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World Affairs Online
Interview with Wim Delvoye ; Entrevista a Wim Delvoye
Wim Delvoye is a multidisciplinary artist who lives and works in Ghent (Belgium) and in Brighton (United Kingdom). His artistic projects focus on various issues of contemporary society and subliminal messages existing in advertising, political and religious discourses. His critical and parodic view of reality opens the debate not only on the eternal discussion about what is art and what is not, but also in relation to who determines this distinction. On this sense the artist is fascinated by crafts and popular culture. Immersed in this current context, the subject constructs an unique identity through editing his own body with tattoos, and assumes a personal anthropological and artistic discourse exhibiting their exclusive marks of differentiation. In the mid-1990s Wim Delvoye began tattooing animals and quickly his works of tattooed dead chickens and living pigs crossed that tiny line between ethics and aesthetics. At the same time, they propose other ways of distribution, commercialization and exhibition, some because of being perishable and others for being live animals. A little more than a decade later, the artist started the Art Farm Project in Beijing in which he continued using tattoos on pigs' skin. In 2006 Delvoye began one of his most controversial works tattooing the Tim Steiner's back. An anonymous person that from being tattooed by the artist became simultaneously an edited body and an artistic object (Art Farm-Tim, 2008). Through this interview, SOBRE N06 proposes to display all aspects that concern these projects and the particular circumstances regarding to their sale and exhibition. ; Wim Delvoye es un artista multidisciplinar que vive y trabaja entre Gante (Bélgica) y Brighton (Reino Unido). Sus proyectos artísticos se centran en aspectos diversos de la sociedad contemporánea, así como en los mensajes subliminales existentes en la publicidad y en los discursos políticos y religiosos. Su visión crítica y paródica de la realidad abre un debate que va más allá de la eterna discusión entre lo que ...
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Feasibility and Safety of Bridging Antiplatelet Therapy with Cangrelor in Neuro-Oncology: A Preliminary Experience
In: Journal of neurological surgery. Part A, Central European neurosurgery = Zentralblatt für Neurochirurgie
ISSN: 2193-6323
AbstractAntiplatelet therapy is mandatory for prevention of thrombotic events in patients with a recent history of acute coronary syndromes and/or percutaneous coronary interventions. However, if an urgent surgery is required during antiplatelet therapy, a compromise between the ischemic/thrombotic and hemorrhagic risk has to be reached. Different bridging schemes are reported in the literature, but there is no clear consensus on the optimal treatment strategy in terms of efficacy and safety. Although some indications about the perioperative management of antiplatelet therapy regarding specific surgical specializations are available, balancing the thrombotic and hemorrhagic risk on an individual basis, no evidence referring to neurosurgical or neuro-oncologic procedures is reported. Herein, we present our preliminary experience in the perioperative management of a patient who underwent a neurosurgical procedure for the resection of a primary malignant brain tumor using an intravenous P2Y12 inhibitor (cangrelor) as bridging therapy after a recent acute myocardial infarction treated with primary percutaneous coronary intervention and stenting. The oral P2Y12 inhibitor (clopidogrel) was withdrawn 5 days prior to the surgical procedure and continuous infusion of cangrelor was started 3 days before the surgery at a dose of 0.75 μg/kg/min. Cangrelor was discontinued 2 hours before surgery and resumed 72 hours after tumor resection for further 60 hours. Neither cangrelor-related bleeding nor cardiac ischemic events were observed in the perioperative period and the following 90 days, supporting data regarding the feasibility and safety of this bridging scheme. Further studies are needed to confirm our promising results.
How do 66 European institutional review boards approve one protocol for an international prospective observational study on traumatic brain injury? Experiences from the CENTER-TBI study
Abstract: Background: The European Union (EU) aims to optimize patient protection and efficiency of health-care research by harmonizing procedures across Member States. Nonetheless, further improvements are required to increase multicenter research efficiency. We investigated IRB procedures in a large prospective European multicenter study on traumatic brain injury (TBI), aiming to inform and stimulate initiatives to improve efficiency. Methods: We reviewed relevant documents regarding IRB submission and IRB approval from European neurotrauma centers participating in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI). Documents included detailed information on IRB procedures and the duration from IRB submission until approval(s). They were translated and analyzed to determine the level of harmonization of IRB procedures within Europe. Results: From 18 countries, 66 centers provided the requested documents. The primary IRB review was conducted centrally (N = 11, 61%) or locally (N = 7, 39%) and primary IRB approval was obtained after one (N = 8, 44%), two (N = 6, 33%) or three (N = 4, 23%) review rounds with a median duration of respectively 50 and 98 days until primary IRB approval. Additional IRB approval was required in 55% of countries and could increase duration to 535 days. Total duration from submission until required IRB approval was obtained was 114 days (IQR 75–224) and appeared to be shorter after submission to local IRBs compared to central IRBs (50 vs. 138 days, p = 0.0074). Conclusion: We found variation in IRB procedures between and within European countries. There were differences in submission and approval requirements, number of review rounds and total duration. Research collaborations could benefit from the implementation of more uniform legislation and regulation while acknowledging local cultural habits and moral values between countries.
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