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Association of Inflammation Genes with Alcohol Dependence/Abuse: A Systematic Review and a Meta-Analysis
In: European addiction research, Band 17, Heft 3, S. 146-153
ISSN: 1421-9891
The aim of the present work was to systematically review all association studies of inflammation genes with alcohol dependence/alcohol abuse (AD/AA) and to perform a meta-analysis. Odds ratios (ORs) were estimated by contrasting the ratio of counts of the 'high-risk' versus 'low-risk' alleles in AD/AA cases versus controls. Data reported in at least three published studies were available for four genetic polymorphisms [<i>TNF-</i>α -238 (rs361525, G/A); <i>TNF-</i>α -308 (rs1800629, G/A); <i>IL-1RA</i> (VNTR [86 bp]<sub>n</sub>); <i>IL-10</i> -592 (rs1800896, C/A)]. In total, nine meta-analyses were performed. Of these, only the <i>TNF-</i>α -238 polymorphism showed a significant association with AD/AA (OR = 1.36, 95% CI: 1.05–1.76). This risk remained significant and increased slightly when we considered only patients with advanced alcohol-related liver disease (AALD) (OR = 1.5, 95% CI: 1.13–1.98) but not when we considered only patients without AALD (OR = 1.08, 95% CI: 0.5–2.35). Sensitivity analysis showed that this genetic association is derived from the AALD phenotype rather than from AD. Our approach is limited by our phenotype definition; some studies included chronic heavy drinkers (minimal daily consumption of 80 g for a minimal duration of 10 years) but without a standardized psychiatric assessment.
DOSE–EFFECT RELATION BETWEEN DAILY ETHANOL INTAKE IN THE RANGE 0–70 GRAMS AND %CDT VALUE: VALIDATION OF A CUT-OFF VALUE
In: Alcohol and alcoholism: the international journal of the Medical Council on Alcoholism (MCA) and the journal of the European Society for Biomedical Research on Alcoholism (ESBRA), Band 40, Heft 6, S. 531-534
ISSN: 1464-3502
A Randomized, Placebo-Controlled Study of High-Dose Baclofen in Alcohol-Dependent Patients—The ALPADIR Study
In: Alcohol and alcoholism: the international journal of the Medical Council on Alcoholism (MCA) and the journal of the European Society for Biomedical Research on Alcoholism (ESBRA), Band 52, Heft 4, S. 439-446
ISSN: 1464-3502