MINI-FORUM: CELEBRATING AGA'S 50TH YEAR - AGA's Annual Meeting Marks 50th Year
In: The public manager: the new bureaucrat, Band 30, Heft 3, S. 3-4
ISSN: 1061-7639
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In: The public manager: the new bureaucrat, Band 30, Heft 3, S. 3-4
ISSN: 1061-7639
In: The family coordinator, Band 19, Heft 4, S. 295
In: The family coordinator, Band 19, Heft 1, S. 76
In: The annals of the American Academy of Political and Social Science, Band 272, Heft 1, S. 156-162
ISSN: 1552-3349
In: The annals of the American Academy of Political and Social Science, S. 156-162
ISSN: 0002-7162
For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types.
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