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International audience ; Reviewers' comments: Reviewer #1: Comments to Editor The manuscript "Increase of precuneus metabolism correlates with reduction of PTSD symptoms after EMDR therapy in military veterans: an 18F-FDG PET study during virtual reality exposure to war" by Rousseau et al deals with very actual topic: the disclosure of the neurobiology of psychotherapies. Furthermore, approaching such matter by PET activation studies, after about 30 years since the first 15O-H2O ones, using FDG might start a new season for this fascinating research field The manuscript is concise, well written and pretty clear in the aims, methods, results and discussion and in my opinion misses only a few information that will would improve its quality. I have a general comment and some minor specific remarks General comments The authors have recently published on the EJNMMI an editorial promoting functional 18F-FDG PET brain activation imaging. A similar study to the present one was published on the same Journal in 2015 (Eur J Nucl Med Mol Imaging (2015) 42:733-740) in which the very same protocol and methodology were used with the only difference that the stressing stimulus was olfactory and not visual. Since the readers of the present paper will be (firstly) nuclear medicine physicians it is opinion of this reviewer that the above paper should be quoted and the methodology implemented in both of them better "promoted" in the introduction and discussion to stimulate the colleagues to perform similar studies. It is also the opinion of this reviewer that it is a pity that the authors decided to submit such interesting and groundbreaking paper as short communication instead of full paper. Reply: Thanks to the Reviewer for his/her highly positive comments. As mentioned, we are limited by the constraints of a short communication that we indeed chose considering this work as a pilot study with the inclusion of only fifteen subjects. At the discretion of the Editor, the paper could possibly be considered for an Editorial to ...

International audience ; Reviewers' comments: Reviewer #1: Comments to Editor The manuscript "Increase of precuneus metabolism correlates with reduction of PTSD symptoms after EMDR therapy in military veterans: an 18F-FDG PET study during virtual reality exposure to war" by Rousseau et al deals with very actual topic: the disclosure of the neurobiology of psychotherapies. Furthermore, approaching such matter by PET activation studies, after about 30 years since the first 15O-H2O ones, using FDG might start a new season for this fascinating research field The manuscript is concise, well written and pretty clear in the aims, methods, results and discussion and in my opinion misses only a few information that will would improve its quality. I have a general comment and some minor specific remarks General comments The authors have recently published on the EJNMMI an editorial promoting functional 18F-FDG PET brain activation imaging. A similar study to the present one was published on the same Journal in 2015 (Eur J Nucl Med Mol Imaging (2015) 42:733-740) in which the very same protocol and methodology were used with the only difference that the stressing stimulus was olfactory and not visual. Since the readers of the present paper will be (firstly) nuclear medicine physicians it is opinion of this reviewer that the above paper should be quoted and the methodology implemented in both of them better "promoted" in the introduction and discussion to stimulate the colleagues to perform similar studies. It is also the opinion of this reviewer that it is a pity that the authors decided to submit such interesting and groundbreaking paper as short communication instead of full paper. Reply: Thanks to the Reviewer for his/her highly positive comments. As mentioned, we are limited by the constraints of a short communication that we indeed chose considering this work as a pilot study with the inclusion of only fifteen subjects. At the discretion of the Editor, the paper could possibly be considered for an Editorial to ...

International audience ; Reviewers' comments: Reviewer #1: Comments to Editor The manuscript "Increase of precuneus metabolism correlates with reduction of PTSD symptoms after EMDR therapy in military veterans: an 18F-FDG PET study during virtual reality exposure to war" by Rousseau et al deals with very actual topic: the disclosure of the neurobiology of psychotherapies. Furthermore, approaching such matter by PET activation studies, after about 30 years since the first 15O-H2O ones, using FDG might start a new season for this fascinating research field The manuscript is concise, well written and pretty clear in the aims, methods, results and discussion and in my opinion misses only a few information that will would improve its quality. I have a general comment and some minor specific remarks General comments The authors have recently published on the EJNMMI an editorial promoting functional 18F-FDG PET brain activation imaging. A similar study to the present one was published on the same Journal in 2015 (Eur J Nucl Med Mol Imaging (2015) 42:733-740) in which the very same protocol and methodology were used with the only difference that the stressing stimulus was olfactory and not visual. Since the readers of the present paper will be (firstly) nuclear medicine physicians it is opinion of this reviewer that the above paper should be quoted and the methodology implemented in both of them better "promoted" in the introduction and discussion to stimulate the colleagues to perform similar studies. It is also the opinion of this reviewer that it is a pity that the authors decided to submit such interesting and groundbreaking paper as short communication instead of full paper. Reply: Thanks to the Reviewer for his/her highly positive comments. As mentioned, we are limited by the constraints of a short communication that we indeed chose considering this work as a pilot study with the inclusion of only fifteen subjects. At the discretion of the Editor, the paper could possibly be considered for an Editorial to ...

