<b><i>Aim:</i></b> The aim of this study was to evaluate the role of the glutamate receptor subunit-7 <i>(GluR7, GRIK 3)</i> rs6691840 (Ser310Ala, T928G) in the pathogenesis of alcohol dependence (AD). <b><i>Methods:</i></b> DNA was provided from AD patients (n = 209) and healthy control subjects (n = 308) all of Polish descent. The history of alcoholism was obtained using the Polish version of the SSAGA (Semi-Structured Assessment for the Genetics of Alcoholism). We conducted case-control association study and transmission disequilibrium test (TDT). <i>GRIK3 </i>functional polymorphism was genotyped by the PCR-RFLP method. <b><i>Results:</i></b> Analyses revealed that polymorphism Ser310Ala of <i>GRIK3</i> gene is not associated with AD or any of its subgroups. TDT reveled an adequate transmission of both alleles in the group of alcohol families. <b><i>Conclusions:</i></b> These findings replicate and extend our previous research results that do not support the hypothesis of the role of rs6691840 in the pathogenesis of AD.
In: Alcohol and alcoholism: the international journal of the Medical Council on Alcoholism (MCA) and the journal of the European Society for Biomedical Research on Alcoholism (ESBRA), Band 42, Heft 2, S. 75-79
In: Alcohol and alcoholism: the international journal of the Medical Council on Alcoholism (MCA) and the journal of the European Society for Biomedical Research on Alcoholism (ESBRA), Band 48, Heft suppl 1, S. i10-i11
In: Alcohol and alcoholism: the international journal of the Medical Council on Alcoholism (MCA) and the journal of the European Society for Biomedical Research on Alcoholism (ESBRA), Band 48, Heft suppl 1, S. i32-i33
In: Alcohol and alcoholism: the international journal of the Medical Council on Alcoholism (MCA) and the journal of the European Society for Biomedical Research on Alcoholism (ESBRA), Band 46, Heft Supplement 1, S. i21-i22
Background. Compulsory admission procedures of patients with mental disorders vary between countries in Europe. The Ethics Committee of the European Psychiatric Association (EPA) launched a survey on involuntary admission procedures of patients with mental disorders in 40 countries to gather information from all National Psychiatric Associations that are members of the EPA to develop recommendations for improving involuntary admission processes and promote voluntary care. Methods. The survey focused on legislation of involuntary admissions and key actors involved in the admission procedure as well as most common reasons for involuntary admissions. Results. We analyzed the survey categorical data in themes, which highlight that both medical and legal actors are involved in involuntary admission procedures. Conclusions. We conclude that legal reasons for compulsory admission should be reworded in order to remove stigmatization of the patient, that raising awareness about involuntary admission procedures and patient rights with both patients and family advocacy groups is paramount, that communication about procedures should be widely available in lay-language for the general population, and that training sessions and guidance should be available for legal and medical practitioners. Finally, people working in the field need to be constantly aware about the ethical challenges surrounding compulsory admissions.
Background. Compulsory admission procedures of patients with mental disorders vary between countries in Europe. The Ethics Committee of the European Psychiatric Association (EPA) launched a survey on involuntary admission procedures of patients with mental disorders in 40 countries to gather information from all National Psychiatric Associations that are members of the EPA to develop recommendations for improving involuntary admission processes and promote voluntary care. Methods. The survey focused on legislation of involuntary admissions and key actors involved in the admission procedure as well as most common reasons for involuntary admissions. Results. We analyzed the survey categorical data in themes, which highlight that both medical and legal actors are involved in involuntary admission procedures. Conclusions. We conclude that legal reasons for compulsory admission should be reworded in order to remove stigmatization of the patient, that raising awareness about involuntary admission procedures and patient rights with both patients and family advocacy groups is paramount, that communication about procedures should be widely available in lay-language for the general population, and that training sessions and guidance should be available for legal and medical practitioners. Finally, people working in the field need to be constantly aware about the ethical challenges surrounding compulsory admissions. ; Peer reviewed
In: Wasserman , D , Apter , G , Baeken , C , Bailey , S , Balazs , J , Bec , C , Bienkowski , P , Bobes , J , Ortiz , M F B , Brunn , H , Bôke , Camilleri , N , Carpiniello , B , Chihai , J , Chkonia , E , Courtet , P , Cozman , D , David , M , Dom , G , Esanu , A , Falkai , P , Flannery , W , Gasparyan , K , Gerlinger , G , Gorwood , P , Gudmundsson , O , Hanon , C , Heinz , A , Dos Santos , M J H , Hedlund , A , Ismayilov , F , Ismayilov , N , Isometsä , E T , Izakova , L , Kleinberg , A , Kurimay , T , Reitan , S K , Lecic-Tosevski , D , Lehmets , A , Lindberg , N , Lundblad , K A , Lynch , G , Maddock , C , Malt , U F , Martin , L , Martynikhin , I , Maruta , N O , Matthys , F , Mazaliauskiene , R , Mihajlovic , G , Peles , A M , Miklavic , V , Mohr , P , Ferrandis , M M , Musalek , M , Neznanov , N , Ostorharics-Horvath , G , Pajević , I , Popova , A , Pregelj , P , Prinsen , E , Rados , C , Roig , A , Kuzman , M R , Samochowiec , J , Sartorius , N , Savenko , Y , Skugarevsky , O , Slodecki , E , Soghoyan , A , Stone , D S , Taylor-East , R , Terauds , E , Tsopelas , C , Tudose , C , Tyano , S , Vallon , P , Van der Gaag , R J , Varandas , P , Vavrusova , L , Voloshyn , P , Wancata , J , Wise , J , Zemishlany , Z , Öncü , F & Vahip , S 2020 , ' Compulsory admissions of patients with mental disorders : State of the art on ethical and legislative aspects in 40 European countries ' , European psychiatry : the journal of the Association of European Psychiatrists , vol. 63 , no. 1 , pp. e82 . https://doi.org/10.1192/j.eurpsy.2020.79
BACKGROUND.: Compulsory admission procedures of patients with mental disorders vary between countries in Europe. The Ethics Committee of the European Psychiatric Association (EPA) launched a survey on involuntary admission procedures of patients with mental disorders in 40 countries to gather information from all National Psychiatric Associations that are members of the EPA to develop recommendations for improving involuntary admission processes and promote voluntary care. METHODS.: The survey focused on legislation of involuntary admissions and key actors involved in the admission procedure as well as most common reasons for involuntary admissions. RESULTS.: We analyzed the survey categorical data in themes, which highlight that both medical and legal actors are involved in involuntary admission procedures. CONCLUSIONS.: We conclude that legal reasons for compulsory admission should be reworded in order to remove stigmatization of the patient, that raising awareness about involuntary admission procedures and patient rights with both patients and family advocacy groups is paramount, that communication about procedures should be widely available in lay-language for the general population, and that training sessions and guidance should be available for legal and medical practitioners. Finally, people working in the field need to be constantly aware about the ethical challenges surrounding compulsory admissions.