Suchergebnisse

Entre las diversas respuestas colectivas que emergen en el marco de la crisis por la que atraviesa Argentina en el año 2001 está la de los trabajadores que recuperan la vida productiva de empresas en situación de abandono, quiebra o cierre. Sin tener su origen en la crisis, la recuperación de empresas adquiere en dicho contexto rasgos particulares como respuesta colectiva de resistencia defensiva ante la pérdida del empleo. El objetivo que persigo en este artículo es abordar la significación política que tiene dicha respuesta y el modelo autogestión colectiva de los trabajadores en su propia subjetividad narrativa a través de los discursos recogidos en Chilavert, una empresa gráfica de Buenos Aires recuperada en el año 2002. ; Amid a backdrop of deep economic crisis like the one that lives Argentina in 2001 produced the highest number of recoveries from the companies in the country. It is a collective response of defensive resistance starring workers to keep their jobs in a situation of extreme necessity, marked by the closure of the company and the difficulties in finding a job in this situation in which they reach unemployment and poverty figures hitherto unknown. The aim of this article is to address the political significance that has the recovery narrative subjectivity that workers have staged through the speeches collected between Chilavert workers, a business chart of Buenos Aires recovered in 2002.

Incidents of companies being recovered by their workers that have occurred in different countries have attracted media attention. Based on ideological tendencies, some experts have interpreted these processes as an indicator for their fulfilment of their own predictions.In contrast to these interpretations, this article focuses on the effectiveness of the use of the main premises of Participatory Action Research (PAR). The focus is on understanding the point of view of the involved protagonists. Qualitative evidence is presented (Dz Ru, 2014) demonstrating the existence of disaffected feelings towards experts caused by their inverviewing approaches. This disaffection is explained as a consequence of pre-built ideas connected to the experts' ideological tendencies.

El diagnóstico que vienen haciendo las ciencias sociales, y en particular la sociología urbana, sobre la situación actual de las sociedades desarrolladas, se vertebra a partir del proceso de individualización concebido fundamentalmente como una pérdida progresiva de contenidos y significados sociales compartidos. Así la postmodernidad (destracionalizante) es la máxima condición de posibilidad de la ciudad y de lo urbano en la difuminación que experimenta su dimensión colectiva. La ciudad, entonces, queda resumida a partir de la racionalización progresiva que arrasa los lugares como topos de uso público y escinde la convivencia ciudadana en tantas trayectorias biográficas como individuos la habitan, mediando entre ellos vínculos que apenas trascienden la dimensión grupal en la que estos se localizan. Si bien las ciudades han sido históricamente el espacio social en el que se han hecho explícitos todos los conflictos de poder y dominación que han resultado de la instauración de la modernidad; si bien pueden describirse como espacios de dura supervivencia en los cuales la desigualdad social acrecienta las fronteras internas entre modos distintos de vida, se hace evidente al tiempo que ciudad y ser humano guardan entre sí una relación de íntima inherencia que las convierte a aquellas en espacios articulados a partir de un sentido social eminentemente convivencial. A partir de esta premisa metodológica, la ciudad y lo que en ella acontece, es el resultado de una práctica social de convivencia que las generaciones que se suceden y los distintos grupos sociales que se enfrentan van estableciendo a partir de la reciprocidad que guardan. Se propone, por tanto, una lectura de la ciudad como sistema social urbano que aborde tanto la solidaridad como el antagonismo, la semejanza como la diferencia. Para ello se hará uso de una serie de conceptos que permiten reconstruir la vida en las ciudades a partir de la complementariedad entre la socialidad de la condición humana y el carácter agencial de su acción. Entre dichos conceptos se encuentran la ética de responsabilidad individual de M.Weber y el diacrítico cultural que propone M. Fernández-Martorell, además de las aportaciones sobre la ciudad que nos brindaron autores como F. Tonnïes, G. Simmel, L. Wirth y H. Lefebvre. Su lectura permite acceder a una comprensión de la vida en las grandes urbes, emblemas por excelencia de modernidad, como el resultado de una organización social distinta y particular a anteriores formaciones de asentamiento colectivo que,no obstante, siguen evidenciando la continuidad histórica de la ciudad como espacio urbano de convivencia social.