International audience ; Background: We recently reported an improvement of precuneus PET metabolism after EMDR therapy in military participants suffering from PTSD. Objective: The aim of the present study was to investigate the metabolic changes of precuneus connectivity in these participants after such treatment. Method: Fifteen participants with PTSD performed a brain 18F-FDG-PET sensitized by virtual reality exposure to war scenes, before and after EMDR treatment. Interregional correlation analysis was performed to study metabolic changes of precuneus connectivity through SPMT maps at whole-brain level (p < 0.005 for the voxel, p < 0.05 for the cluster). Results: A decrease of connectivity was observed after EMDR between the precuneus and two significant bilateral clusters of the cerebellum (bilateral Crus I and VI cerebellar lobules, Tmax voxel of 5.8 and 5.3, and cluster size of 343 and 314 voxels, respectively). Moreover, higher cerebellar metabolism before treatment was associated with reduced clinical PTSD scores after EMDR (p = 0.03). Conclusions: The posterior cerebellum and its metabolic connectivity with the precuneus are involved in the clinical efficiency of EMDR in PTSD.

International audience ; BackgroundWe recently reported an improvement of precuneus PET metabolism after EMDR therapy in military participants suffering from PTSD.ObjectiveThe aim of the present study was to investigate the metabolic changes of precuneus connectivity in these participants after such treatment.MethodFifteen participants with PTSD performed a brain 18F-FDG-PET sensitized by virtual reality exposure to war scenes, before and after EMDR treatment. Inter-regional correlation analysis was performed to study metabolic changes of precuneus connectivity through SPMT maps at whole-brain level (p < 0.005 for the voxel, p < 0.05 for the cluster).ResultsA decrease of connectivity was observed after EMDR between the precuneus and two significant bilateral clusters of the cerebellum (bilateral Crus I and VI cerebellar lobules, Tmax voxel of 5.8 and 5.3, and cluster size of 343 and 314 voxels, respectively). Moreover, higher cerebellar metabolism before treatment was associated with reduced clinical PTSD scores after EMDR (p = 0.03).ConclusionsThe posterior cerebellum and its metabolic connectivity with the precuneus are involved in the clinical efficiency of EMDR in PTSD.

International audience ; BackgroundWe recently reported an improvement of precuneus PET metabolism after EMDR therapy in military participants suffering from PTSD.ObjectiveThe aim of the present study was to investigate the metabolic changes of precuneus connectivity in these participants after such treatment.MethodFifteen participants with PTSD performed a brain 18F-FDG-PET sensitized by virtual reality exposure to war scenes, before and after EMDR treatment. Inter-regional correlation analysis was performed to study metabolic changes of precuneus connectivity through SPMT maps at whole-brain level (p < 0.005 for the voxel, p < 0.05 for the cluster).ResultsA decrease of connectivity was observed after EMDR between the precuneus and two significant bilateral clusters of the cerebellum (bilateral Crus I and VI cerebellar lobules, Tmax voxel of 5.8 and 5.3, and cluster size of 343 and 314 voxels, respectively). Moreover, higher cerebellar metabolism before treatment was associated with reduced clinical PTSD scores after EMDR (p = 0.03).ConclusionsThe posterior cerebellum and its metabolic connectivity with the precuneus are involved in the clinical efficiency of EMDR in PTSD.

International audience ; BackgroundWe recently reported an improvement of precuneus PET metabolism after EMDR therapy in military participants suffering from PTSD.ObjectiveThe aim of the present study was to investigate the metabolic changes of precuneus connectivity in these participants after such treatment.MethodFifteen participants with PTSD performed a brain 18F-FDG-PET sensitized by virtual reality exposure to war scenes, before and after EMDR treatment. Inter-regional correlation analysis was performed to study metabolic changes of precuneus connectivity through SPMT maps at whole-brain level (p < 0.005 for the voxel, p < 0.05 for the cluster).ResultsA decrease of connectivity was observed after EMDR between the precuneus and two significant bilateral clusters of the cerebellum (bilateral Crus I and VI cerebellar lobules, Tmax voxel of 5.8 and 5.3, and cluster size of 343 and 314 voxels, respectively). Moreover, higher cerebellar metabolism before treatment was associated with reduced clinical PTSD scores after EMDR (p = 0.03).ConclusionsThe posterior cerebellum and its metabolic connectivity with the precuneus are involved in the clinical efficiency of EMDR in PTSD.

