The aim of this article is to highlight the little-known, but influential role Jesús Aguirre played in Spanish intellectual and cultural life throughout his career. His role as a communicator serves as a link, giving a sense of continuity through his different occupations as a priest, translator, editor, aristocrat, socialite and writer. Some of his most notable contributions include his role in fostering the Marxist-Christian dialogue, as well as the introduction and promotion in Spain of the thought of the Frankfurt School, which in turn had an impact on the intellectual coordinates which marked the Spanish Transition to democracy.
José Luis López Aranguren is often described as a Catholic thinker. The purpose of this article is to contextualize this qualification, while emphasizing the evolution of his thought towards increasingly critical and provocative positions on issues of socio-political nature, as observed in his work on neo-capitalism society and on democracy.
Canada admits between 22,000 - 24,000 refugees each year (Beiser, 2005). Immigrants and visible minorities tend to underutilize mental health services. However, ensuring new settlers' physical and mental health is not only humane, but also crucial to enable them to achieve their social and economic potential in the host country. Fundamentally, the need for Multicultural Counselling Competencies (MCC) is due to diverging notions of mental health and healing between clients and therapists who are culturally different from each other. There is ample literature on Multicultural Counselling Competencies. However most of this body of research has been conducted using quantitative approaches. The present study is a qualitative analysis which aimed to answer the research question: "What are therapist-trainees' experiences regarding their Multicultural Counselling Competencies (MCC) while providing therapy to firstgeneration, government assisted, refugee clients?". The sample for this study consisted of fourteen therapist-trainees who were doctoral level students in the Clinical Psychology program, Adult Track, at the University of Windsor. These therapist-trainees completed Critical Incident Journal (CIJ) entries after each session with their refugee clients. The therapist-trainees completed a total of 165 CIJ entries. These entries were analyzed using an adaptation of the Grounded Theory Method (GTM) as a guiding framework (Rennie, 2006). Three main themes emerged from the therapists CIJs: "Feeling the Need to Adapt", "Feeling a Sense of Increasing Cultural Self-Awareness" and "Building the Therapeutic Relationship is Important". In addition, developmental aspects of the therapists' experiences were identified. Implications for future training, practice and research are discussed.
AbstractWe consider the optimal replacement problem for a fault tolerant system comprised of N components. The components are distingushable, and the state of the system is given by knowing exactly which components are operationl and which have failed. The individual component failure rates depend on the state of the entire system. We assume that the rate at which the system produces income decreases as the system deteriorates and the system replacement cost rises. Individual components cannot be replaced. We give a greedy‐type algorithm that produces the replacement policy that maximizes the long‐run net system income per unit time.
Las empresas cuentan con clientes externos e internos; los colaboradores internos al ser evaluados por el desempeño demuestran algún tipo de resistencia y su percepción requiere una evaluación muy objetiva, debido a que al ser consultados por el grado de satisfacción respecto al trabajo muestran diferentes concepciones de las labores administrativas. En esta perspectiva, medir la satisfacción que tienen en sus labores administrativas es primordial para llevar a cavo una mejora continua de procesos con colaboradores empoderados en la consecución de objetivos empresariales. Para este efecto se usa el modelo SERVQUAL que usa dos niveles de 5 dimensiones las expectativas y las percepciones. La metodología a seguir tiene que ver enteramente con la medición de las dimensiones en el SERVQUAL.
Trehalose analogues bearing fluorescent and click chemistry tags have been developed as probes of bacterial trehalose metabolism, but these tools have limitations with respect to in vivo imaging applications. Here, we report the radiosynthesis of the F-18-modified trehalose analogue 2-deoxy-2-[F-18]fluoro-D-trehalose ([F-18]-2-FDTre), which in principle can be used in conjunction with positron emission tomography (PET) imaging to allow in vivo imaging of trehalose metabolism in various contexts. A chemoenzymatic method employing the thermophilic TreT enzyme from Thermoproteus tenax was used to rapidly (15-20 min), efficiently (70% radiochemical yield; >= 95% radiochemical purity), and reproducibly convert the commercially available radiotracer 2-deoxy-2-[F-18]fluoro-D-glucose ([F-18]-2-FDG) into the target radioprobe [F-18]-2-FDTre in a single step; both manual and automated syntheses were performed with similar results. Cellular uptake experiments showed that radiosynthetic [F-18]-2-FDTre was metabolized by Mycobacterium smegmatis but not by various mammalian cell lines, pointing to the potential future use of this radioprobe for selective PET imaging of infections caused by trehalose-metabolizing bacterial pathogens such as M. tuberculosis. ; This work was funded by a grant from the National Institutes of Health, United States (R15 AI117670) to B.M.S. and P.J.W., as well as a Henry Dreyfus Teacher-Scholar Award from The Camille & Henry Dreyfus Foundation to B.M.S. (TH-17-034). A.Y.-T.H was supported by the Mount Holyoke College Lynk program. Dr. Wenyan Xu is thanked for assistance with kinetic analysis. The research leading to these results received funding from the Innovative Medicines Initiative, European Union (www.imi.europa.eu) Joint Undertaking under grant agreement no. 115337, whose resources comprise funding from EU FP7/2007-2013 and EFPIA, European Union companies in-kind contribution. This work was partially supported by the Ministry of Economy and Competitiveness, Spain TEC2015-73064-EXP and TEC2016-78052-R, ISCIII-FIS grants PI16/02037, co-financed by ERDF, European Union (FEDER) Funds from the European Commission, European Union, "A way of making Europe".