Actualmente, las plataformas e-learning, plataformas educativas o entornos virtuales de enseñanza-aprendizaje, forman parte de la realidad tecnológica que se ha creado en internet y que actúa como herramienta de aprendizaje en el ámbito educativo actual. Por ello, el uso de estas plataformas tiene una gran importancia hoy día, dado que permiten crear y desarrollar cursos completos en la web sin necesidad de poseer conocimientos profundos de informática. (Lojano, 2009). No obstante, existe cierta confusión en la definición y aplicaciones actuales de estas plataformas también conocidas como Virtual Learning Environment (Alzaga, 2011). El presente estudio parte del diseño de instrumentos para la evaluación de indicadores relevantes de las plataformas virtuales de enseñanza y aprendizaje desde una perspectiva multidisciplinar en entornos b-learning. La metodología empleada es, en un primer momento, descriptiva, en la que se identifican las variables específicas del e-learning en cada plataforma, así como el uso que los docentes y el alumnado hacen de esa plataforma. En un segundo momento se emplea una metodología correlacional en la que se busca encontrar la relación entre el uso y el diseño de dicha plataforma. Se han empleado instrumentos como el cuestionario y el análisis de contenido para la elaboración de indicadores de calidad.

35 pages, 8 figures, 3 tables.-- Pre-print archive. ; A method for the asteroseismic analysis of beta Cephei stars is presented and applied to the star nu Eridani. The method is based on the analysis of rotational splittings, and their asymmetries using differentially-rotating asteroseismic models. Models with masses around 7.13 M_sun, and ages around 14.9 Myr, were found to fit better 10 of the 14 observed frequencies, which were identified as the fundamental radial mode and the three L=1 triplets g, p, and p. The splittings and aymmetries found for these modes recover those provided in the literature, except for p. For this last mode, all its non-axysimmetric components are predicted by the models. Moreover, opposite signs of the observed and predicted splitting asymmetries are found. If identification is confirmed, this can be a very interesting source of information about the internal rotation profile, in particular in the outer regions of the star. In general, the seismic models which include a description for shellular rotation yield slightly better results as compared with those given by uniformly-rotating models. Furthermore, we show that asymmetries are quite dependent on the overshooting of the convective core, which make the present technique suitable for testing the theories describing the angular momentum redistribution and chemical mixing due to rotationally-induced turbulence. ; JCS acknowledges support by the "Instituto de Astrofísica de Andalucía" by an I3P contract financed by the European Social Fund and from the Spanish "Plan Nacional del Espacio" under project ESP2007-65480-C02-01. PJA acknowledges financial support from a "Ramon y Cajal" contract of the Spanish Ministry of Education and Science. CRL acknowledges financial support from an "´ Angeles Alvariño" contract of the "Xunta de Galicia", local government. ; Peer reviewed

An increased risk of developing colorectal cancer (CRC) and other types of tumor is associated to Lynch syndrome (LS), an inherited condition caused by germline mutations in mismatch repair genes. We selected a cohort of LS patients that had developed CRC and had undergone surgical resection. Formalin-fixed paraffin embedded (FFPE) tissue blocks from matched colorectal and normal mucosa were used for genomic DNA extraction with a commercial kit and sequenced by high-throughput sequencing. A metagenomic approach enabled the taxonomic and functional identification of the microbial community and associated genes detected in the specimens. Slightly lower taxonomic diversity was observed in the tumor compared to the non-tumor tissue. Furthermore, the most remarkable differences between tumors and healthy tissue was the significant increase in the genus Fusobacterium in the former, in particular the species F. nucleatum, as well as Camplylobacter or Bacteroides fragilis, in accordance with previous studies of CRC. However, unlike prior studies, the present work is not based on directed detection by qPCR but instead uses a metagenomic approach to retrieve the whole bacterial community, and addresses the additional difficulty of using long-term stored FFPE samples. ; We want to particularly acknowledge the patients and the Biobank IBSP-CV (PT17/0015/0017) integrated in the Spanish National Biobanks Network and in the Valencian Biobanking Network, especially A. Ahicart, D. Molina and J. Martínez, for their collaboration. This research was funded by grants to AM from the Fundación Científica de la Asociación Española contra el Cancer (project AECC 2017-1485), including a post-doctoral contract to VPB first and to SRR later. GD is recipient of a PhD fellowship from the Junta Asociada Provincial de Valencia AECC. Action co-financed by the European Union through the Operational Program of European Regional Development Fund (ERDF) of Valencia Region (Spain) 2014-2020. ; Peer reviewed

