess compliance with national guidelines for the treatment of naïve patients from a multicentre Spanish cohort (CoRIS). The specific aims were to evaluate the proportion of patients treated according to the guidelines' recommendations, to investigate factors associated with the prescription of a non‐recommended treatment, and to assess the impact of non‐recommended treatments on mortality and on virological and immunological response (defined as undetectable viral load and increase of 100 CD4/ml, respectively, after 1 year). Drug combinations were classified as recommended, alternative, or not recommended, according to the guidelines' "what to start with" recommendations. 6225 naïve patients were included between the years 2004 and 2010. Among 4516 patients who started treatment, 3592 (79.5%), 540 (12%), and 384 (8.5%) started with a recommended, alternative and not‐recommended treatment, respectively. The use of a not‐recommended treatment was significantly associated with CD4 count >500/ml (OR: 2.03, 95% CI: 1.14–3.59), hepatitis B infection (OR: 2.23, 95% CI: 1.50–3.33), treatment in a hospital with <500 beds, and starting treatment in the years 2004 to 2006. There was no significant association of having a not‐recommended treatment with gender, route of transmission, hepatitis C infection, country of origin, education, or viral load. The use of a not‐recommended regimen was significantly associated with mortality (HR: 1.61, 95% CI: 1.03–2.52, p=0.035) and lack of virological response (OR: 0.65, 95% CI: 0.45–0.93, p=0.019), but it was not associated with immunological response (OR: 0.90, 95% CI: 0.75–1.08, p=0.273). In conclusion, compliance with "what to start with" recommendations of Spanish national guidelines was high. The use of not‐recommended regimens was more likely in patients with >500 CD4/ml, hepatitis B infection, and starting treatment in the years 2004–2006 and in small hospitals. Not‐recommended regimens were associated with higher mortality and lack of virological response.
21 pags., 16 figs., 7 tabs., 2 apps. ; Context. Sulphur is one of the most abundant elements in the Universe. Surprisingly, sulphuretted molecules are not as abundant as expected in the interstellar medium and the identity of the main sulphur reservoir is still an open question. Aims. Our goal is to investigate the H2S chemistry in dark clouds, as this stable molecule is a potential sulphur reservoir. Methods. Using millimeter observations of CS, SO, H2S, and their isotopologues, we determine the physical conditions and H2S abundances along the cores TMC 1-C, TMC 1-CP, and Barnard 1b. The gas-grain model NAUTILUS is used to model the sulphur chemistry and explore the impact of photo-desorption and chemical desorption on the H2S abundance. Results. Our modeling shows that chemical desorption is the main source of gas-phase H2S in dark cores. The measured H2S abundance can only be fitted if we assume that the chemical desorption rate decreases by more than a factor of 10 when nH > 2 × 104. This change in the desorption rate is consistent with the formation of thick H2O and CO ice mantles on grain surfaces. The observed SO and H2S abundances are in good agreement with our predictions adopting an undepleted value of the sulphur abundance. However, the CS abundance is overestimated by a factor of 5-10. Along the three cores, atomic S is predicted to be the main sulphur reservoir. Conclusions. The gaseous H2S abundance is well reproduced, assuming undepleted sulphur abundance and chemical desorption as the main source of H2S. The behavior of the observed H2S abundance suggests a changing desorption efficiency, which would probe the snowline in these cold cores. Our model, however, highly overestimates the observed gas-phase CS abundance. Given the uncertainty in the sulphur chemistry, we can only conclude that our data are consistent with a cosmic elemental S abundance with an uncertainty of a factor of 10. ; We thank the Spanish MINECO for funding support from AYA2016-75066-C2-1/2-P, AYA2017-85111P, and ERC under ERC-2013-SyG, G. A. 610256 NANOCOSMOS. JM acknowledges the support of ERC-2015-STG No. 679852 RADFEEDBACK. S.P.T.M. acknowledge to the European Union's Horizon 2020 research and innovation program for funding support given under grant agreement No 639459 (PROMISE).
