Suchergebnisse

The various analyses guided by the concept of development as a utopian horizon and how to achieve it inform an ideology of development in that they tend to dehistoricize "development" and thus present as natural its relations of domination and exploitation through a system of ideas that treats particular historical processes as if they could be universalized and particular political projects as if they were universal. This perception leads to hypotheses about this ideology of development focusing on its contemporary presence, its origins, its roots, its unfolding, its hegemony, its tendency toward economicism, and possible ways of moving beyond it. A focus on its contemporary presence contributes to the current critique of it in connection with the construction of a socialist strategy in Our America. As variadas análises orientadas pelo horizonte utópico do desenvolvimento e pautadas pela questão motora de "como se desenvolver" informam a ideologia do desenvolvimento, na medida em que tendem a desistoricizar o "desenvolvimento" e, desta forma, naturalizam as relações de dominação e exploração vigentes através de um sistema de ideias que apresenta determinados processos históricos particulares como passíveis de universalização e determinados projetos políticos particulares como sendo universais. Esta percepção traz consigo sete hipóteses sobre a ideologia do desenvolvimento, tratando de sua presença atual, origem, enraizamento, desdobramentos, hegemonia, tendência ao economicismo e, finalmente, possíveis formas de sua superação. O foco aqui se concentra na primeira hipótese, tendo em vista a relevância política atual da crítica à ideologia do desenvolvimento na construção de uma estratégia socialista em Nuestra América.

We present the first number of the third year of Rebela's existence with renewed satisfaction and commitment. Inaugurated in 2011, Rebela aim is to disseminate the production of Latin-American intellectuals and activists and to contribute to the construction and consolidation of a social thought based on the Marxist tradition, mainly in the Latin American Marxism. We are aware of the constrains faced by counter-hegemonic initiatives in the space of knowledge production and dissemination. The short life of Brazilian journals, mainly of those of open access and those positioned within this intellectual tradition, is a ghost surrounding editors and authors. Usually, the evaluative process to which the journals and authors are subject is determinant to this discontinuity. During these two years of Rebela we were able to fulfill the initial aims and to go through the institutional evaluation. As it we mentioned in the previous Editorial, Rebela has been officially recognized by CAPES and included in its Qualis. We thank all that, believing in this initiative, submitted papers, evaluated and published in Rebela. Under the dominance of productivism and impact factors, the act of collaborating with this journal is, above all, a political act. In the same way, the institutional recognition re-affirms our commitment to disseminate the critical Latin American thought in the academy without limiting ourselves to it. This is way theory and practice, action and reflection, context and social totality, are the categories around which we organize one more issue of Rebela, as it will be seen in the papers included.

Editorial do número América Latina, experiências socialistas e educação

Multiple sequence alignment (MSA) is crucial for high-throughput next generation sequencing applications. Large-scale alignments with thousands of sequences are necessary for these applications. However, the quality of the alignment of current MSA tools decreases sharply when the number of sequences grows to several thousand. This accuracy degradation can be mitigated using global consistency information as in the T-Coffee MSA-Tool, which implements a consistency library. However, consistency-based methods do not scale well because of the computational resources required to calculate and store the consistency information, which grows quadratically. In this paper, we propose an alternative method for building the consistency-library. To allow unlimited scalability, consistency information must be discarded to avoid exceeding the environment memory. Our first approach deals with the memory limitation by identifying the most important entries, which provide better consistency. This method is able to achieve scalability, although there is a negative impact on accuracy. The second proposal, aims to reduce this degradation of accuracy, with three different methods presented to attain a better alignment. ; This work has been supported by the Government of Spain TIN2011-28689-C02-02. Cedric Notredame is funded by the Plan Nacional BFU2011-28575 and The Quantomics project (KBBE- 2A-222664).

26 p.-5 fig.-5 tab. ; Microtubules (MTs) are hollow cylinders made of tubulin, a GTPase responsible for essential functions during cell growth and division, and thus, key target for anti-tumor drugs. In MTs, GTP hydrolysis triggers structural changes in the lattice, which are responsible for interaction with regulatory factors. The stabilizing GTP-cap is a hallmark of MTs and the mechanism of the chemical-structural link between the GTP hydrolysis site and the MT lattice is a matter of debate. We have analyzed the structure of tubulin and MTs assembled in the presence of fluoride salts that mimic the GTP-bound and GDP•Pi transition states. Our results challenge current models because tubulin does not change axial length upon GTP hydrolysis. Moreover, analysis of the structure of MTs assembled in the presence of several nucleotide analogues and of taxol allows us to propose that previously described lattice expansion could be a post-hydrolysis stage involved in Pi release. ; This work was supported by Ministerio de Economia y Competitividad grants BFU2013-47014-P to MAO and BFU2016-75319-R to FDP (both AEI/FEDER, UE); Ministerio de Ciencia e Innovación RYC-2011–07900 to MAO; European Union H2020-MSCA-ITN-ETN/0582 ITN TubInTrain to FDP and AEP; Swiss National Science Foundation (31003A_166608) to MOS; JSPS KAKENHI (16K07328/17H03668) to SK; (FSE) ANR-16-CE11-0017-01 to DC and LD. JE-G was supported by Ministerio de Educación, Cultura y Deporte FPU15-03140 and SK by French Ministry of Higher Education of Research and Innovation (IGDR). Cryo-EM data were adquired on the MRic platform (Univ. Rennes, CNRS, Inserm, BIOSIT-UMS 3480, US_S 018, F-35000 Rennes, France). The authors acknowledge networking contribution by the COST Action CM1407 "Challenging organic syntheses inspired by nature - from natural products chemistry to drug discovery" ; Peer reviewed