Book Reviews
In: Indian journal of public administration, Band 5, Heft 1, S. 113-114
ISSN: 2457-0222
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In: Indian journal of public administration, Band 5, Heft 1, S. 113-114
ISSN: 2457-0222
In: Defence science journal: DSJ, Band 60, Heft 5, S. 476-482
ISSN: 0011-748X
In: Defence science journal: a journal devotet to science & technology in defence, Band 60, Heft 5, S. 476-483
ISSN: 0011-748X
In: Defence science journal: DSJ, Band 59, Heft 3, S. 294-299
ISSN: 0011-748X
In: Defence science journal: DSJ, Band 45, Heft 1, S. 31-34
ISSN: 0011-748X
Posttraumatic stress disorder (PTSD) is a major problem among military veterans and civilians alike, yet its pathophysiology remains poorly understood. We used genomewide association study (GWAS) and bioinformatic analyses, including 146,660 European-Americans (EAs) and 19,983 African-Americans (AAs) in the US Million Veteran Program, to identify genetic risk factors relevant to Intrusive reexperiencing of trauma -- the most characteristic symptom cluster of PTSD. In EAs, 8 distinct significant regions were identified. Three regions had P<5×10(−10) -- CAMKV; chromosome 17 closest to KANSL1 but within a large high-LD region that also includes CRHR1; and TCF4. Associations were enriched with respect to the transcriptomic profiles of striatal medium spiny neurons. No significant associations were observed in the AA part of the sample. Results in EAs were replicated in UK Biobank. These results provide new insights into the biology of PTSD in a well--powered GWAS.
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