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The urgent nature of epidemic infectious diseasesbring specific challenges in disease control. Epidemicscan cause immediate health, social and economicimpacts, and require complex cross-sectoral andglobal response as illustrated by the 2014 Ebolaepidemic. Travel and globalisation mean thatinfections spread rapidly around the world, so thatglobal solutions are required for epidemic control.Recent developments in artificially engineeredpathogens (dual-use research of concern) posean added complexity to global biosecurity. Globalsystems, thinking and capability in biosecurity haslagged behind quantum changes in science, leavingus more vulnerable than ever to infectious diseasesepidemics. This Centre addresses critical systems gaps in epidemic control.The NHMRC Centre for Research Excellence,Integrated Systems for Epidemic Response (ISER)conduct applied systems research, enhancecollaboration and build capacity in health systemsresearch for epidemic control. We bring togetherexperts in field epidemiology and epidemic response,military experts, international law and risk scienceexperts, and government and non-governmentagencies involved in epidemic response. The ARMNetwork for epidemic response is central to theCRE, with the co-founders all being part of theCRE. This Centre is international, with partnersin Australia, New Zealand, USA, China, Malaysiaand Indonesia who work together to solve globalproblems in epidemic response. A pillar of theCRE is ISER Academy, which is a think-tank andconvenor of important dialogue, capacity buildingand generation of ideas, between all stakeholdersand sectors involved in epidemic response.ISER is conducting research in three main areas:1) Epidemic response, control and prevention, 2)Epidemic intelligence and risk analysis and 3) theestablishment of the ISER academy, a think tank ofepidemic experts and stakeholders for the purposeof sharing information, collaboration and developingsolutions. This presentation will outline the workof ISER, the initial results of early research effortsacross the three main research areas, collaborationopportunities for military personnel interested inbioterrorism, biosecurity and epidemic responseresearch careers, and future directions for researchconducted by ISER.

The urgent nature of epidemic infectious diseasesbring specific challenges in disease control. Epidemicscan cause immediate health, social and economicimpacts, and require complex cross-sectoral andglobal response as illustrated by the 2014 Ebolaepidemic. Travel and globalisation mean thatinfections spread rapidly around the world, so thatglobal solutions are required for epidemic control.Recent developments in artificially engineeredpathogens (dual-use research of concern) posean added complexity to global biosecurity. Globalsystems, thinking and capability in biosecurity haslagged behind quantum changes in science, leavingus more vulnerable than ever to infectious diseasesepidemics. This Centre addresses critical systems gaps in epidemic control.The NHMRC Centre for Research Excellence,Integrated Systems for Epidemic Response (ISER)conduct applied systems research, enhancecollaboration and build capacity in health systemsresearch for epidemic control. We bring togetherexperts in field epidemiology and epidemic response,military experts, international law and risk scienceexperts, and government and non-governmentagencies involved in epidemic response. The ARMNetwork for epidemic response is central to theCRE, with the co-founders all being part of theCRE. This Centre is international, with partnersin Australia, New Zealand, USA, China, Malaysiaand Indonesia who work together to solve globalproblems in epidemic response. A pillar of theCRE is ISER Academy, which is a think-tank andconvenor of important dialogue, capacity buildingand generation of ideas, between all stakeholdersand sectors involved in epidemic response.ISER is conducting research in three main areas:1) Epidemic response, control and prevention, 2)Epidemic intelligence and risk analysis and 3) theestablishment of the ISER academy, a think tank ofepidemic experts and stakeholders for the purposeof sharing information, collaboration and developingsolutions. This presentation will outline the workof ISER, the initial results of early research effortsacross the three main research areas, collaborationopportunities for military personnel interested inbioterrorism, biosecurity and epidemic responseresearch careers, and future directions for researchconducted by ISER.

In 2016, the Transplantation Society of Australia and New Zealand, with the support of the Australian Government Organ and Tissue authority, commissioned a literature review on the topic of infectious disease transmission from deceased donors to recipients of solid organ transplants. The purpose of this review was to synthesize evidence on transmission risks, diagnostic test characteristics, and recipient management to inform best-practice clinical guidelines. The final review, presented as a special supplement in Transplantation Direct, collates case reports of transmission events and other peer-reviewed literature, and summarizes current (as of June 2017) international guidelines on donor screening and recipient management. Of particular interest at the time of writing was how to maximize utilization of donors at increased risk for transmission of human immunodeficiency virus, hepatitis C virus, and hepatitis B virus, given the recent developments, including the availability of direct-acting antivirals for hepatitis C virus and improvements in donor screening technologies. The review also covers emerging risks associated with recent epidemics (eg, Zika virus) and the risk of transmission of nonendemic pathogens related to donor travel history or country of origin. Lastly, the implications for recipient consent of expanded utilization of donors at increased risk of blood-borne viral disease transmission are considered.