Evolution of the human diet: the known, the unknown, and the unknowable – Edited by Peter S. Ungar
In: The journal of the Royal Anthropological Institute, Band 14, Heft 3, S. 675-677
ISSN: 1467-9655
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In: The journal of the Royal Anthropological Institute, Band 14, Heft 3, S. 675-677
ISSN: 1467-9655
In: The journal of the Royal Anthropological Institute, Band 13, Heft 4, S. 1048-1049
ISSN: 1467-9655
In: The journal of the Royal Anthropological Institute, Band 13, Heft 3, S. 764-765
ISSN: 1467-9655
In: The journal of the Royal Anthropological Institute, Band 12, Heft 3, S. 682-683
ISSN: 1467-9655
In: Current anthropology, Band 45, Heft S4, S. S59-S82
ISSN: 1537-5382
In: Human biology: the international journal of population genetics and anthropology ; the official publication of the American Association of Anthropological Genetics, Band 84, Heft 1, S. 45-66
ISSN: 1534-6617
In: Advances in Anthropology: AA, Band 2, Heft 1, S. 24-30
ISSN: 2163-9361
In: Advances in Anthropology: AA, Band 3, Heft 1, S. 33-37
ISSN: 2163-9361
Changes in potential regulatory elements are thought to be key drivers of phenotypic divergence. However, identifying changes to regulatory elements that underlie human-specific traits has proven very challenging. Here, we use 63 reconstructed and experimentally measured DNA methylation maps of ancient and present-day humans, as well as of six chimpanzees, to detect differentially methylated regions that likely emerged in modern humans after the split from Neanderthals and Denisovans. We show that genes associated with face and vocal tract anatomy went through particularly extensive methylation changes. Specifically, we identify widespread hypermethylation in a network of face- and voice-associated genes (SOX9, ACAN, COL2A1, NFIX and XYLT1). We propose that these repression patterns appeared after the split from Neanderthals and Denisovans, and that they might have played a key role in shaping the modern human face and vocal tract. ; D.G. is supported by the Clore Israel Foundation. TMB is supported by BFU2017-86471-P (MINECO/FEDER, UE), U01 MH106874 grant, Howard Hughes International Early Career, Obra Social "La Caixa" and Secretaria d'Universitats i Recerca and CERCA Program del Departament d'Economia i Coneixement de la Generalitat de Catalunya. D.R. is an Investigator of the Howard Hughes Medical Institute and is also supported by an Allen Discovery Center for the Study of Human Brain Evolution funded the Paul G. Allen Family Foundation. C.L.-F. is supported by FEDER and BFU2015-64699-P grant from the Spanish government. R.P. was supported by ERC starting grant ADNABIOARC (263441). R.M.G. and J.M.O. are supported by NYSTEM contract C030133. Funding for the collection and processing of the 850K chimpanzee data was provided by the Leakey Foundation Research Grant for Doctoral Students, Wenner-Gren Foundation Dissertation Fieldwork Grant (Gr. 9310), James F. Nacey Fellowship from the Nacey Maggioncalda Foundation, International Primatological Society Research Grant, Sigma Xi Grant-in-Aid of Research, Center for Evolution and Medicine Venture Fund (ASU), Graduate Research and Support Program Grant (GPSA, ASU), and Graduate Student Research Grant (SHESC, ASU) to G.H. Collection of the chimpanzee bone from Tanzania was funded by the Jane Goodall Institute, and grants from the US National Institutes of Health (AI 058715) and National Science Foundation (IOS-1052693), and facilitated by Elizabeth Lonsdorf and Beatrice Hahn. ; Peer reviewed
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