26 pags., 7 figs., 2 tabs., 2 apps. ; GEMS is an IRAM 30 m Large Program whose aim is determining the elemental depletions and the ionization fraction in a set of prototypical star-forming regions. This paper presents the first results from the prototypical dark cloud Taurus molecular cloud (TMC) 1. Extensive millimeter observations have been carried out with the IRAM 30 m telescope (3 and 2 mm) and the 40 m Yebes telescope (1.3 cm and 7 mm) to determine the fractional abundances of CO, HCO, HCN, CS, SO, HCS, and N H in three cuts which intersect the dense filament at the well-known positions TMC 1-CP, TMC 1-NH3, and TMC 1-C, covering a visual extinction range from A ~ 3 to ~20 mag. Two phases with differentiated chemistry can be distinguished: (i) the translucent envelope with molecular hydrogen densities of 1-5 × 10 cm; and (ii) the dense phase, located at A > 10 mag, with molecular hydrogen densities >10 cm. Observations and modeling show that the gas phase abundances of C and O progressively decrease along the C/C/CO transition zone (A~ 3 mag) where C/H ~ 8 × 10 and C/O ~ 0.8-1, until the beginning of the dense phase at A ~ 10 mag. This is consistent with the grain temperatures being below the CO evaporation temperature in this region. In the case of sulfur, a strong depletion should occur before the translucent phase where we estimate an S/ H ~ (0.4-2.2) × 10, an abundance ~7-40 times lower than the solar value. A second strong depletion must be present during the formation of the thick icy mantles to achieve the values of S/H measured in the dense cold cores (S H ~ 8 × 10) . Based on our chemical modeling, we constrain the value of ζ to ~(0.5-1.8) × 10 s in the translucent cloud. ; We thank the Spanish MINECO for funding support from AYA2016-75066-C2-1/2-P, and the ERC under ERC-2013-SyG, G. A. 610256 NANOCOSMOS. JM acknowledges the support of ERC-2015-STG No. 679852 RADFEEDBACK. SPTM acknowledges to the European Union's Horizon 2020 research and innovation program for funding support given under grant agreement No 639459 (PROMISE). RMD acknowledges support provided by an award from the Simons Foundation (SCOL#321183, KO). GMC acknowedges funding support fromAYA2017-85322-R. MT acknowledges partial support from project AYA2016-79006-P." ; Peer Reviewed
Aims. The Seeds Of Life In Space IRAM/NOEMA large program aims at studying a set of crucial complex organic molecules in a sample of sources with a well-known physical structure that covers the various phases of solar-type star formation. One representative object of the transition from the prestellar core to the protostar phases has been observed toward the very low luminosity object (VeLLO) L1521F. This type of source is important to study to link prestellar cores and Class 0 sources and also to constrain the chemical evolution during the process of star formation. Methods. Two frequency windows (81.6-82.6 GHz and 96.65-97.65 GHz) were used to observe the emission from several complex organics toward the L1521F VeLLO. These setups cover transitions of ketene (HCCO), propyne (CHCCH), formamide (NHCHO), methoxy (CHO), methanol (CHOH), dimethyl ether (CHOCH), and methyl formate (HCOOCH). Results. Only two transitions of methanol (A, E) have been detected in the narrow window centered at 96.7 GHz (with an upper limit on E) in a very compact emission blob (∼7″ corresponding to ∼1000 au) toward the northeast of the L1521F protostar. The CS 2-1 transition is also detected within theWideX bandwidth. Consistently with what has been found in prestellar cores, the methanol emission appears ∼1000 au away from the dust peak. The location of the methanol blob coincides with one of the filaments that have previously been reported in the literature. The excitation temperature of the gas inferred from methanol is (10 ± 2) K, while the H gas density (estimated from the detected CS 2-1 emission and previous CS 5-4 ALMA observations) is a factor >25 higher than the density in the surrounding environment (n(H) ≥ 10 cm). Conclusions. Based on its compactness, low excitation temperature, and high gas density, we suggest that the methanol emission detected with NOEMA is (i) either a cold and dense shock-induced blob that formed recently (≤ a few hundred years) by infalling gas or (ii) a cold and dense fragment that may just have been formed as a result of the intense gas dynamics within the L1521F VeLLO system. ; With funding from the Spanish government through the "María de Maeztu Unit of Excellence" accreditation (MDM-2017-0737)