International audience ; Background: We recently reported an improvement of precuneus PET metabolism after EMDR therapy in military participants suffering from PTSD. Objective: The aim of the present study was to investigate the metabolic changes of precuneus connectivity in these participants after such treatment. Method: Fifteen participants with PTSD performed a brain 18F-FDG-PET sensitized by virtual reality exposure to war scenes, before and after EMDR treatment. Interregional correlation analysis was performed to study metabolic changes of precuneus connectivity through SPMT maps at whole-brain level (p < 0.005 for the voxel, p < 0.05 for the cluster). Results: A decrease of connectivity was observed after EMDR between the precuneus and two significant bilateral clusters of the cerebellum (bilateral Crus I and VI cerebellar lobules, Tmax voxel of 5.8 and 5.3, and cluster size of 343 and 314 voxels, respectively). Moreover, higher cerebellar metabolism before treatment was associated with reduced clinical PTSD scores after EMDR (p = 0.03). Conclusions: The posterior cerebellum and its metabolic connectivity with the precuneus are involved in the clinical efficiency of EMDR in PTSD.

International audience ; BackgroundWe recently reported an improvement of precuneus PET metabolism after EMDR therapy in military participants suffering from PTSD.ObjectiveThe aim of the present study was to investigate the metabolic changes of precuneus connectivity in these participants after such treatment.MethodFifteen participants with PTSD performed a brain 18F-FDG-PET sensitized by virtual reality exposure to war scenes, before and after EMDR treatment. Inter-regional correlation analysis was performed to study metabolic changes of precuneus connectivity through SPMT maps at whole-brain level (p < 0.005 for the voxel, p < 0.05 for the cluster).ResultsA decrease of connectivity was observed after EMDR between the precuneus and two significant bilateral clusters of the cerebellum (bilateral Crus I and VI cerebellar lobules, Tmax voxel of 5.8 and 5.3, and cluster size of 343 and 314 voxels, respectively). Moreover, higher cerebellar metabolism before treatment was associated with reduced clinical PTSD scores after EMDR (p = 0.03).ConclusionsThe posterior cerebellum and its metabolic connectivity with the precuneus are involved in the clinical efficiency of EMDR in PTSD.

International audience ; Background: We recently reported an improvement of precuneus PET metabolism after EMDR therapy in military participants suffering from PTSD. Objective: The aim of the present study was to investigate the metabolic changes of precuneus connectivity in these participants after such treatment. Method: Fifteen participants with PTSD performed a brain 18F-FDG-PET sensitized by virtual reality exposure to war scenes, before and after EMDR treatment. Interregional correlation analysis was performed to study metabolic changes of precuneus connectivity through SPMT maps at whole-brain level (p < 0.005 for the voxel, p < 0.05 for the cluster). Results: A decrease of connectivity was observed after EMDR between the precuneus and two significant bilateral clusters of the cerebellum (bilateral Crus I and VI cerebellar lobules, Tmax voxel of 5.8 and 5.3, and cluster size of 343 and 314 voxels, respectively). Moreover, higher cerebellar metabolism before treatment was associated with reduced clinical PTSD scores after EMDR (p = 0.03). Conclusions: The posterior cerebellum and its metabolic connectivity with the precuneus are involved in the clinical efficiency of EMDR in PTSD.

International audience ; Abstract Eye movement desensitization and reprocessing (EMDR) is a psychotherapy for the treatment of posttraumatic stress disorder (PTSD). It is still unclear whether symptoms remission through EMDR therapy is associated with a beneficial effect on one of the PTSD symptoms, sleep disturbance. Our objective was therefore to study sleep parameters before and after symptom remission in soldiers with PTSD. The control group consisted of 20 healthy active duty military men who slept in a sleep lab with standard polysomnography (PSG) on two sessions separated by one month. The patient group consisted of 17 active duty military with PTSD who underwent EMDR therapy. PSG-recorded sleep was assessed 1 week before the EMDR therapy began and 1 week after PTSD remission. We found that the increased REMs density after remission was positively correlated with a greater decrease of symptoms. Also, the number of EMDR sessions required to reach remission was correlated with intra-sleep awakenings before treatment. These results confirm the improvement of some sleep parameters in PTSD after symptoms remission in a soldier's population and provide a possible predictor of treatment success. Further experiments will be required to establish whether this effect is specific to the EMDR therapy.