Suchergebnisse

This book is devoted to biased sampling problems (also called choice-based sampling in Econometrics parlance) and over-identified parameter estimation problems. Biased sampling problems appear in many areas of research, including Medicine, Epidemiology and Public Health, the Social Sciences and Economics. The book addresses a range of important topics, including case and control studies, causal inference, missing data problems, meta-analysis, renewal process and length biased sampling problems, capture and recapture problems, case cohort studies, exponential tilting genetic mixture models etc. The goal of this book is to make it easier for Ph. D students and new researchers to get started in this research area. It will be of interest to all those who work in the health, biological, social and physical sciences, as well as those who are interested in survey methodology and other areas of statistical science, among others

Seit der englische Biologe Alec Jeffreys aus Leicester den genetischen Fingerabdruck erfand, wurde dieser schnell zu einem wichtigen rechtsmedizinischen Erkenntnismittel, insbesondere im Bereich der Aufklärung von Sexualstraftaten und Mordfällen. Die Verwendung der Technik als erkennungsdienstliche Maßnahme bei der Ermittlung in künftigen Strafverfahren wirft eine Reihe von verfassungsrechtlichen Fragen auf. Diese Arbeit untersucht rechtsvergleichend die Entwicklung des rechtlichen Umgangs mit DNA-Analysen zur Verbrechensbekämpfung und DNA-Datenbanken in den USA, Großbritannien, Deutschland, Hongkong und Singapur. ; The use of the deoxyribonucleic acid (the "DNA") been widely used to identify suspects and solve crimes, thus leading to the tremendous growth of its importance in criminal justice system in different countries. The numbers of countries having their DNA databanks are increasing in recent years. However, the use of the DNA has been legally challenged in particular in the area related to the protection civil liberties. This paper compares and analyzes the development of the use of the DNA in the United Kingdom, United States of America, Germany, Hong Kong and Singapore on a comparative basis. Focuses are placed on how these countries legislate along with the use of the DNA and in that context how they resolve the issues on the protection of civil liberties.

Zusammenfassung: Seit der englische Biologe Alec Jeffreys aus Leicester den genetischen Fingerabdruck erfand, wurde dieser schnell zu einem wichtigen rechtsmedizinischen Erkenntnismittel, insbesondere im Bereich der Aufklärung von Sexualstraftaten und Mordfällen. Die Verwendung der Technik als erkennungsdienstliche Maßnahme bei der Ermittlung in künftigen Strafverfahren wirft eine Reihe von verfassungsrechtlichen Fragen auf. Diese Arbeit untersucht rechtsvergleichend die Entwicklung des rechtlichen Umgangs mit DNA-Analysen zur Verbrechensbekämpfung und DNA-Datenbanken in den USA, Großbritannien, Deutschland, Hongkong und Singapur

Ongoing Ebola virus disease outbreaks in the Democratic Republic of the Congo follow the largest recorded outbreak in Western Africa (2013–2016). To combat outbreaks, testing of medical countermeasures (therapeutics or vaccines) requires a well-defined, reproducible, animal model. Here we present Ebola virus disease kinetics in 24 Chinese-origin rhesus monkeys exposed intramuscularly to a highly characterized, commercially available Kikwit Ebola virus Filovirus Animal Non-Clinical Group (FANG) stock. Until reaching predetermined clinical disease endpoint criteria, six animals underwent anesthesia for repeated clinical sampling and were compared to six that did not. Groups of three animals were euthanized and necropsied on days 3, 4, 5, and 6 post-exposure, respectively. In addition, three uninfected animals served as controls. Here, we present detailed characterization of clinical and laboratory disease kinetics and complete blood counts, serum chemistries, Ebola virus titers, and disease kinetics for future medical countermeasure (MCM) study design and control data. We measured no statistical difference in hematology, chemistry values, or time to clinical endpoint in animals that were anesthetized for clinical sampling during the acute disease compared to those that were not.