Open Access#12017
Clinical use of adipose-derived stem cells: European legislative issues
•We analyse the current European legislation in order to provide guidance for regenerative medicine professionals.•Collagenase digestion, as well as cell culturing, is considered to be a substantial manipulation.•Only transplantation of a non-manipulated tissue to the same histological environment is considered to be homologous.•ASCs should be not-cultured, isolated mechanically and used only in the subcutaneous tissue.