16 páginas, 5 figuras ; Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer's disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer's disease patients in APOE ɛ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer's disease. ; The present work has been performed as part of the doctoral program of I. de Rojas at the Universitat de Barcelona (Barcelona, Spain) supported by national grant from the Instituto de Salud Carlos III FI20/00215. The Genome Research @ Fundació ACE project (GR@ACE) is supported by Grifols SA, Fundación bancaria "La Caixa", Fundació ACE, and CIBERNED. A.R. and M.B. receive support from the European Union/EFPIA Innovative Medicines Initiative Joint undertaking ADAPTED and MOPEAD projects (grant numbers 115975 and 115985, respectively). M.B. and A.R. are also supported by national grants PI13/02434, PI16/01861, PI17/01474, PI19/01240 and PI19/01301. Acción Estratégica en Salud is integrated into the Spanish National R + D + I Plan and funded by ISCIII (Instituto de Salud Carlos III)—Subdirección General de Evaluación and the Fondo Europeo de Desarrollo Regional (FEDER—"Una manera de hacer Europa"). Some control samples and data from patients included in this study were provided in part by the National DNA Bank Carlos III (www.bancoadn.org, University of Salamanca, Spain) and Hospital Universitario Virgen de Valme (Sevilla, Spain); they were processed following standard operating procedures with the appropriate approval of the Ethical and Scientific Committee. Amsterdam dementia Cohort (ADC): Research of the Alzheimer center Amsterdam is part of the neurodegeneration research program of Amsterdam Neuroscience. The Alzheimer Center Amsterdam is supported by Stichting Alzheimer Nederland and Stichting VUmc fonds. The clinical database structure was developed with funding from Stichting Dioraphte. Genotyping of the Dutch case-control samples was performed in the context of EADB (European Alzheimer DNA biobank) funded by the JPco-fuND FP-829-029 (ZonMW project number 733051061). 100-Plus study: We are grateful for the collaborative efforts of all participating centenarians and their family members and/or relations. This work was supported by Stichting Alzheimer Nederland (WE09.2014-03), Stichting Diorapthe, horstingstuit foundation, Memorabel (ZonMW project number 733050814, 733050512) and Stichting VUmc Fonds. Genotyping of the 100-Plus Study was performed in the context of EADB (European Alzheimer DNA biobank) funded by the JPco-fuND FP-829-029 (ZonMW project number 733051061). Longitudinal Aging Study Amsterdam (LASA) is largely supported by a grant from the Netherlands Ministry of Health, Welfare and Sports, Directorate of Long-Term Care. The authors are grateful to all LASA participants, the fieldwork team and all researchers for their ongoing commitment to the study. This work was supported by a grant (European Alzheimer DNA BioBank, EADB) from the EU Joint Program—Neurodegenerative Disease Research (JPND) and also funded by Inserm, Institut Pasteur de Lille, the Lille Métropole Communauté Urbaine, the French government's LABEX DISTALZ program (development of innovative strategies for a transdisciplinary approach to AD). Genotyping of the German case-control samples was performed in the context of EADB (European Alzheimer DNA biobank) funded by the JPco-fuND (German Federal Ministry of Education and Research, BMBF: 01ED1619A). Full acknowledgments for the studies that contributed data can be found in the Supplementary Note. We thank the numerous participants, researchers, and staff from many studies who collected and contributed to the data. We thank the International Genomics of Alzheimer's Project (IGAP) for providing summary results data for these analyses. The investigators within IGAP contributed to the design and implementation of IGAP and/or provided data but did not participate in analysis or writing of this report. IGAP was made possible by the generous participation of the control subjects, the patients, and their families. The i–Select chips was funded by the French National Foundation on AD and related disorders. EADI was supported by the LABEX (laboratory of excellence program investment for the future) DISTALZ grant, Inserm, Institut Pasteur de Lille, Université de Lille 2 and the Lille University Hospital. GERAD was supported by the Medical Research Council (Grant n° 503480), Alzheimer's Research UK (Grant n° 503176), the Wellcome Trust (Grant n° 082604/2/07/Z) and German Federal Ministry of Education and Research (BMBF): Competence Network Dementia (CND) grant n° 01GI0102, 01GI0711, 01GI0420. CHARGE was partly supported by the NIA/NHLBI grants AG049505, AG058589, HL105756 and AGES contract N01–AG–12100, the Icelandic Heart Association, and the Erasmus Medical Center and Erasmus University. ADGC was supported by the NIH/NIA grants: U01 AG032984, U24 AG021886, U01 AG016976, and the Alzheimer's Association grant ADGC–10–196728. This research has been conducted using the UK Biobank public resource obtained through the University of Edinburg Data Share (https://datashare.is.ed.ac.uk/handle/10283/3364). ; Peer reviewed