FORMATE DEHYDROGENASE: FROM NAD(P)H REGENERATION TO THE TARGET IN PATHOGENS BIOFILMS, A COMPONENT OF HIGHLY EFFICIENT HYBRID BIOCATALYSTS AND CO2 FIXATION FROM THE ATMOSPHERE
In: Vestnik Moskovskogo Universiteta Serija Chimija: Moscow University chemistry bulletin, Band 64, Heft №4, 2023, S. 289-311
NAD(P)+
-dependent formate dehydrogenase (EC 1.2.1.2, FDH) catalyzes
the simple from chemical and biological point of view reaction of formate ion
oxidation to carbon dioxide with corresponding reduction of NAD(P)+
to NAD(P)
H. Advances in the life sciences have shown that this reaction plays an extremely
important role in a wide variety of organisms. The areas and types of practical
applications of FDH are also permanently expanding. In this review we considered
the main stages in the development of understanding and knowledge about the role of
formate dehydrogenase in living systems. Achievements in creation of highly effi cient
catalysts based on FDH for classic biotechnology as well as for new areas are also
considered. The importance of appropriate choice of the initial FDH for the creation
of a biocatalyst with the required and prescribed properties with minimal costs is
shown. The prospects for the use of FDH for the fixation of CO2 are discussed.