An increased risk of developing colorectal cancer (CRC) and other types of tumor is associated to Lynch syndrome (LS), an inherited condition caused by germline mutations in mismatch repair genes. We selected a cohort of LS patients that had developed CRC and had undergone surgical resection. Formalin-fixed paraffin embedded (FFPE) tissue blocks from matched colorectal and normal mucosa were used for genomic DNA extraction with a commercial kit and sequenced by high-throughput sequencing. A metagenomic approach enabled the taxonomic and functional identification of the microbial community and associated genes detected in the specimens. Slightly lower taxonomic diversity was observed in the tumor compared to the non-tumor tissue. Furthermore, the most remarkable differences between tumors and healthy tissue was the significant increase in the genus Fusobacterium in the former, in particular the species F. nucleatum, as well as Camplylobacter or Bacteroides fragilis, in accordance with previous studies of CRC. However, unlike prior studies, the present work is not based on directed detection by qPCR but instead uses a metagenomic approach to retrieve the whole bacterial community, and addresses the additional difficulty of using long-term stored FFPE samples. ; This research was funded by grants to AM from the Fundación Científica de la Asociación Española contra el Cancer (project AECC 2017-1485), including a post-doctoral contract to VPB first and to SRR later. GD is recipient of a PhD fellowship from the Junta Asociada Provincial de Valencia AECC. Action co-financed by the European Union through the Operational Program of European Regional Development Fund (ERDF) of Valencia Region (Spain) 2014-2020.

Thanks to high-precision photometric data legacy from space telescopes like CoRoT andKepler, the scientific community could detect and characterize the power spectra of hundreds of thousands of stars. Using the scaling relations, it is possible to estimate masses and radii for solar-type pulsators. However, these stars are not the only kind of stellar objects that follow these rules:delta Scuti stars seem to be characterized with seismic indexes such as the large separation (Delta nu). Thanks to long-duration high-cadence TESS light curves, we analysed more than two thousand of this kind of classical pulsators. In that way, we propose the frequency at maximum power (nu(max)) as a proper seismic index since it is directly related with the intrinsic temperature, mass and radius of the star. This parameter seems not to be affected by rotation, inclination, extinction or resonances, with the exception of the evolution of the stellar parameters. Furthermore, we can constrain rotation and inclination using the departure of temperature produced by the gravity-darkening effect. This is especially feasible for fast rotators as most of delta Scuti stars seem to be. © ESO 2020. ; We also thank the CoRoT, Kepler, and TESS teams whose efforts made these results possible. The CoRoT space mission was developed and operated by CNES, with contributions from Austria, Belgium, Brazil, ESA (RSSD and Science Program), Germany and Spain. Funding for Kepler's Discovery mission is provided by NASA's Science Mission Directorate. Funding for the TESS mission is provided by the NASA Explorer Program. The authors acknowledge the effort made by TASOC WG4 that helped us in our target selection. This publication makes use of VOSA, developed under the Spanish Virtual Observatory project supported by the Spanish MICIU through Grant AyA2017-84089. VOSA has been partially updated by using funding from the European Union's Horizon 2020 Research and Innovation Programme, under Grant Agreement No. 776403 (EXOPLANETS-A). SBF and DB received financial support from the Spanish State Research Agency (AEI) Projects No. ESP2017-87676-C5-1-R and No. MDM-2017-0737 Unidad de Excelencia "Maria de Maeztu"- Centro de Astrobiologia (INTA-CSIC). AM acknowledges funding from the European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie Grant agreement No. 749962 (project THOT). SMR acknowledges financial support from the State Agency for Research of the Spanish MICIU through the "Center of Excellence Severo Ochoa" award to the Instituto de Astrofisica de Andalucia (SEV-2017-0709). JCS and AGH acknowledge funding support from Spanish public funds (including FEDER fonds) for research under project ESP2017-87676-C5-2-R and ESP2017-87676-C5-5-R. JCS also acknowledges support from project RYC-2012-09913 under the "Ramon y Cajal" program of the Spanish Ministry of Science and Education. AGH acknowledges support from "Universidad de Granada" under project E-FQM-041-UGR18 from "Programa Operativo FEDER 2014-2020" programme by "Junta de Andalucia" regional Government. ; Peer reviewed

