Suchergebnisse

This report documents the research efforts of a task order under a research technical agreement between the California Department of Transportation (Caltrans) and the University of California, Berkeley (UC Berkeley). The focus of this research is to understand the scientific and technical aspects of the potential use of ammonia and other related carbon-free energy carriers for hydrogen fuel cell applications. Caltrans has a range of potential applications for fuel cell technology, including various field operations and for providing emergency backup power, power "demand response" flexibility, and power "peak shaving" for its facilities. Ammonia is also a potential onboard hydrogen storage medium for vehicles, but we do not explicitly investigate that here. The interest in hydrogen and fuel cell technologies at Caltrans and other California government agencies is being driven by a confluence of policy-related events the emergence of new and improved hydrogen and fuel cell technologies. The specific policy drivers for hydrogen and fuel cells include the California Hydrogen Highway Network Initiative (Executive Order S-07-04), a statewide greenhouse gas (GHG) emission reduction effort (AB 32 and the AB 1493 "Pavley Law"), and the State's Zero-Emission Vehicle (ZEV) mandate. Also important are various drivers related to the use of electrical power in the wake of California's failed electricity sector deregulation effort, and the continued pressures of meeting the demands of growth in California's electricity needs. This research effort consisted of three primary tasks: 1) An extensive scientific and technical literature review for the use of ammonia and related compounds as a fuel/energy carrier, especially for stationary hydrogen fuel cell applications; 2) An assessment of the current state of technical performance and economics of existing commercial and pre-commercial technologies for ammonia supply for fuel cell applications; and 3) A suggested demonstration plan for a physical demonstration of an ammonia/hydrogen/fuel cell system in the context of Caltrans operations.

The SEAD initiative aims to transform the global market by increasing the penetration of highly efficient equipment and appliances. SEAD is a government initiative whose activities and projects engage the private sector to realize the large global energy savings potential from improved appliance and equipment efficiency. SEAD seeks to enable high-level global action by informing the Clean Energy Ministerial dialogue as one of the initiatives in the Global Energy Efficiency Challenge. In keeping with its goal of achieving global energy savings through efficiency, SEAD was approved as a task within the International Partnership for Energy Efficiency Cooperation (IPEEC) in January 2010. SEAD partners work together in voluntary activities to: (1) ?raise the efficiency ceiling? by pulling super-efficient appliances and equipment into the market through cooperation on measures like incentives, procurement, awards, and research and development (R&D) investments; (2) ?raise the efficiency floor? by working together to bolster national or regional policies like minimum efficiency standards; and (3) ?strengthen the efficiency foundations? of programs by coordinating technical work to support these activities. Although not all SEAD partners may decide to participate in every SEAD activity, SEAD partners have agreed to engage actively in their particular areas of interest through commitment of financing, staff, consultant experts, and other resources. In addition, all SEAD partners are committed to share information, e.g., on implementation schedules for and the technical detail of minimum efficiency standards and other efficiency programs. Information collected and created through SEAD activities will be shared among all SEAD partners and, to the extent appropriate, with the global public. As of April 2011, the governments participating in SEAD are: Australia, Brazil, Canada, the European Commission, France, Germany, India, Japan, Korea, Mexico, Russia, South Africa, Sweden, the United Arab Emirates, the United Kingdom, and the United States. More information on SEAD is available from its website at http://www.superefficient.org/.

Cardiovascular disease (CVD) remains a leading cause of death both within the United States (US) as well as globally. In 2006 alone, over one-third of all deaths in the US were attributable to CVD. The high prevalence, mortality, morbidity, and socioeconomic impact of CVD has motivated a significant research effort; however, there remain significant knowledge gaps regarding disease onset and progression as well as pressing needs for improved therapeutic approaches. One critical area of research that has received limited attention is the role of biophysical cues on the modulation of endothelial cell behaviors; specifically, the impact of local compliance, or the stiffness, of the surrounding vascular endothelial extracellular matrix. In this study, the impact of substratum compliance on the modulation of cell behaviors of several human primary endothelial cell types, representing different anatomic sites and differentiation states in vivo, were investigated. Substrates used within our studies span the range of compliance that has been reported for the vascular endothelial basement membrane. Differences in substratum compliance had a profound impact on cell attachment, spreading, elongation, proliferation, and migration. In addition, each cell population responded differentially to changes in substratum compliance, documenting endothelial heterogeneity in the response to biophysical cues. These results demonstrate the importance of incorporating substratum compliance in the design of in vitro experiments as well as future prosthetic design. Alterations in vascular substratum compliance directly influence endothelial cell behavior and may participate in the onset and/or progression of CVDs.