Suchergebnisse

<b><i>Aim:</i></b> The aim of this study was to evaluate the role of the glutamate receptor subunit-7 <i>(GluR7, GRIK 3)</i> rs6691840 (Ser310Ala, T928G) in the pathogenesis of alcohol dependence (AD). <b><i>Methods:</i></b> DNA was provided from AD patients (n = 209) and healthy control subjects (n = 308) all of Polish descent. The history of alcoholism was obtained using the Polish version of the SSAGA (Semi-Structured Assessment for the Genetics of Alcoholism). We conducted case-control association study and transmission disequilibrium test (TDT). <i>GRIK3 </i>functional polymorphism was genotyped by the PCR-RFLP method. <b><i>Results:</i></b> Analyses revealed that polymorphism Ser310Ala of <i>GRIK3</i> gene is not associated with AD or any of its subgroups. TDT reveled an adequate transmission of both alleles in the group of alcohol families. <b><i>Conclusions:</i></b> These findings replicate and extend our previous research results that do not support the hypothesis of the role of rs6691840 in the pathogenesis of AD.