Theoretical calculations and some indirect observations show that massive exoplanets on tight orbits must decay due to tidal dissipation within their host stars. This orbital evolution could be observationally accessible through precise transit timing over a course of decades. The rate of planetary in-spiraling may not only help us to understand some aspects of evolution of planetary systems, but also can be used as a probe of the stellar internal structure. In this paper we present results of transit timing campaigns organized for a carefully selected sample of the Northern hemisphere hot Jupiter-like planets which were found to be the best candidates for detecting planet-star tidal interactions. Among them, there is the WASP-12 system which is the best candidate for possessing an in-falling giant exoplanet. Our new observations support the scenario of orbital decay of WASP-12 b and allow us to refine its rate. The derived tidal quality parameter of the host star Q¿ ¿ = (1.82 ± 0.32) × 105 is in agreement with theoretical predictions for subgiant stars. For the remaining systems - HAT-P-23, KELT-1, KELT-16, WASP-33, and WASP-103 - our transit timing data reveal no deviations from the constant-period models, hence constraints on the individual rates of orbital decay were placed. The tidal quality parameters of host stars in at least four systems - HAT-P-23, KELT-1, WASP-33, and WASP-103 - were found to be greater than the value reported for WASP-12. This is in line with the finding that those hosts are main sequence stars, for which efficiency of tidal dissipation is predicted to be relatively weak. © 2018 Copernicus Foundation for Polish Astronomy. All rights reserved.© 2018 Copernicus Foundation for Polish Astronomy. All rights reserved. ; We thank the referee for valuable comments which improved the paper. We also thank Dr. Laetitia Delrez and Dr. Pedro Sada for sharing the WASP-103 and HAT-P-23 light curves with us. GM and MS acknowledge the financial support from the National Science Centre, Poland through grant no. 2016/23/B/ST9/00579. MF acknowledges financial support from grants AYA2014-54348-C3-1-R and AYA2016-79425-C3-3-P of the Spanish Ministry of Economy and Competitiveness (MINECO), co-funded with EU FEDER funds. DD acknowledges the financial support of projects DN 08-1/2016, and DN 08-20/2016 of National Science Foundation of Bulgarian Ministry of education and science as well as by project RD 08-142 of Shumen University. CvE acknowledges funding for the Stellar Astrophysics Centre, which is provided by The Danish National Research Foundation (Grant agreement no.: DNRF106). DM acknowledges support from the National Science Centre (NCN) grant no. 2016/21/B/ST9/01126. A part of this paper is the result of the exchange and joint research project >Spectral and photometric studies of variable stars> between the Polish and Bulgarian Academies of Sciences. This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 730890. This material reflects only the authors views and the Commission is not liable for any use that may be made of the information contained therein. This research is based on (1) data obtained at the 1.5m telescope of the Sierra Nevada Observatory (Spain), which is operated by the Consejo Superior de Investigaciones Cientificas (CSIC) through the Instituto de Astrofisica de Andalucia, (2) data collected with telescopes at the Rozhen National Astronomical Observatory, (3) observations made with the Liverpool Telescope operated on the island of La Palma by Liverpool John Moores University in the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofisica de Canarias with financial support from the UK Science and Technology Facilities Council, (4) observationsmade with the Gran Telescopio Canarias (GTC), installed in the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofisica de Canarias, in the island of La Palma, and (5) observations obtained with telescopes of the University Observatory Jena, which is operated by the Astrophysical Institute of the Friedrich-Schiller-University.

