In: Human biology: the international journal of population genetics and anthropology ; the official publication of the American Association of Anthropological Genetics, Band 84, Heft 3, S. 1-3
In 1956, evolutionary biologist J.B.S. Haldane posed a question to anthropologists: "Are the biological differences between human groups comparable with those between groups of domestic animals such as greyhounds and bulldogs…?" It reads as if it were posted on social media today. The analogy comparing human races to dog breeds is not only widespread in history and pop culture, but also sounds like scientific justification for eschewing the social construction of race, or for holding racist beliefs about human nature. Here we answer Haldane's question in an effort to improve the public understanding of human biological variation and "race"—two phenomena that are not synonymous. Speaking to everyone without expert levels of familiarity with this material, we investigate whether the dog breed analogy for human race stands up to biology. It does not. Groups of humans that are culturally labeled as "races" differ in population structure, genotype–phenotype relationships, and phenotypic diversity from breeds of dogs in unsurprising ways, given how artificial selection has shaped the evolution of dogs, not humans. Our demonstration complements the vast body of existing knowledge about how human "races" differ in fundamental sociocultural, historical, and political ways from categories of nonhuman animals. By the end of this paper, readers will understand how the assumption that human races are the same as dog breeds is a racist strategy for justifying social, political, and economic inequality.
Changes in potential regulatory elements are thought to be key drivers of phenotypic divergence. However, identifying changes to regulatory elements that underlie human-specific traits has proven very challenging. Here, we use 63 reconstructed and experimentally measured DNA methylation maps of ancient and present-day humans, as well as of six chimpanzees, to detect differentially methylated regions that likely emerged in modern humans after the split from Neanderthals and Denisovans. We show that genes associated with face and vocal tract anatomy went through particularly extensive methylation changes. Specifically, we identify widespread hypermethylation in a network of face- and voice-associated genes (SOX9, ACAN, COL2A1, NFIX and XYLT1). We propose that these repression patterns appeared after the split from Neanderthals and Denisovans, and that they might have played a key role in shaping the modern human face and vocal tract. ; D.G. is supported by the Clore Israel Foundation. TMB is supported by BFU2017-86471-P (MINECO/FEDER, UE), U01 MH106874 grant, Howard Hughes International Early Career, Obra Social "La Caixa" and Secretaria d'Universitats i Recerca and CERCA Program del Departament d'Economia i Coneixement de la Generalitat de Catalunya. D.R. is an Investigator of the Howard Hughes Medical Institute and is also supported by an Allen Discovery Center for the Study of Human Brain Evolution funded the Paul G. Allen Family Foundation. C.L.-F. is supported by FEDER and BFU2015-64699-P grant from the Spanish government. R.P. was supported by ERC starting grant ADNABIOARC (263441). R.M.G. and J.M.O. are supported by NYSTEM contract C030133. Funding for the collection and processing of the 850K chimpanzee data was provided by the Leakey Foundation Research Grant for Doctoral Students, Wenner-Gren Foundation Dissertation Fieldwork Grant (Gr. 9310), James F. Nacey Fellowship from the Nacey Maggioncalda Foundation, International Primatological Society Research Grant, Sigma Xi Grant-in-Aid of Research, Center for Evolution and Medicine Venture Fund (ASU), Graduate Research and Support Program Grant (GPSA, ASU), and Graduate Student Research Grant (SHESC, ASU) to G.H. Collection of the chimpanzee bone from Tanzania was funded by the Jane Goodall Institute, and grants from the US National Institutes of Health (AI 058715) and National Science Foundation (IOS-1052693), and facilitated by Elizabeth Lonsdorf and Beatrice Hahn. ; Peer reviewed