Open Access #3 2019
Bravo, Natalia ;
Grimalt, Joan O ;
Bocca, Beatrice ;
Pino, Anna ;
Bin, Maura ;
Brumatti, Liza Vecchi ;
Rosolen, Valentina ;
Barbone, Fabio ;
Ronfani, Luca ;
Alimonti, Alessandro ;
Calamandrei, Gemma Abstract Urinary metabolites of organophosphate (OP) and pyrethroid (PYR) pesticides from seven years old children of a birth cohort study (n=199; PHIME cohort of Trieste, Italy) have been measured. Six OP and two PYR metabolites have been investigated, 2-diethylamino-6-methylpyrimidin-4-ol (DEAMPY, pirimiphos metabolite) was the one found at higher concentrations, median 3.4 ng/mL specific gravity adjusted (SG adjusted), followed by 4-nitrophenol (PNP, median 1.4 ng/mL SG adjusted) and 3,5,6-trichloro-2-pyridinol (TCPY, median 0.36 ng/mL SG adjusted), parathion and chlorpyriphos metabolites, respectively. TCPY concentrations were low in comparison to other distributions of OP metabolites in children from other studies. Accordingly, the PHIME cohort showed a distinct OP metabolite distribution with high concentrations of pirimiphos and parathion. Another specific characteristic of this cohort was the high concentration of 3-phenoxybenzoic acid (3-BPA, median 0.36 ng/mL SG adjusted), a general metabolite of PYR pesticides. Evaluation of anthropometric and socio-demographic characteristics of children and families only showed a positive association between family educational level and urinary concentrations of DEAMPY metabolite (p<0.05), which could reflect distinct dietary habits depending on the educational level. Estimated daily intakes were evaluated, all studied metabolites were found within safe levels. © 2019 Elsevier Inc. ; Authors are grateful to the women who participated in our study as well as the people who helped in the recruitment in the different countries. This work was supported by the EU through its Sixth Framework Programme for RTD project PHIME (contract no FOOD-CT-2006- 016253), by GRANT LIFE 2012 ENV/GR/001040 "Crome Life - Cross Mediterranean Environment and Health Network", by European Union projects HEALS (FP7-ENV-2013- 603946) and Neurosome (H2020-MSCA-ITN-2017 SEP-210411486), by RC 12/12 of Institute for Maternal and Child Health -IRCCS "Burlo Garofolo" – Trieste – Italy funded by the Italian Ministry of Health. ; Peer reviewed