© 2015 The Authors. Since 2006, the European Near Earth Asteroids Research (EURONEAR) project has been contributing to the research of near-Earth asteroids (NEAs) within a European network. One of the main aims is the amelioration of the orbits of NEAs, and starting in 2014 February we focus on the recovery of one-opposition NEAs using the Isaac Newton Telescope (INT) in La Palma in override mode. Part of this NEA recovery project, since 2014 June EURONEAR serendipitously started to discover and secure the first NEAs from La Palma and using the INT, thanks to the teamwork including amateurs and students who promptly reduce the data, report discoveries and secure new objects recovered with the INT and few other telescopes from the EURONEAR network. Five NEAs were discovered with the INT, including 2014 LU14, 2014 NL52 (one very fast rotator), 2014 OL339 (the fourth known Earth quasi-satellite), 2014 SG143 (a quite large NEA), and 2014 VP. Another very fast moving NEA was discovered but was unfortunately lost due to lack of follow-up time. Additionally, another 14 NEA candidates were identified based on two models, all being rapidly followed-up using the INT and another 11 telescopes within the EURONEAR network. They include one object discovered by Pan-STARRS, two Mars crossers, two Hungarias, one Jupiter trojan, and other few inner main belt asteroids (MBAs). Using the INT and Sierra Nevada 1.5 m for photometry, then the Gran Telescopio de Canarias for spectroscopy, we derived the very rapid rotation of 2014 NL52, then its albedo, magnitude, size, and its spectral class. Based on the total sky coverage in dark conditions, we evaluate the actual survey discovery rate using 2-m class telescopes. One NEA is possible to be discovered randomly within minimum 2.8 deg 2 and maximum 5.5 deg 2 . These findings update our past statistics, being based on double sky coverage and taking into account the recent increase in discovery. ; KK acknowledges support from the Polish Narodowe Centrum Nauki Grant UMO-2011/01/D/ST9/00427. LVM has been also supported by Grant AYA2011-30491-C02-01, co-financed by MICINN and FEDER funds, and the Junta de Andalucia (Spain) Grant TIC-114. SG was supported by the Slovak Grant Agency for Science VEGA, grant no. 1/0225/14. The research leading to these results has received funding from the European Research Council under the European Union's Seventh Framework Programme (FP/2007-2013)/ERC Grant Agreement no. 320964 (WDTracer). ; Peer Reviewed

Large variability among Alzheimer's disease (AD) cases might impact genetic discoveries and complicate dissection of underlying biological pathways. Genome Research at Fundacio ACE (GR@ACE) is a genome-wide study of dementia and its clinical endophenotypes, defined based on AD's clinical certainty and vascular burden. We assessed the impact of known AD loci across endophenotypes to generate loci categories. We incorporated gene coexpression data and conducted pathway analysis per category. Finally, to evaluate the effect of heterogeneity in genetic studies, GR@ACE series were meta-analyzed with additional genome-wide association study data sets. We classified known AD loci into three categories, which might reflect the disease clinical heterogeneity. Vascular processes were only detected as a causal mechanism in probable AD. The meta-analysis strategy revealed the ANKRD31-rs4704171 and NDUFAF6-rs10098778 and confirmed SCIMP-rs7225151 and CD33-rs3865444. The regulation of vasculature is a prominent causal component of probable AD. GR@ACE meta-analysis revealed novel AD genetic signals, strongly driven by the presence of clinical heterogeneity in the AD series. ; The authors would like to thank patients and controls who