Background: Low-risk limits recommended for alcohol consumption vary substantially across different national guidelines. To define thresholds associated with lowest risk for all-cause mortality and cardiovascular disease, we studied individual-participant data from 599 912 current drinkers without previous cardiovascular disease. Methods: We did a combined analysis of individual-participant data from three large-scale data sources in 19 high-income countries (the Emerging Risk Factors Collaboration, EPIC-CVD, and the UK Biobank). We characterised dose–response associations and calculated hazard ratios (HRs) per 100 g per week of alcohol (12·5 units per week) across 83 prospective studies, adjusting at least for study or centre, age, sex, smoking, and diabetes. To be eligible for the analysis, participants had to have information recorded about their alcohol consumption amount and status (ie, non-drinker vs current drinker), plus age, sex, history of diabetes and smoking status, at least 1 year of follow-up after baseline, and no baseline history of cardiovascular disease. The main analyses focused on current drinkers, whose baseline alcohol consumption was categorised into eight predefined groups according to the amount in grams consumed per week. We assessed alcohol consumption in relation to all-cause mortality, total cardiovascular disease, and several cardiovascular disease subtypes. We corrected HRs for estimated long-term variability in alcohol consumption using 152 640 serial alcohol assessments obtained some years apart (median interval 5·6 years [5th–95th percentile 1·04–13·5]) from 71 011 participants from 37 studies. Findings: In the 599 912 current drinkers included in the analysis, we recorded 40 310 deaths and 39 018 incident cardiovascular disease events during 5·4 million person-years of follow-up. For all-cause mortality, we recorded a positive and curvilinear association with the level of alcohol consumption, with the minimum mortality risk around or below 100 g per week. Alcohol consumption was roughly linearly associated with a higher risk of stroke (HR per 100 g per week higher consumption 1·14, 95% CI, 1·10–1·17), coronary disease excluding myocardial infarction (1·06, 1·00–1·11), heart failure (1·09, 1·03–1·15), fatal hypertensive disease (1·24, 1·15–1·33); and fatal aortic aneurysm (1·15, 1·03–1·28). By contrast, increased alcohol consumption was log-linearly associated with a lower risk of myocardial infarction (HR 0·94, 0·91–0·97). In comparison to those who reported drinking >0–≤100 g per week, those who reported drinking >100–≤200 g per week, >200–≤350 g per week, or >350 g per week had lower life expectancy at age 40 years of approximately 6 months, 1–2 years, or 4–5 years, respectively. Interpretation: In current drinkers of alcohol in high-income countries, the threshold for lowest risk of all-cause mortality was about 100 g/week. For cardiovascular disease subtypes other than myocardial infarction, there were no clear risk thresholds below which lower alcohol consumption stopped being associated with lower disease risk. These data support limits for alcohol consumption that are lower than those recommended in most current guidelines. Funding: UK Medical Research Council, British Heart Foundation, National Institute for Health Research, European Union Framework 7, and European Research Council.
BACKGROUND: Low-risk limits recommended for alcohol consumption vary substantially across different national guidelines. To define thresholds associated with lowest risk for all-cause mortality and cardiovascular disease, we studied individual-participant data from 599 912 current drinkers without previous cardiovascular disease. METHODS: We did a combined analysis of individual-participant data from three large-scale data sources in 19 high-income countries (the Emerging Risk Factors Collaboration, EPIC-CVD, and the UK Biobank). We characterised dose-response associations and calculated hazard ratios (HRs) per 100 g per week of alcohol (12·5 units per week) across 83 prospective studies, adjusting at least for study or centre, age, sex, smoking, and diabetes. To be eligible for the analysis, participants had to have information recorded about their alcohol consumption amount and status (ie, non-drinker vs current drinker), plus age, sex, history of diabetes and smoking status, at least 1 year of follow-up after baseline, and no baseline history of cardiovascular disease. The main analyses focused on current drinkers, whose baseline alcohol consumption was categorised into eight predefined groups according to the amount in grams consumed per week. We assessed alcohol consumption in relation to all-cause mortality, total cardiovascular disease, and several cardiovascular disease subtypes. We corrected HRs for estimated long-term variability in alcohol consumption using 152 640 serial alcohol assessments obtained some years apart (median interval 5·6 years [5th-95th percentile 1·04-13·5]) from 71 011 participants from 37 studies. FINDINGS: In the 599 912 current drinkers included in the analysis, we recorded 40 310 deaths and 39 018 incident cardiovascular disease events during 5·4 million person-years of follow-up. For all-cause mortality, we recorded a positive and curvilinear association with the level of alcohol consumption, with the minimum mortality risk around or below 100 g per week. Alcohol consumption was roughly linearly associated with a higher risk of stroke (HR per 100 g per week higher consumption 1·14, 95% CI, 1·10-1·17), coronary disease excluding myocardial infarction (1·06, 1·00-1·11), heart failure (1·09, 1·03-1·15), fatal hypertensive disease (1·24, 1·15-1·33); and fatal aortic aneurysm (1·15, 1·03-1·28). By contrast, increased alcohol consumption was log-linearly associated with a lower risk of myocardial infarction (HR 0·94, 0·91-0·97). In comparison to those who reported drinking >0-≤100 g per week, those who reported drinking >100-≤200 g per week, >200-≤350 g per week, or >350 g per week had lower life expectancy at age 40 years of approximately 6 months, 1-2 years, or 4-5 years, respectively. INTERPRETATION: In current drinkers of alcohol in high-income countries, the threshold for lowest risk of all-cause mortality was about 100 g/week. For cardiovascular disease subtypes other than myocardial infarction, there were no clear risk thresholds below which lower alcohol consumption stopped being associated with lower disease risk. These data support limits for alcohol consumption that are lower than those recommended in most current guidelines. FUNDING: UK Medical Research Council, British Heart Foundation, National Institute for Health Research, European Union Framework 7, and European Research Council.