participated in this project. The Genome Research @ Fundació ACE project (GR@ACE) is supported by Fundación bancaria "La Caixa", Grifols SA, Fundació ACE, and ISCIII (Ministry of Health, Spain). They also want to thank the private sponsors who support the basic and clinical projects of our institution (Piramal AG, Laboratorios Echevarne, Araclon Biotech S.A., and Fundació ACE). They are indebted to the Trinitat Port‐Carbó legacy and her family for their support of Fundació ACE research programs. Fundació ACE is a participating center in the Dementia Genetics Spanish Consortium (DEGESCO). A.R. and M.B. receive support from the European Union/EFPIA Innovative Medicines Initiative Joint undertaking ADAPTED and MOPEAD projects (grant numbers 115975 and 115985, respectively). M.B. and A.R. are also supported by national grants PI13/02434, PI16/01861, and PI17/01474. Acción Estratégica en Salud is integrated into the Spanish National R + D + I Plan and funded by ISCIII (Instituto de Salud Carlos III)‐Subdirección General de Evaluación and the Fondo Europeo de Desarrollo Regional (FEDER‐ "Una manera de Hacer Europa"). L.M.R. is supported by Consejería de Salud de la Junta de Andalucía (grant PI‐0001/2017). Control samples and data from patients included in this study were provided in part by the National DNA Bank Carlos III (www.bancoadn.org, University of Salamanca, Spain) and Hospital Universitario Virgen de Valme (Sevilla, Spain); they were processed after standard operating procedures with the appropriate approval of the Ethical and Scientific Committee. The present work was performed as part of the Biochemistry, Molecular Biology, and Biomedicine doctoral program of S. Moreno‐Grau at Universitat Autònoma de Barcelona (Barcelona, Spain). Data collection and sharing for this project was partially funded by the Alzheimer's Disease Neuroimaging Initiative (ADNI) (National Institutes of Health grant U01 AG024904) and DOD ADNI (Department of Defense award number W81XWH‐12–2–0012). The ADNI is funded by the National Institute on Aging and the National Institute of Biomedical Imaging and Bioengineering, as well as through generous contributions from the following: AbbVie; the Alzheimer's Association; the Alzheimer's Drug Discovery Foundation; Araclon Biotech; BioClinica, Inc.; Biogen; Bristol‐Myers Squibb Company; CereSpir, Inc.; Cogstate; Eisai Inc.; Elan Pharmaceuticals, Inc.; Eli Lilly and Company; EuroImmun; F. Hoffmann‐La Roche Ltd and its affiliated company Genentech, Inc.; Fujirebio; GE Healthcare; IXICO Ltd.; Janssen Alzheimer Immunotherapy Research & Development, LLC.; Johnson & Johnson Pharmaceutical Research & Development LLC.; Lumosity; Lundbeck; Merck & Co., Inc.; Meso Scale Diagnostics, LLC.; NeuroRx Research; Neurotrack Technologies; Novartis Pharmaceuticals Corporation; Pfizer Inc.; Piramal Imaging; Servier; Takeda Pharmaceutical Company; and Transition Therapeutics. The Canadian Institutes of Health Research provides funds to support ADNI clinical sites in Canada. Private sector contributions are facilitated by the Foundation for the National Institutes of Health (www.fnih.org). The grantee organization is the Northern California Institute for Research and Education, and the study was coordinated by the Alzheimer's Therapeutic Research Institute at the University of Southern California. ADNI data are disseminated by the Laboratory for NeuroImaging at the University of Southern California. The AddNeuroMed data are from a public‐private partnership supported by EFPIA companies and SMEs as part of InnoMed (Innovative Medicines in Europe), an integrated project funded by the European Union of the Sixth Framework program priority FP6–2004‐LIFESCIHEALTH‐5. Clinical leads responsible for data collection are Iwona Kłoszewska (Lodz), Simon Lovestone (London), Patrizia Mecocci (Perugia), Hilkka Soininen (Kuopio), Magda Tsolaki (Thessaloniki), and Bruno Vellas (Toulouse). Imaging leads are Andy Simmons (London), Lars‐Olad Wahlund (Stockholm), and Christian Spenger (Zurich). Bioinformatics leads are Richard Dobson (London) and Stephen Newhouse (London). Funding support for the Alzheimer's Disease Genetics Consortium (ADGC) was provided through the NIA Division of Neuroscience (U01‐AG032984). The genotypic and associated phenotypic data used in the study "Multi‐Site Collaborative Study for Genotype‐Phenotype Associations in Alzheimer's Disease (GenADA)" were provided by GlaxoSmithKline, R&D Limited. The data sets used for the analyses described in this manuscript were obtained from dbGaP at http://www.ncbi.nlm.nih.gov/gap through dbGaP accession number phs000219. The Mayo Clinic Alzheimer's Disease Genetic Studies, led by Dr. Nilüfer Ertekin‐Taner and Dr. Steven G. Younkin at the Mayo Clinic in Jacksonville, FL, used samples from the Mayo Clinic Study of Aging, the Mayo Clinic Alzheimer's Disease Research Center, and the Mayo Clinic Brain Bank. Data c ; Sí

Surveys have shown that super-Earth and Neptune-mass exoplanets are more frequent than gas giants around low-mass stars, as predicted by the core accretion theory of planet formation. We report the discovery of a giant planet around the very-low-mass star GJ 3512, as determined by optical and near-infrared radial-velocity observations. The planet has a minimum mass of 0.46 Jupiter masses, very high for such a small host star, and an eccentric 204-day orbit. Dynamical models show that the high eccentricity is most likely due to planet-planet interactions. We use simulations to demonstrate that the GJ 3512 planetary system challenges generally accepted formation theories, and that it puts constraints on the planet accretion and migration rates. Disk instabilities may be more efficient in forming planets than previously thought.Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science ; This research was supported by the following programs, grants, and fellowships: Spanish Ministry for Science, Innovation and Universities (MCIU) ESP2014-54062-R, ESP2014-54362P, AYA2015-69350-C3-2-P, BES-2015-074542, AYA2016-79425-C3-1/2/3-P, ESP2016-76076-R, ESP2016-80435-C2-1-R, ESP2016-80435-C2-2-R, ESP2017-87143-R, ESP2017-87676-C05-02-R, ESP-2017-87676-2-2, RYC-2012-09913 (>Ramon y Cajal> program), and FPU15/01476; Israel Science Foundation grant 848/16, CONICYT-FONDECYT/Chile Postdoctorado 3180405; Deutsches Zentrum fur Luft-un Raumfahrt (DLR) 50OW0204 and 50OO1501; Italian Minister of Instruction, University and Research (MIUR), FFABR 2017; University of Rome Tor Vergata, >Mission: Sustainability 2016> fund; European Research Council under the European Union Horizon 2020 research and innovation program 694513; Mexican national council for science and technology CONACYT, CVU 448248; the >Center of Excellence Severo Ochoa> award for the Instituto de Astrofisica de Andalucia (SEV-2017-0709); Generalitat de Catalunya/CERCA program; Fondo Europeo de Desarollo Regional (FEDER); German Science Foundation (DFG) Research Unit FOR2544 >Blue Planets around Red Stars> and Priority Programs SPP 1833, >Building a Habitable Earth> and SPP 1992, >Exploring the Diversity of Extrasolar Planets> NSF grants PHY17-48958 and PHY-1607761; Swiss National Science Foundation under grant BSGIO_155816 >PlaneltsInTime' and within the framework of the NCCR PlanetS; Queen Mary University of London Scholarship and STFC Consolidated Grant ST/P000592/1; Spanish MCIU FPI-SO predoctoral contract BES-2017-082610 and the Knut and Alice Wallenberg Foundation.